Drug/Small Molecule:
ticarcillin

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Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Gene?
2D structure from PubChem
provided by PubChem

Overview

Generic Names
  • Ticarcilina [inn-spanish]
  • Ticarcillin supplement
  • Ticarcilline [inn-french]
  • Ticarcillinum [inn-latin]
Trade Names
Brand Mixture Names
  • Timentin (Ticarcillin + Clavulanate)

PharmGKB Accession Id:
PA451684

Description

An antibiotic derived from penicillin similar to carbenicillin in action.

Source: Drug Bank

Indication

For the treatment of bacterial infections.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis when the bacteria tries to divide, causing death.

Source: Drug Bank

Pharmacology

Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. Ticarcillin is, however, susceptible to degradation by ß-lactamases, and therefore, the spectrum of activity does not normally include organisms which produce these enzymes.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Protein Binding

45%

Source: Drug Bank

Half-Life

1.1 hours

Source: Drug Bank

Toxicity

As with other penicillins, neurotoxic reactions may arise when very high doses of ticarcillin are administered, especially in patients with impaired renal function.

Source: Drug Bank

Chemical Properties

Chemical Formula

C15H16N2O6S2

Source: Drug Bank

Isomeric SMILES

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CSC=C3)C(=O)O)C(=O)O)C

Source: Drug Bank

[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)[C@H](C(O)=O)C1=CSC=C1)C(O)=O

Source: Drug Bank

Canonical SMILES

CC1(C)S[C@@H]2[C@H]

Source: Drug Bank

Average Molecular Weight

384.427

Source: Drug Bank

Monoisotopic Molecular Weight

384.044977634

Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

No related genes are available.

Drug Interactions

Drug Description
ticarcillin Possible antagonism of action (source: Drug Bank)
ticarcillin Possible antagonism of action (source: Drug Bank)
ticarcillin Possible antagonism of action (source: Drug Bank)
ticarcillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ticarcillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ticarcillin The penicillin increases the effect and toxicity of methotrexate (source: Drug Bank)
ticarcillin The penicillin increases the effect and toxicity of methotrexate (source: Drug Bank)
ticarcillin Possible antagonism of action (source: Drug Bank)
ticarcillin Possible antagonism of action (source: Drug Bank)
ticarcillin Possible antagonism of action (source: Drug Bank)
ticarcillin Possible antagonism of action (source: Drug Bank)
amikacin Ticarcillin may reduce the serum concentration of Amikacin. Ticarcillin may inactivate Amikacin in vitro and the two agents should not be administered simultaneously through the same IV line. (source: Drug Bank)
demeclocycline Demeclocycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Demeclocycline. (source: Drug Bank)
doxycycline Doxycycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Doxycycline. (source: Drug Bank)
gentamicin Ticarcillin may reduce the serum concentration of Gentamicin. Ticarcillin may inactivate Gentamicin in vitro and the two agents should not be administered simultaneously through the same IV line. (source: Drug Bank)
kanamycin Ticarcillin may reduce the serum concentration of Kanamycin. Ticarcillin may inactivate Kanamycin in vitro and the two agents should not be administered simultaneously through the same IV line. (source: Drug Bank)
minocycline Minocycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Minocycline. (source: Drug Bank)
neomycin Ticarcillin may reduce the serum concentration of Neomycin. Ticarcillin may inactivate Neomycin in vitro and the two agents should not be administered simultaneously through the same IV line. (source: Drug Bank)
oxytetracycline Oxytetracycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Oxytetracycline. (source: Drug Bank)
streptomycin Ticarcillin may reduce the serum concentration of Streptomycin. Ticarcillin may inactivate Streptomycin in vitro and the two agents should not be administered simultaneously through the same IV line. (source: Drug Bank)
tetracycline Tetracycline may reduce the effect of Ticarcillin by inhibiting bacterial growth. Ticarcillin exerts its effects on actively growing bacteria. To achieve synergism, Ticarcillin should be administered at least 2 hours prior to using Tetracycline. (source: Drug Bank)
tobramycin Ticarcillin may reduce the serum concentration of Tobramycin. Ticarcillin may inactivate Tobramycin in vitro and the two agents should not be administered simultaneously through the same IV line. (source: Drug Bank)

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB01607
ChEBI:
9587
KEGG Compound:
C07139
PubChem Compound:
36921
PubChem Substance:
46505959
9348
ChemSpider:
33876
Therapeutic Targets Database:
DAP000458

Clinical Trials

These are trials that mention ticarcillin and are related to either pharmacogenetics or pharmacogenomics.

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.