Drug/Small Molecule:
ethinyl estradiol

PharmGKB contains no dosing guidelines for this drug/small molecule. To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB gathers information regarding PGx on FDA drug labels from the FDA's "Table of Pharmacogenomic Biomarkers in Drug Labels", and from FDA-approved FDA and EMA-approved (European Medicines Agency) EMA labels brought to our attention. Excerpts from the label and downloadable highlighted label PDFs are manually curated by PharmGKB.

Please note that some drugs may have been removed from or added to the FDA's "Table of Pharmacogenomic Biomarkers in Drug Labels" without our knowledge. We periodically check the table for additions to this table and update PharmGKB accordingly.

There is currently no such list for European drug labels - we are working with the EMA to establish a list of European Public Assessment Reports (EPAR)s that contain PGx information. We are constructing this list by initially searching for drugs for which we have PGx-containing FDA drug labels - of these 44 EMA EPARs were identified and are being curated for pgx information.

We welcome any information regarding drug labels containing PGx information approved by the FDA, EMA or other Medicine Agencies around the world - please contact feedback.


last updated 12/17/2013

FDA Label for drospirenone, ethinyl estradiol and CYP2D6

This label is on the FDA Biomarker List
Informative PGx

Summary

The FDA-approved drug label for drospirenone and ethinyl estradiol (Yaz) notes that in vitro studies showed an inhibitory effect of drospirenone on the turnover of model substrates of CYP1A1, CYP2C9, CYP2C19 and CYP3A4. However, in vivo studies using omeprazole as a marker substrate showed that drospirenone has little propensity to interact to a significant extent with cytochrome P450 enzymes at a clinical dose level.

Annotation

Drospirenone and ethinyl estradiol (Yaz) is a combined oral contraceptive drug. The FDA-approved drug label notes that in vitro studies showed that drospirenone had an inibitory influence on the turnover of model substrates of CYP1A1, CYP2C9, CYP2C19 and CYP3A4, but no influence on model substrates of CYP1A2 and CYP2D6. However, in vivo studies using omeprazole as a marker substrate showed no influence of drospirenone on clearance of omeprazole. This suggests that drospirenone has little propensity to interact with cytochrome P450 enzymes.

Excerpt from the drospirenone and ethinyl estradiol (Yaz) drug label:

In in vitro studies DRSP [drospirenone] did not affect turnover of model substrates of CYP1A2 and CYP2D6, but had an inhibitory influence on the turnover of model substrates of CYP1A1, CYP2C9, CYP2C19 and CYP3A4 with CYP2C19 being the most sensitive enzyme.

The potential effect of DRSP on CYP2C19 activity was investigated in a clinical pharmacokinetic study using omeprazole as a marker substrate. In the study with 24 postmenopausal women including 12 women with homozygous (wild type) CYP2C19 genotype and 12 women with heterozygous CYP2C19 genotype the daily oral administration of 3 mg DRSP for 14 days did not affect the oral clearance of omeprazole (40 mg, single oral dose). Based on the available results of in vivo and in vitro studies it can be concluded that, at clinical dose level, DRSP shows little propensity to interact to a significant extent with cytochrome P450 enzymes.

For the complete drug label text with sections containing pharmacogenetic information highlighted, see the drospirenone and ethinyl estradiol drug label.

*Disclaimer: The contents of this page have not been endorsed by the FDA and are the sole responsibility of PharmGKB.

Full label available at DailyMed

Genes and/or phenotypes found in this label

  • CYP1A1
    • Precautions section
    • source: FDA Label
  • CYP1A2
    • Precautions section
    • source: FDA Label
  • CYP2C19
    • Precautions section
    • source: FDA Label
  • CYP2C9
    • Precautions section
    • source: FDA Label
  • CYP2D6
    • Precautions section
    • source: FDA Label
  • CYP3A4
    • Drug interactions section, Clinical pharmacology section, Precautions section, metabolism/PK
    • source: FDA Label

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Gene?
2D structure from PubChem
provided by PubChem

