Drug/Small Molecule:
hexachlorophene

PharmGKB contains no dosing guidelines for this drug/small molecule. To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this drug/small molecule. To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Gene?
2D structure from PubChem
provided by PubChem

Overview

Generic Names
Trade Names
  • AT-7
  • Acigena
  • Almederm
  • Bilevon
  • Bivelon
  • Compound G-11
  • Cotofilm
  • Dermadex
  • Dial
  • Distodin
  • E-Z Scrub
  • Eleven
  • Exofene
  • Fascol
  • Fesia-Sin
  • Fomac
  • Fostril
  • G-Eleven
  • G-II
  • Gamophen
  • Gamophene
  • Germa-Medica
  • HCP
  • Hexa-Germ
  • Hexabalm
  • Hexachlorofen
  • Hexachlorophane
  • Hexachlorophen
  • Hexachlorophene, Pharma
  • Hexafen
  • Hexascrub
  • Hexazinone
  • Hexide
  • Hexophene
  • Hexosan
  • Isobac
  • Isobac 20
  • Nabac
  • Nabac 25 Ec
  • Neosept V
  • Phiso-Scrub
  • Phisodan
  • Phisohex
  • Pre-Op
  • Rcra Waste Number U132
  • Ritosept
  • Scrubteam Surgical Spongebrush
  • Septi-Soft
  • Septisol
  • Septofen
  • Soy-Dome
  • Ster-Zac
  • Steral
  • Steraskin
  • Surgi-Cen
  • Surgi-Cin
  • Surofene
  • Tersaseptic
  • Trichlorophene
  • Turgex
Brand Mixture Names
  • Fosteen Dermatologic Shampoo (Hexachlorophene + Lanolin + Salicylic Acid + Sulfur)
  • Hexaphenyl (Hexachlorophene + Isopropyl Alcohol)

PharmGKB Accession Id:
PA449871

Description

A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)

Source: Drug Bank

Indication

For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.

Source: Drug Bank

Pharmacology

Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Protein Binding

92%

Source: Drug Bank

Absorption

Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.

Source: Drug Bank

Toxicity

Oral, rat LD 50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.

Source: Drug Bank

Chemical Properties

Chemical Formula

C13H6Cl6O2

Source: Drug Bank

Isomeric SMILES

C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl

Source: Drug Bank

OC1=C(CC2=C(O)C(Cl)=CC(Cl)=C2Cl)C(Cl)=C(Cl)C=C1Cl

Source: Drug Bank

Canonical SMILES

OC1=C(CC2=C(O)C(Cl)=CC(Cl)=C2Cl)C(Cl)=C(Cl)C=C1Cl

Source: Drug Bank

Average Molecular Weight

406.904

Source: Drug Bank

Monoisotopic Molecular Weight

403.849895678

Source: Drug Bank

LinkOuts

Web Resource:
Wikipedia
National Drug Code Directory:
0024-1535-02
DrugBank:
DB00756
KEGG Compound:
C08039
KEGG Drug:
D00859
PubChem Compound:
3598
PubChem Substance:
149191
46505858
Drugs Product Database (DPD):
2017733
ChemSpider:
3472
Therapeutic Targets Database:
DAP001050
FDA Drug Label at DailyMed:
e9c6f5b4-8374-491a-9b7c-fe008f20e3d1

Clinical Trials

These are trials that mention hexachlorophene and are related to either pharmacogenetics or pharmacogenomics.

Common Searches

Search PubMed
Search Medline Plus
Search PubChem
Search CTD

Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.