WNK lysine deficient protein kinase 4
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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
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|PGx Test||Variants Assayed||Related Drugs?|
|Alternate Symbols: ||None|
|PharmGKB Accession Id:||PA134875400|
|Cytogenetic Location:||chr17 : q21.31 - q22|
|GP mRNA Boundary†:||chr17 : 40932649 - 40949084|
|GP Gene Boundary†:||chr17 : 40922649 - 40952084|
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
Diuretics Pathway, Pharmacodynamics
Diagrammatic representation of candidate genes involved in the pharmacodynamics of diuretics in a stylized kidney cell.
Links to non-PharmGKB pathways.
PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.
Publications related to WNK4: 3
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||WNK kinases and the kidney. Experimental cell research. 2012. Hoorn Ewout J, et al.|
||A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension. 2005. Golbang Amir P, et al.|
||The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. Hypertension research : official journal of the Japanese Society of Hypertension. 2004. Matayoshi Tetsutaro, et al.|