Drug/Small Molecule:
benzyl benzoate

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Gene?
2D structure from PubChem
provided by PubChem

Overview

Generic Names
Trade Names
  • Ascabin
  • Ascabiol
  • Benylate
  • Benzoic acid benzyl ester
  • Benzoic acid, benzyl ester
  • Benzoic acid, phenylmethyl ester
  • Benzyl alcohol benzoic ester
  • Benzyl benzenecarboxylate
  • Benzyl ester
  • Benzyl phenylformate
  • Benzylester kyseliny benzoove
  • Benzylets
  • Colebenz
  • Novoscabin
  • Peruscabin
  • Scabagen
  • Scabanca
  • Scabide
  • Scabiozon
  • Scabitox
  • Scobenol
  • Vanzoate
  • Venzoate
  • Venzonate
Brand Mixture Names
  • Benzyl benzoate 99+ %
  • Dermadex Crm (Benzoic Acid + Benzyl Benzoate + Lindane + Salicylic Acid + Zinc Oxide + Zinc Undecylenate)

PharmGKB Accession Id:
PA164748881

Description

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

Source: Drug Bank

Indication

Used to kill lice and the mites responsible for the skin condition scabies.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.

Source: Drug Bank

Pharmacology

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.

Source: Drug Bank

Absorption

No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.

Source: Drug Bank

Toxicity

Oral, rabbit: LD 50 = 1680 mg/kg; Skin, rabbit: LD 50 = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.

Source: Drug Bank

Chemical Properties

Chemical Formula

C14H12O2

Source: Drug Bank

Isomeric SMILES

c1ccc(cc1)COC(=O)c2ccccc2

Source: OpenEye

Canonical SMILES

O=C(OCC1=CC=CC=C1)C1=CC=CC=C1

Source: Drug Bank

Average Molecular Weight

212.2439

Source: Drug Bank

Monoisotopic Molecular Weight

212.083729628

Source: Drug Bank

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00676
KEGG Drug:
D01138
PubChem Compound:
2345
PubChem Substance:
46508023
ChemSpider:
13856959

Clinical Trials

These are trials that mention benzyl benzoate and are related to either pharmacogenetics or pharmacogenomics.

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.