PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.
PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.
| Position ? | Drug ? | Relevance ? |
Strength of Evidence ? |
||
|---|---|---|---|---|---|
Download a summary of all Clinical Annotations available.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
A non-comprehensive list of genetic tests for specific variants, including descriptions of and links to individual tests; manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.
| PGx Test | Variants Assayed | Related Drugs? |
|---|---|---|
| SLCO1B1 | rs2306283, rs2306283, rs4149056, rs4149056, SLCO1B1*1B, SLCO1B1*5, SLCO1B1*15 |
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.
Links in the "Drugs" column lead to PharmGKB Drug Pages.
|
Variant?
(build 132) |
Alternate Names ? | Drugs ? | Alleles ? | Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|
| rs11045819 | SLCO1B1:*4, SLCO1B1:463C>A, c.463C>A, g.14089937C>A, g.50686C>A, p.Pro155Thr | C > A | Missense | Pro155Thr | ||
| rs11045879 | OATP1B1: intronic C/T, c.1865+4846T>C, g.103492T>C, g.14142743T>C | C/T | Not Available | |||
| rs2306283 | SLCO1B1*1B, c.388A>G, c.388G>A, g.14089862A>G, g.50611A>G, p.Asn130Asp, p.Asp130Asn | T > T/C | Missense | Asn130Asn/Asp | ||
| rs4149015 | SLCO1B1:11187G>A, SLCO1B1:G-11187A, g.14043446G>A, g.4195G>A | A/G | Not Available | |||
| rs4149056 | SLCO1B1*5, c.521T>C, g.14091673T>C, g.52422T>C, p.Val174Ala | T > C | Missense | Val174Ala | ||
| rs4149081 | OATP1B1: intronic A/G, c.1865+248G>A, g.14138145G>A, g.98894G>A | A/G | Not Available |
Overview
| Alternate Names: | OATP-2; liver-specific organic anion transporter 1; sodium-independent organic anion-transporting polypeptide 2; solute carrier family 21 (organic anion transporter), member 6; solute carrier family 21 member 6; solute carrier organic anion transporter family member 1B1 |
|---|---|
| Alternate Symbols: | LST-1; LST1; MGC133282; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6 |
| Haplotypes: | SLCO1B1*1A; SLCO1B1*1B; SLCO1B1*1C; SLCO1B1*2; SLCO1B1*3; SLCO1B1*4; SLCO1B1*5; SLCO1B1*6; SLCO1B1*7; SLCO1B1*8; SLCO1B1*9; SLCO1B1*10; SLCO1B1*11; SLCO1B1*12; SLCO1B1*13; SLCO1B1*14; SLCO1B1*15; SLCO1B1*16; SLCO1B1*17; SLCO1B1*22; SLCO1B1*23; SLCO1B1*24; SLCO1B1*25; SLCO1B1*26; SLCO1B1*27; SLCO1B1*28; SLCO1B1*29; SLCO1B1*30; SLCO1B1*31; SLCO1B1*32; SLCO1B1*33; SLCO1B1*34; SLCO1B1*35; SLCO1B1*36 |
| PharmGKB Accession Id: | PA134865839 |
Details
| Cytogenetic Location: | chr12 : p12.2 - p12.1 |
|---|---|
| GP mRNA Boundary†: | chr12 : 21284137 - 21392730 |
| GP Gene Boundary†: | chr12 : 21274137 - 21395730 |
| Strand: | plus |
| Product Name: | solute carrier family 21 (organic anion transporter), member 6, solute carrier organic anion transporter family, member 1B1 |
All alleles are displayed on the positive chromosomal strand.
