WNK lysine deficient protein kinase 4
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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.
A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).
|PGx Test||Variants Assayed||Related Drugs?|
|Alternate Symbols: ||None|
|PharmGKB Accession Id:||PA134875400|
|Cytogenetic Location:||chr17 : q21.31 - q22|
|GP mRNA Boundary†:||chr17 : 40932649 - 40949084|
|GP Gene Boundary†:||chr17 : 40922649 - 40952084|
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
Diuretics Pathway, Pharmacodynamics
Diagrammatic representation of candidate genes involved in the pharmacodynamics of diuretics in a stylized kidney cell.
Links to non-PharmGKB pathways.
PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.
Publications related to WNK4: 4
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||Calcineurin inhibitors and hypertension: a role for pharmacogenetics?. Pharmacogenomics. 2014. Moes Arthur D, et al.|
||WNK kinases and the kidney. Experimental cell research. 2012. Hoorn Ewout J, et al.|
||A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension. 2005. Golbang Amir P, et al.|
||The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. Hypertension research : official journal of the Japanese Society of Hypertension. 2004. Matayoshi Tetsutaro, et al.|