Drug Class:
Tumor necrosis factor alpha (TNF-alpha) inhibitors

PharmGKB contains no dosing guidelines for this drug class. To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this drug class. To report a drug label with PGx, click here.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Gene?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

Gene ? Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs10499194 138002637C>T, 42172094C>T
C > T
Not Available
No VIP available CA VA
rs10919563 1382-304G>A, 1865-304G>A, 198700442G>A, 50189084G>A, 97218G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs10945919 164186677A>G, 68356134A>G
A > G
Not Available
No VIP available No Clinical Annotations available VA
rs11586238 117263138C>G, 87235056C>G
C > G
Not Available
No VIP available No Clinical Annotations available VA
rs13031237 395-7883G>T, 39958016G>T, 61136129G>T
G > T
Intronic
No VIP available No Clinical Annotations available VA
rs13393173 169389091G>A, 171-15015G>A, 19598509G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs1568885 13627531T>A, 13637531T>A
T > A
Not Available
No VIP available CA VA
rs1799724 *1012C>T, -1037C>T, 2828023C>T, 2836120C>T, 2873283C>T, 2885366C>T, 2922188C>T, 3052098C>T, 31482482C>T, 31542482C>T, 4133C>T, 7607C>T, TNF:-850C-T, TNF:-857 C/T
C > T
5' Flanking
No VIP available CA VA
rs1800629 -308, -308G>A, -488G>A, 2828572G>A, 2836669G>A, 2873832G>A, 2885915G>A, 2922737G>A, 3052647A>A, 31483031G>A, 31543031G>A, 4682G>A, 8156G>A, TNF alpha -308G/A, TNF2, TNF:, TNF:-308 G/A, TNF:-308G/A
G > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs1800795 -237C>G, 22756645C>G, 22766645C>G, 4880C>G, 50-321G>C
C > G
Intronic
No VIP available No Clinical Annotations available VA
rs1813443 100011011G>C, 1359-50847G>C, 1581-50847G>C, 3573427G>C
G > C
Intronic
No VIP available No Clinical Annotations available VA
rs1980422 204610396C>T, 54819814C>T
C > T
Not Available
No VIP available No Clinical Annotations available VA
rs2104286 10228A>G, 6039045T>C, 6099045T>C, 64+5006A>G
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs2228145 1066+4514A>C, 1066+4514A>T, 1073A>C, 1073A>T, 154426970A>C, 154426970A>T, 54302A>C, 54302A>T, 5915612A>C, 5915612A>T, Asp358Ala, Asp358Val
A > T
A > C
Intronic
Asp358Ala
No VIP available No Clinical Annotations available VA
rs2476601 114377568A>A, 114377568A>G, 1693C>C, 1693C>T, 1858C>C, 1858C>T, 41808C>C, 41808C>T, 84349486A>A, 84349486A>G, Arg565=, Arg620=
A > G
Missense
Arg620Trp
No VIP available No Clinical Annotations available VA
rs2736340 11343973C>T, 3819324C>T
C > T
Not Available
No VIP available No Clinical Annotations available VA
rs2812378 -197C>T, 34700260G>A, 34710260G>A
G > A
5' Flanking
No VIP available CA VA
rs2814707 27526397C>T, 27536397C>T
C > T
Not Available
No VIP available No Clinical Annotations available VA
rs3087243 *1384G>A, *1421G>A, 11411G>A, 204738919G>A, 54948337G>A
G > A
3' Flanking
No VIP available No Clinical Annotations available VA
rs3218253 -34+1055C>T, 16935379G>A, 37544810G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs3761847 -1638C>T, -366+1153C>T, 123690239G>A, 52854771G>A, 6213C>T
G > A
5' Flanking
No VIP available CA VA
rs3794271 13620217G>A, 20860093G>A, 404+1078G>A, 50+1078G>A
G > A
Intronic
No VIP available CA VA
rs3849942 27533281T>C, 27543281T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs394581 159482521C>T, 63651978C>T
C > T
Not Available
No VIP available CA VA
rs437943 2531460T>C, 35372098T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs4411591 198-25872C>T, 6540117C>T, 6550117C>T
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs4750316 6333260C>G, 6393260C>G, 978C>G
C > G
3' Flanking
No VIP available No Clinical Annotations available VA
rs4810485 14944039T>G, 44747947T>G, 51+914T>G, 6042T>G
T > G
Intronic
No VIP available No Clinical Annotations available VA
rs548234 106568034C>T, 10737491C>T
C > T
Not Available
No VIP available CA VA
rs6028945 38820805G>T, 9016897G>T
G > T
Not Available
No VIP available CA VA
rs6071980 38868576T>C, 9064668T>C
T > C
Not Available
No VIP available CA VA
rs6138150 23787009T>C, 23847009T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs6822844 123509421G>T, 48057142G>T
G > T
Not Available
No VIP available No Clinical Annotations available VA
rs6920220 138006504G>A, 42175961G>A
G > A
Not Available
No VIP available CA VA
rs7046653 -198-35221T>C, 27480967A>G, 27490967A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs7574865 191964633T>G, 274-23582A>C, 42174051T>G, 56293A>C
T > G
Intronic
No VIP available CA VA
rs774359 *530A>G, 17816A>G, 27551049T>C, 27561049T>C, 665+534A>G
T > C
Intronic
No VIP available CA VA
rs854547 *4241G>A, 32956699G>A, 391908G>A, 94923856G>A
G > A
3' UTR
No VIP available CA VA
rs854548 *6205A>G, 32958663A>G, 33065T>C, 393872A>G, 94925820A>G
A > G
3' Flanking
No VIP available CA VA
rs854555 28494T>G, 32963234A>C, 909+1126T>G, 94930391A>C
A > C
Intronic
No VIP available CA VA
rs868856 -198-33505T>C, 27479251A>G, 27489251A>G
A > G
Intronic
No VIP available CA VA
rs928655 1469-78G>A, 59821492G>A, 89849574G>A
G > A
Intronic
No VIP available CA VA
rs983332 58104298G>T, 88132380G>T
G > T
Not Available
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Generic Names
Trade Names
Brand Mixture Names