| Haplotype | chr12:21325710 (hg19) | chr12:21355487 (hg19) | chr12:21392079 (hg19) | rs11045819 | rs11045852 | rs11045853 | rs139257324 | rs140790673 | rs142965323 | rs2306283 | rs34671512 | rs4149015 | rs4149056 | rs55737008 | rs55901008 | rs56061388 | rs56101265 | rs56199088 | rs56387224 | rs59113707 | rs59502379 | rs59710386 | rs72559745 | rs72559748 | rs79135870 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SLCO1B1*1A | G | T | C | C | A | G | C | C | G | A | A | G | T | A | T | T | T | A | A | C | G | A | A | A | A |
| SLCO1B1*1B | G | T | C | C | A | G | C | C | G | G | A | G | T | A | T | T | T | A | A | C | G | A | A | A | A |
| SLCO1B1*1C | G | T | C | C | A | G | C | C | G | A | A | G | T | A | T | T | T | A | A | C | G | A | A | A | A |
| SLCO1B1*2 | G | T | C | C | A | G | C | C | G | A | A | G | T | A | T | T | C | A | A | C | G | A | A | A | A |
| SLCO1B1*3 | G | T | C | C | A | G | C | C | G | A | A | G | T | A | T | C | T | A | A | C | G | A | G | A | A |
| SLCO1B1*4 | G | T | C | A | A | G | C | C | G | A | A | G | T | A | T | T | T | A | A | C | G | A | A | A | A |
| SLCO1B1*5 | G | T | C | C | A | G | C | C | G | A | A | G | C | A | T | T | T | A | A | C | G | A | A | A | A |
| SLCO1B1*6 | G | T | C | C | A | G | C | C | G | A | A | G | T | A | C | T | T | A | A | C | G | A | A | A | A |
| SLCO1B1*7 | G | T | C | C | A | G | C | C | G | A | A | G | T | A | T | T | T | A | G | C | G | A | A | A | A |
| SLCO1B1*8 | G | T | C | C | A | G | C | C | G | A | A | G | T | A | T | T | T | A | A | C | G | A | A | G | A |
| SLCO1B1*9 | G | T | C | C | A | G | C | C | G | A | A | G | T | A | T | T | T | A | A | C | C | A | A | A | A |
| SLCO1B1*10 | G | T | C | C | A | G | C | C | G | A | A | G | T | A | T | T | T | G | A | C | G | A | A | A | A |
| SLCO1B1*11 | G | T | C | C | A | G | C | C | G | A | A | G | T | G | T | T | T | A | A | C | G | A | A | A | A |
| SLCO1B1*12 | G | T | C | C | A | G | C | C | G | A | A | G | T | A | T | T | C | G | A | C | G | A | A | A | A |
| SLCO1B1*13 | G | T | C | C | A | G | C | C | G | A | A | G | T | G | T | C | T | A | A | C | G | A | G | A | A |
| SLCO1B1*14 | G | T | C | A | A | G | C | C | G | G | A | G | T | A | T | T | T | A | A | C | G | A | A | A | A |
| SLCO1B1*15 | G | T | C | C | A | G | C | C | G | G | A | G | C | A | T | T | T | A | A | C | G | A | A | A | A |
| SLCO1B1*16 | G | T | C | C | A | G | C | C | G | G | A | G | C | A | T | T | T | A | A | C | G | C | A | A | A |
| SLCO1B1*17 | G | T | C | C | A | G | C | C | G | G | A | A | C | A | T | T | T | A | A | C | G | A | A | A | A |
| SLCO1B1*22 | G | T | C | C | A | G | C | C | G | A | C | T | A | T | T | T | A | A | C | G | A | A | A | A | |
| SLCO1B1*23 | A | T | C | C | A | G | C | C | G | A | A | T | A | T | T | T | A | A | C | G | A | A | A | A | |
| SLCO1B1*24 | G | T | C | C | G | G | C | C | G | G | A | T | A | T | T | T | A | A | C | G | A | A | A | A | |
| SLCO1B1*25 | G | T | C | A | G | A | C | C | G | G | A | T | A | T | T | T | A | A | C | G | A | A | A | A | |
| SLCO1B1*26 | G | T | C | C | A | G | C | C | A | A | A | T | A | T | T | T | A | A | C | G | A | A | A | A | |
| SLCO1B1*27 | G | T | C | C | A | G | C | C | G | G | A | T | A | T | T | T | A | A | G | G | A | A | A | A | |
| SLCO1B1*28 | G | T | C | C | G | A | C | C | G | G | A | T | A | T | T | T | A | A | C | G | A | A | A | A | |
| SLCO1B1*29 | G | T | C | C | A | G | C | T | G | G | A | T | A | T | T | T | A | A | C | G | A | A | A | A | |