Overview

Generic Names
  • 17 alpha-Ethinylestradiol
  • 17 alpha-Ethynylestradiol
  • 17 alpha-Ethynyloestradiol
  • Aethinyloestradiolum
  • Aethinyoestradiol [German]
  • EE
  • EO
  • Ethinyl-Oestranol
  • Ethinylestradiolum [INN-Latin]
  • Ethinylestriol
  • Ethinyloestradiol
  • Ethynylestradiol
  • Ethynyloestradiol
  • Etinilestradiol [INN-Spanish]
  • ethynyl estradiol
Trade Names
  • Amenoron
  • Amenorone
  • Anovlar
  • Cyclosa
  • Dicromil
  • Diognat-E
  • Diogyn E
  • Diogyn-E
  • Diprol
  • Dyloform
  • Ertonyl
  • Esteed
  • Estigyn
  • Eston-E
  • Estopherol
  • Estoral
  • Estorals
  • Ethidol
  • Ethinoral
  • Ethy 11
  • Eticyclin
  • Eticyclol
  • Eticylol
  • Etinestrol
  • Etinestryl
  • Etinoestryl
  • Etistradiol
  • Etivex
  • Follicoral
  • Ginestrene
  • Gynolett
  • Halodrin
  • Inestra
  • Kolpolyn
  • Linoral
  • Marvelon
  • Menolyn
  • Mercilon
  • Microfollin
  • Neo-Estrone
  • Nogest-S
  • Novestrol
  • Oradiol
  • Orestralyn
  • Orestrayln
  • Ortho-Cyclen
  • Oviol
  • Primogyn
  • Primogyn C
  • Primogyn M
  • Progynon C
  • Progynon M
  • Prosexol
  • Spanestrin
  • Varnoline
  • Ylestrol
Brand Mixture Names
  • Alesse 21 Tablets (Ethinyl Estradiol + Levonorgestrel)
  • Alesse 28 Tablets (Ethinyl Estradiol + Levonorgestrel)
  • Brevicon (Ethinyl Estradiol + Norethindrone)
  • Cyclen (Ethinyl Estradiol + Norgestimate)
  • Demulen 30 (Ethinyl Estradiol + Ethynodiol Diacetate)
  • Demulen 50 (Ethinyl Estradiol + Ethynodiol Diacetate)
  • Diane-35 (Cyproterone Acetate + Ethinyl Estradiol)
  • Evra (Ethinyl Estradiol + Norelgestromin)
  • Femhrt 1/5 (Ethinyl Estradiol + Norethindrone Acetate)
  • Geri Bons Tab (Calcium (Calcium Phosphate (Dibasic)) + Copper + Dl-Methionine + Ethinyl Estradiol + Fatty Acids + Folic Acid + Iodine + Iron Peptonized + Magnesium + Manganese + Methyltestosterone + Nicotinamide + Phosphorus (Calcium Phosphate (Dibasic)) + Pyridoxine Hydrochloride + Thiamine Hydrochloride + Thyroid + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D + Vitamin E)
  • Geri Tabs (Calcium (Calcium Phosphate (Dibasic)) + Copper Sulfate + Dl-Methionine + Ethinyl Estradiol + Folic Acid + Iodine + Iron Peptonized + Magnesium Oxide + Manganese Sulfate + Methyltestosterone + Nicotinamide + Phosphorus (Calcium Phosphate (Dibasic)) + Pyridoxine Hydrochloride + Thiamine Hydrochloride + Thyroid + Vitamin a + Vitamin B12 + Vitamin B2 + Vitamin D + Vitamin E)
  • Lo-Femenal 21 Tablets (Ethinyl Estradiol + Norgestrel)
  • Loestrin 1.5/30 21day Pak (Ethinyl Estradiol + Norethindrone Acetate)
  • Loestrin 1.5/30 28day Pack (Ethinyl Estradiol + Norethindrone Acetate)
  • Marvelon 21 Tab (Desogestrel + Ethinyl Estradiol)
  • Marvelon 28 Tab (Desogestrel + Ethinyl Estradiol)
  • Min-Ovral 21 (Ethinyl Estradiol + Levonorgestrel)
  • Min-Ovral 21 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Min-Ovral 28 (Ethinyl Estradiol + Levonorgestrel)
  • Min-Ovral 28 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Minestrin 1/20 21 (Ethinyl Estradiol + Norethindrone Acetate)
  • Minestrin 1/20 28 (Ethinyl Estradiol + Norethindrone Acetate)
  • Neo Mens Tab (Ethinyl Estradiol + Ethisterone)
  • Nuvaring (Ethinyl Estradiol + Etonogestrel)
  • Ortho Tablets (0.5/35, 1/35, 10/11, 7/7/7) (Ethinyl Estradiol + Norethindrone)
  • Ortho-Cept Tablets (Desogestrel + Ethinyl Estradiol)
  • Ovral 21 Tab (Ethinyl Estradiol + Norgestrel (Norgestrel))
  • Ovral 21 Tablets (Ethinyl Estradiol + Norgestrel (Norgestrel))
  • Ovral 28 Tablets (Ethinyl Estradiol + Norgestrel (Norgestrel))
  • Ovral 28tab (Ethinyl Estradiol + Norgestrel)
  • Preven Tablets (Ethinyl Estradiol + Levonorgestrel)
  • Select 1/35 (Ethinyl Estradiol + Norethindrone)
  • Synphasic 21 Tablets (Ethinyl Estradiol + Norethindrone)
  • Synphasic 28 Tablets (Ethinyl Estradiol + Norethindrone)
  • Synphasic-28 Tablets (Ethinyl Estradiol + Norethindrone)
  • Tri-Cyclen Lo (Ethinyl Estradiol + Norgestimate)
  • Tri-Cyclen Tablets - 21-Day (Ethinyl Estradiol + Norgestimate)
  • Tri-Cyclen Tablets - 28-Day (Ethinyl Estradiol + Norgestimate)
  • Triphasil 21 (Ethinyl Estradiol + Levonorgestrel)
  • Triphasil 21 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Triphasil 28 (Ethinyl Estradiol + Levonorgestrel)
  • Triphasil 28 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Triquilar 21 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Triquilar 28 Tab (Ethinyl Estradiol + Levonorgestrel)
  • Yasmin 21 (Drospirenone + Ethinyl Estradiol)
  • Yasmin 28 (Drospirenone + Ethinyl Estradiol)

