Drug/Small Molecule:
diphenidol

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

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The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Gene?
2D structure from PubChem
provided by PubChem

Overview

Generic Names
  • Difenidol
  • Difenidol HCl
  • Difenidol hydrochloride
  • Difenidolo [DCIT]
  • Difenidolum [INN-Latin]
  • Diphenidol HCl
  • Diphenidol hydrochloride
Trade Names
  • Ansmin
  • Avomol
  • Celmidol
  • Cephadol
  • Cerrosa
  • Maniol
  • Nometic
  • Satanolon
  • Verterge
  • Vontrol
  • Yesdol
Brand Mixture Names

PharmGKB Accession Id:
PA164746037

Description

Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. Diphenidol overdose may result in serious toxicity in children.

Source: Drug Bank

Indication

For use in the prevention and symptomatic treatment of peripheral (labyrinthine) vertigo and associated nausea and vomiting that occur in such conditions as Meniere's disease and surgery of the middle and inner ear. Also for the control of nausea and vomiting associated with postoperative states, malignant neoplasms, labyrinthine disturbances, antineoplastic agent therapy, radiation sickness, and infectious diseases.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

The mechanism by which diphenidol exerts its antiemetic and antivertigo effects is not precisely known. It is thought to diminish vestibular stimulation and depress labyrinthine function and as an antimuscarinic agent. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect. Diphenidol has no significant sedative, tranquilizing, or antihistaminic action. It has a weak peripheral anticholinergic effect.

Source: Drug Bank

Pharmacology

Diphenidol is used for control of nausea and vomiting. It has an antivertigo effect on the vestibular apparatus, inhibiting the chemoreceptor trigger zone to control nausea and vomiting, thus preventing motion sickness.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Absorption

Well absorbed from gastrointestinal tract following oral administration.

Source: Drug Bank

Half-Life

4 hours

Source: Drug Bank

Toxicity

Symptoms of overdose include drowsiness (severe); shortness of breath or troubled breathing; unusual tiredness or weakness (severe).

Source: Drug Bank

Chemical Properties

Chemical Formula

C21H27NO

Source: Drug Bank

Isomeric SMILES

C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O

Source: Drug Bank

OC(CCCN1CCCCC1)(C1=CC=CC=C1)C1=CC=CC=C1

Source: Drug Bank

Canonical SMILES

OC(CCCN1CCCCC1)(C1=CC=CC=C1)C1=CC=CC=C1

Source: Drug Bank

Average Molecular Weight

309.4452

Source: Drug Bank

Monoisotopic Molecular Weight

309.209264491

Source: Drug Bank

LinkOuts

DrugBank:
DB01231
ChEBI:
4638
KEGG Compound:
C06961
KEGG Drug:
D03858
PubChem Compound:
3055
PubChem Substance:
46506486
9175
ChemSpider:
2947
Therapeutic Targets Database:
DAP001133

Clinical Trials

These are trials that mention diphenidol and are related to either pharmacogenetics or pharmacogenomics.

Common Searches

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.