PharmGKB Accession Id:
PA164713366

Other Vocabularies

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

No related drugs are available.

Curated Information ?

Publications related to Tumor necrosis factor alpha (TNF-alpha) inhibitors: 12

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The classification and diagnostic criteria of ankylosing spondylitis. Journal of autoimmunity. 2014. Raychaudhuri Siba P, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of TNF-alpha polymorphism with prediction of response to TNF blockers in spondyloarthritis and inflammatory bowel disease: a meta-analysis. Pharmacogenomics. 2013. Tong Qiang, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis. Pharmacogenomics. 2013. Acosta-Colman Isabel, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis. Annals of the rheumatic diseases. 2012. Umicevic Mirkov Masa, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of Rheumatoid Arthritis Risk Alleles with Response to Anti-TNF Biologics: Results from the CORRONA Registry and Meta-analysis. Inflammation. 2012. Pappas Dimitrios A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
-174G/C IL-6 gene promoter polymorphism predicts therapeutic response to TNF-alpha blockers. Pharmacogenetics and genomics. 2011. Di Renzo Laura, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy. Arthritis and rheumatism. 2010. Cui Jing, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response. Pharmacogenetics and genomics. 2010. Potter Catherine, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis. Rheumatology (Oxford, England). 2010. Hassan Batool, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
TNF-alpha-308 G/A polymorphism and responsiveness to TNF-alpha blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis. The pharmacogenomics journal. 2009. O'Rielly D D, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. Molecular medicine (Cambridge, Mass.). 2008. Liu Chunyu, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis. Rheumatology international. 2006. Lee Young Ho, et al. PubMed

Clinical Trials

These are trials that mention Tumor necrosis factor alpha (TNF-alpha) inhibitors and are related to either pharmacogenetics or pharmacogenomics.

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.