PharmGKB Accession Id:
PA449527

Description

A semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in oral contraceptives.

Source: Drug Bank

Indication

For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

Source: Drug Bank

Pharmacology

Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to ethinyl estradiol before it is biologically active. Ethinyl estradiol and norethindrone are used together as an oral contraceptive agent.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Hepatic. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens.

Source: Drug Bank

Protein Binding

97%

Source: Drug Bank

Absorption

Rapid and complete absorption follows oral intake of ethinyl estradiol (bioavailability 43%).

Source: Drug Bank

Half-Life

36 +/- 13 hours

Source: Drug Bank

Toxicity

Oral, mouse LD 50: 1737 mg/kg. Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.

Source: Drug Bank

Chemical Properties

Chemical Formula

C20H24O2

Source: Drug Bank

Isomeric SMILES

C[C@]12CC[C@@H]3c4ccc(cc4CC[C@H]3[C@@H]1CC[C@]2(C#C)O)O

Source: OpenEye

Canonical SMILES

C[C@]12CC[C@H]

Source: Drug Bank

Average Molecular Weight

296.4034

Source: Drug Bank

Monoisotopic Molecular Weight

296.177630012

Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

Drug Targets

Gene Description
ESR1 (source: Drug Bank)
NR1I2 (source: Drug Bank)

