Drug/Small Molecule:
ethynodiol diacetate

PharmGKB contains no dosing guidelines for this drug/small molecule. To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this drug/small molecule. If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Gene?
2D structure from PubChem
provided by PubChem

Overview

Generic Names
  • Ethinodiol Diacetate
  • Ethynodiol
  • Etynodiol
Trade Names
  • Cervicundin
  • Continuin
  • Femulen
  • Luteonorm
  • Luto-Metrodiol
  • Metrodiol
  • Metrodiol Diacetate
  • Metrulen
  • Ovulen
  • Ovulen 50
Brand Mixture Names
  • Demulen 30 (21 Day Pack) (Ethinyl Estradiol + Ethynodiol Diacetate)
  • Demulen 30 (28 Day Pack) (Ethinyl Estradiol + Ethynodiol Diacetate)
  • Demulen 50 (21 Day Pack) (Ethinyl Estradiol + Ethynodiol Diacetate)
  • Demulen 50 (28 Day Pack) (Ethinyl Estradiol + Ethynodiol Diacetate)

PharmGKB Accession Id:
PA164749157

Description

A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.

Source: Drug Bank

Indication

For the prevention of pregnancy in women who elect to use this product as a method of contraception.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Ethynodiol Diacetate will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

Source: Drug Bank

Pharmacology

Ethynodiol Diacetate is used as a female contraceptive. Ethynodiol Diacetate is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Ethynodiol Diacetate tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Protein Binding

50-85%

Source: Drug Bank

Chemical Properties

Chemical Formula

C24H32O4

Source: Drug Bank

Isomeric SMILES

CC(=O)O[C@H]1CC[C@@H]2[C@H]3CC[C@]4([C@H]([C@@H]3CCC2=C1)CC[C@]4(C#C)OC(=O)C)C

Source: Drug Bank

[H][C@@]12CC[C@@](OC(C)=O)(C#C)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CC[C@H](OC(C)=O)C=C3CC[C@@]21[H]

Source: Drug Bank

Canonical SMILES

CC(=O)O[C@H]1CC[C@@H]

Source: Drug Bank

Average Molecular Weight

384.5085

Source: Drug Bank

Monoisotopic Molecular Weight

384.230059512

Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Drug Targets

Gene Description
ESR1 (source: Drug Bank)
PGR (source: Drug Bank)

Drug Interactions

Drug Description
ethynodiol diacetate Thiopental may decrease the effect of Ethynodiol diacetate. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy. (source: Drug Bank)
ethynodiol diacetate Thiopental may decrease the effect of Ethynodiol diacetate. Contraceptive failure may occur. Alternative nonhomomonal contraception should be used during concomitant therapy. (source: Drug Bank)
ethynodiol diacetate Oral Tretinoin may decrease the effect of oral contraceptive, Ethynodiol Diacetate. An alternate form of contraception should be used during concomitant therapy. (source: Drug Bank)
ethynodiol diacetate Ethynodiol diacetate may alter the anticoagulant effect of warfarin. Concomitant therapy should be avoided. Monitor for changes in coagulation status if ethynodiol diacetate is initiated, discontinued or dose (source: Drug Bank)

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00823
ChEBI:
31580
KEGG Compound:
C12724
KEGG Drug:
D01294
PubChem Compound:
9270
PubChem Substance:
46506993
583113
Drugs Product Database (DPD):
469327
ChemSpider:
8913
Therapeutic Targets Database:
DAP000856

Clinical Trials

These are trials that mention ethynodiol diacetate and are related to either pharmacogenetics or pharmacogenomics.

Common Searches

Search PubMed
Search Medline Plus
Search PubChem
Search CTD

Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.