- Clinical PGx
- PGx Research
- Overview
- Haplotypes
- Pathways
- Is Related To
- Publications
- Downloads/LinkOuts
PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.
PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.
| Position ? | Drug ? | Relevance ? |
Strength of Evidence ? |
||
|---|---|---|---|---|---|
Download a summary of all Clinical Annotations available.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
PharmGKB contains no genetic tests for this gene. To report genetic tests, click here.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.
Links in the "Drugs" column lead to PharmGKB Drug Pages.
|
Variant?
(build 132) |
Alternate Names ? | Drugs ? |
Alleles
?
(+ chr strand) |
Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|
| rs17222589 |
C > T
|
Missense |
Thr486Ile
|
|||
| rs17222723 | ABCC2 rs8187694, MRP2 Val1188Glu, c.3563T>A, g.52400460T>A, g.58534T>A, p.Val1188Glu |
T > A
|
Missense |
Val1188Glu
|
||
| rs2273697 | ABCC2: c.1249G>A, ABCC2:1249G>A, ABCC2:V417I, ABCC2:c.1249G>A, c.1249G>A, g.26353G>A, g.52368279G>A, p.V417I, p.Val417Ile |
G > A
|
Missense |
Val417Ile
|
||
| rs2804398 |
A > T
|
Intronic | ||||
| rs2804400 |
C > T
|
Intronic | ||||
| rs3740066 | ABCC2: 3972C>T, ABCC2:3972C>T, I1324I, c.3972C>T, g.52408671C>T, g.66745C>T |
C > T
|
Synonymous |
Ile1324Ile
|
||
| rs3758395 |
T > C
|
Intronic | ||||
| rs4148396 |
T > C
|
Intronic | ||||
| rs7080681 |
G > A
|
Missense |
Arg353His
|
|||
| rs717620 | ABCC2: 5'UTR, ABCC2:(-24)C>T, c.-24C>T, g.5116C>T, g.52347042C>T, mRNA 118C>T |
C > G
C > T
C > A
|
5' Flanking | |||
| rs8187710 | ABCC2 rs8187710, MRP2 Cys1515Tyr, c.4544G>A, g.52415758G>A, g.73832G>A, p.Cys1515Tyr |
G > A
|
Missense |
Cys1515Tyr
|
Overview
| Alternate Names: | ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 2; ABCC2; ATP-binding cassette sub-family C (CFTR\/MRP) member 2; ATP-binding cassette sub-family C member 2; Human canalicular multispecific organic anion transporter (cMOAT) mRNA, complete cds.; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; MRP2; MULTISPECIFIC ORGANIC ANION TRANSPORTER, CANALICULAR; CMOAT; OTTHUMP00000020267; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter; canalicular multispecific organic anion transporter 1; multidrug resistance-associated protein 2 |
|---|---|
| Alternate Symbols: | ABC30; CMOAT; DJS; KIAA1010; MRP2; U63970.1; cMRP |
| Haplotypes: | ABCC2 H1; ABCC2 H2; ABCC2 H9; ABCC2 H10; ABCC2 H12 |
| PharmGKB Accession Id: | PA116 |
Details
| Cytogenetic Location: | chr10 : q24.2 - q24.2 |
|---|---|
| GP mRNA Boundary†: | chr10 : 101542463 - 101611662 |
| GP Gene Boundary†: | chr10 : 101532463 - 101614662 |
| Strand: | plus |
| Product Name: | No data available |
All alleles are displayed on the positive chromosomal strand.
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
-
Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
Drug-specific representation of the candidate genes involved in transport, metabolism and clearance.
-
Carbamazepine Pathway, Pharmacokinetics
Stylized liver cell depicting candidate genes involved in the pharmacokinetics of carbamazepine.
-
Codeine and Morphine Pathway, Pharmacokinetics
Representation of the candidate genes involved in metabolism of codeine and morphine.
-
Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
Representation of the candidate genes involved in the action of doxorubicin in a stylized cancer cell.
-
Doxorubicin Pathway, Pharmacokinetics
Diagrammatic representation of the transport and metabolism of doxorubicin.
-
Irinotecan Pathway, Pharmacodynamics
Model non-tissue specific cancer cell displaying genes which may be involved in the irinotecan pathway.
-
Irinotecan Pathway, Pharmacokinetics
Model human liver cell showing blood, bile and intestinal compartments, indicating tissue specific involvement of genes in the irinotecan pathway.
-
Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
Representation of candidate genes involved in the metabolism of lamivudine and its mechanism of antiviral action.
-
Methotrexate Pathway
Methotrexate cellular disposition and effects
-
Methotrexate Pathway, Pharmacokinetics
Diagramatic representation of uptake, transport and elimination of methotrexate.
-
Platinum Pathway
Representation of the candidate genes involved in the metabolism of platinum containing drugs.
-
Pravastatin Pathway, Pharmacokinetics
Drug-specific representation of the candidate genes involved in transport, metabolism and clearance.
-
Statin Pathway - Generalized, Pharmacokinetics
Representation of the superset of all genes involved in the transport, metabolism and clearance of statin class drugs.
-
Tenofovir/Adefovir Pathway, Pharmacokinetics
Representation of candidate genes involved in renal elimination of tenofovir and adefovir and their mechanism of action in an infected kidney cell
-
Vinka Alkaloid Pathway, Pharmacokinetics
Representation of the genes involved in the metabolism, transport, and downstream effects of the vinca alkaloid vincristine.
External Pathways
Links to non-PharmGKB pathways.
PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.
Curated Information ?
| Evidence | Drug Class |
|---|---|
| antiepileptics | |
| hmg coa reductase inhibitors |
Curated Information ?
Publications related to ABCC2: 87
Datasets
LinkOuts
- UniProtKB:
- MRP2_HUMAN (Q92887)
- Ensembl:
- ENSG00000023839
- GenAtlas:
- ABCC2
- GeneCard:
- GC10P101532 (1244)
- MutDB:
- ABCC2
- ALFRED:
- LO101621L