| SLCO1B1*30 | G | T | C | C | A | G | C | C | G | G | A | T | A | T | T | T | A | A | C | G | A | A | A | G | |
| SLCO1B1*31 | G | T | C | C | A | G | C | C | G | G | A | T | A | T | T | T | A | A | C | C | A | A | A | A | |
| SLCO1B1*32 | G | T | C | A | G | G | C | C | G | G | A | T | A | T | T | T | A | A | C | G | A | A | A | A | |
| SLCO1B1*33 | G | T | C | C | G | A | G | C | G | G | A | T | A | T | T | T | A | A | C | G | A | A | A | A | |
| SLCO1B1*34 | G | T | T | C | A | G | C | C | G | A | A | T | A | T | T | T | A | A | C | G | A | A | A | A | |
| SLCO1B1*35 | G | T | C | C | A | G | C | C | G | G | C | T | A | T | T | T | A | A | C | G | A | A | A | A | |
| SLCO1B1*36 | G | G | C | C | A | G | C | C | G | A | A | T | A | T | T | T | A | A | C | G | A | A | A | A |
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
-
Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics
Nateglinide metabolism and transport in liver cell.
-
Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics
Repaglinide metabolism and transport in a liver cell.
-
Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
Drug-specific representation of the candidate genes involved in transport, metabolism and clearance.
-
Codeine and Morphine Pathway, Pharmacokinetics
Representation of the candidate genes involved in metabolism of codeine and morphine.
-
Fluvastatin Pathway, Pharmacokinetics
Drug-specific representation of the candidate genes involved in transport, metabolism and clearance.
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Irinotecan Pathway, Pharmacokinetics
Model human liver cell showing blood, bile and intestinal compartments, indicating tissue specific involvement of genes in the irinotecan pathway.
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Methotrexate Pathway, Pharmacokinetics
Diagramatic representation of uptake, transport and elimination of methotrexate.
-
Pravastatin Pathway, Pharmacokinetics
Drug-specific representation of the candidate genes involved in transport, metabolism and clearance.
-
Rosiglitazone Pharmacokinetic Pathway
Rosiglitazone is transported from hepatic sinusoids into hepatocytes -- a process mediated by the organic anion transporting polypeptide, where is is metabolized by cytochrome p450 2C8 and 2C9.
-
Rosuvastatin Pathway, Pharmacokinetics
Drug-specific representation of the candidate genes involved in transport, metabolism and clearance.
-
Statin Pathway - Generalized, Pharmacokinetics
Representation of the superset of all genes involved in the transport, metabolism and clearance of statin class drugs.
External Pathways
Links to non-PharmGKB pathways.
Datasets
- experiment_slco1b1_exon_1.xml
- FXR*1B Genotype Is Associated with Reduced Hepatic FXR Target Gene Expression
- Genetic Variants in Statin associated Adverse Events
- Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
- SLCO1B1 Exon 10 Resequencing
- SLCO1B1 Exon 2
- SLCO1B1 Exon 3
- SLCO1B1 Exon 4
- SLCO1B1 Exon 5
- SLCO1B1 Exon 6
- SLCO1B1 Exon 7
- SLCO1B1 Exon 8
- SLCO1B1 Exon 9
- The Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Genome Wide Association Study (GWAS) of Statin-Induced Myopathy. dbGaP ID: phs000141.v1.p1
Downloads
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LinkOuts
- UniProtKB:
- Q05CV5_HUMAN (Q05CV5)
- SO1B1_HUMAN (Q9Y6L6)
- Ensembl:
- ENSG00000134538
- GenAtlas:
- SLCO1B1
- GeneCard:
- GC12P021284 (10599)
- SOURCE:
- SLCO1B1
- MutDB:
- SLCO1B1
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.