Drug/Small Molecule:
oxamniquine

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PharmGKB has no annotated drug labels with pharmacogenomic information for this drug/small molecule. If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

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The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Gene?
2D structure from PubChem
provided by PubChem

Overview

Generic Names
Trade Names
  • Mansil
  • Vansil
Brand Mixture Names

PharmGKB Accession Id:
PA164748782

Description

An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Extra Pharmacopoeia, 31st ed, p121)

Source: Drug Bank

Indication

For treatment of Schistosomiasis caused by Schistosoma mansoni

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Oxamniquine may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into an ester (probably acetate, phosphate, or sulfate). Subsequently, the ester spontaneously dissociates, the resulting electrophilic reactant is capable of alkylation of schistosome DNA.

Source: Drug Bank

Pharmacology

Oxamniquine is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release egg.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Probably hepatic

Source: Drug Bank

Absorption

Well absorbed orally

Source: Drug Bank

Half-Life

1-2.5 hours

Source: Drug Bank

Chemical Properties

Chemical Formula

C14H21N3O3

Source: Drug Bank

Isomeric SMILES

CC(C)NCC1CCc2cc(c(cc2N1)N(=O)=O)CO

Source: OpenEye

Canonical SMILES

CC(C)NCC1CCC2=CC(CO)=C(C=C2N1)[N+]([O-]

Source: Drug Bank

Average Molecular Weight

279.3348

Source: Drug Bank

Monoisotopic Molecular Weight

279.158291553

Source: Drug Bank

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB01096
KEGG Compound:
C07341
KEGG Drug:
D00460
PubChem Compound:
4612
PubChem Substance:
46508789
9548
ChemSpider:
4451
Therapeutic Targets Database:
DAP000992

Clinical Trials

These are trials that mention oxamniquine and are related to either pharmacogenetics or pharmacogenomics.

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.