Drug Interactions

Drug Description
ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
ethinyl estradiol Decreases the effect of contraceptive (source: Drug Bank)
ethinyl estradiol This product might cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol This anti-infectious agent could decreases the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol The contraceptive increases the effect and toxicity of cyclosporine (source: Drug Bank)
ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
acenocoumarol Increased thrombotic risk due to estrogen (source: Drug Bank)
acenocoumarol Increased thrombotic risk due to estrogen (source: Drug Bank)
aminophylline The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
amobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
amobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
amoxicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
amoxicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ampicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ampicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
amprenavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
amprenavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
anisindione Increased thrombotic risk due to estrogen (source: Drug Bank)
aprepitant Aprepitant could decrease the effect of the oral contraceptive (source: Drug Bank)
aprobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
azlocillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
aztreonam This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
aztreonam This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
bacampicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
bosentan Bosentan decreases the effect of contraceptive (source: Drug Bank)
bosentan Bosentan decreases the effect of contraceptive (source: Drug Bank)
butabarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
butalbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
butalbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
butethal This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
carbamazepine This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
carbamazepine This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
carbenicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
carbenicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
clavulanate This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
cloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
cloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
cyclacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
cyclosporine The contraceptive increases the effect and toxicity of cyclosporine (source: Drug Bank)
cyclosporine The contraceptive increases the effect and toxicity of cyclosporine (source: Drug Bank)
demeclocycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
dicloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
dicumarol Increased thrombotic risk due to estrogen (source: Drug Bank)
dicumarol Increased thrombotic risk due to estrogen (source: Drug Bank)
doxycycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
doxycycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
dyphylline The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
ethotoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
etoricoxib Etoricoxib increases the levels of ethinyl estradiol (source: Drug Bank)
flucloxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
fosphenytoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
griseofulvin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
griseofulvin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
heptabarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
hetacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
hexobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
hexobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
itraconazole This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
itraconazole This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ketoconazole This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ketoconazole This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
lamotrigine The oral contraceptive decreases the effect of lamotrigine (source: Drug Bank)
lamotrigine The oral contraceptive decreases the effect of lamotrigine (source: Drug Bank)
mephenytoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
mephenytoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
methacycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
methohexital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
methylphenobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
methylphenobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
meticillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
mezlocillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
minocycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
minocycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
modafinil Modafinil decreases the effect of contraceptive (source: Drug Bank)
modafinil Modafinil decreases the effect of contraceptive (source: Drug Bank)
nafcillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
nafcillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
nelfinavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
nelfinavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
oxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
oxacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
oxcarbazepine Oxcarbazepine decreases the effect of the contracepitve (source: Drug Bank)
oxcarbazepine Oxcarbazepine decreases the effect of the contracepitve (source: Drug Bank)
oxtriphylline The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
oxytetracycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
oxytetracycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
penicillin g This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
penicillin g This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
pentobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
pentobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
phenobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
phenobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
phenytoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
phenytoin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
pioglitazone Possible loss of contracepitve effect (source: Drug Bank)
pioglitazone Possible loss of contracepitve effect (source: Drug Bank)
piperacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
piperacillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
pivampicillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
prednisolone The estrogenic agent increases the effect of corticosteroid (source: Drug Bank)
prednisolone The estrogenic agent, ethinyl estradiol, may increase the effect of corticosteroid, prednisolone. (source: Drug Bank)
prednisone The estrogenic agent increases the effect of corticosteroid (source: Drug Bank)
prednisone The estrogenic agent, ethinyl estradiol, may increase the effect of corticosteroid, prednisone. (source: Drug Bank)
primidone This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
primidone This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
raloxifene Association not recommended (source: Drug Bank)
raloxifene Association not recommended (source: Drug Bank)
rifabutin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
rifabutin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
rifampin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
rifampin This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
rifapentine This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ritonavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
ritonavir Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
rolitetracycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
secobarbital This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
talbutal This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
tazobactam This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
tetracycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
tetracycline This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
theophylline The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
theophylline The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
ticarcillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ticarcillin This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
tizanidine The contraceptive increases the effect of tizanidine (source: Drug Bank)
tizanidine The contraceptive increases the effect of tizanidine (source: Drug Bank)
topiramate Topiramate decreases the effect of estrogen (source: Drug Bank)
topiramate Topiramate decreases the effect of estrogen (source: Drug Bank)
troglitazone Possible loss of contracepitve effect (source: Drug Bank)
troglitazone Possible loss of contracepitve effect (source: Drug Bank)
ursodeoxycholic acid Estrogens decreases the effect of ursodiol (source: Drug Bank)
warfarin Increased thrombotic risk due to estrogen (source: Drug Bank)
warfarin Increased thrombotic risk due to estrogen (source: Drug Bank)
ethinyl estradiol This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol This anti-infectious agent could decreases the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol The oral contraceptive decreases the effect of lamotrigine (source: Drug Bank)
ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol Modafinil decreases the effect of the contraceptive (source: Drug Bank)
ethinyl estradiol Ritonavir could decrease the contraceptive efficacy (source: Drug Bank)
ethinyl estradiol Oxcarbazepine decreases the effect of the contraceptive (source: Drug Bank)
ethinyl estradiol This anti-infectious agent could decreases the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol Possible loss of contraceptive effect (source: Drug Bank)
ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol The estrogenic agent increases the effect of the corticosteroid (source: Drug Bank)
ethinyl estradiol The estrogenic agent increases the effect of corticosteroid (source: Drug Bank)
ethinyl estradiol This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol Association not recommended (source: Drug Bank)
ethinyl estradiol This product may cause a slight decrease of the contraceptive effect (source: Drug Bank)
ethinyl estradiol This product may cause a slight decrease of contraceptive effect (source: Drug Bank)
ethinyl estradiol This anti-infectious agent could decrease the effect of the oral contraceptive (source: Drug Bank)
ethinyl estradiol The contraceptive increases the effect and toxicity of theophylline (source: Drug Bank)
ethinyl estradiol The contraceptive increases the effect of tizanidine (source: Drug Bank)

Publications related to ethinyl estradiol: 6

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
PharmGKB summary: very important pharmacogene information for CYP2B6. Pharmacogenetics and genomics. 2010. Thorn Caroline F, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Analytical and bioanalytical chemistry. 2008. Zanger Ulrich M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance. Pharmacogenomics. 2007. Zanger Ulrich M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annual review of pharmacology and toxicology. 2003. Ding Xinxin, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers. Clinical pharmacology and therapeutics. 2002. Robertson Philmore, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Med-psych drug-drug interactions update. Psychosomatics. 2002. Armstrong Scott C, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00977
ChEBI:
4903
KEGG Compound:
C07534
KEGG Drug:
D00554
PubChem Compound:
5991
PubChem Substance:
148835
46508618
Drugs Product Database (DPD):
28231
ChemSpider:
5770
Therapeutic Targets Database:
DAP001018

Clinical Trials

These are trials that mention ethinyl estradiol and are related to either pharmacogenetics or pharmacogenomics.

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.