Drug Class:
Antiinflammatory agents, non-steroids

PharmGKB contains no dosing guidelines for this drug class. To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this drug class. If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Gene?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

Gene ? Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA HLA-DRB1 *11:01:01 N/A N/A N/A
No VIP available No Clinical Annotations available VA
rs10306135 -204-2512A>T, -233-2483A>T, -262A>T, 125137695A>T, 175-2512A>T, 20-2483A>T, 54302227A>T, 623-2483A>T, 9467A>T, 95-2483A>T
A > T
Intronic
No VIP available CA VA
rs1057910 1075A>C, 47545517A>C, 47639A>C, 96741053A>C, CYP2C9*3, CYP2C9*3:Ile359Leu, CYP2C9: I359L, CYP2C9:359Ile>Leu, CYP2C9:Ile359Leu, Ile359Leu, mRNA 11A>C
A > C
Missense
Ile359Leu
No VIP available CA VA
rs10757274 1238-316A>G, 22086055A>G, 22096055A>G, 2449-316A>G, 645-1202A>G, 645-16264A>G, 645-24144A>G, 781-16264A>G, 781-24144A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs11662595 *249A>G, 22056970A>G, 353A>G, 3546072A>G, 617A>G, His118Arg, His206Arg
A > G
3' UTR
His118Arg
No VIP available No Clinical Annotations available VA
rs11665084 *45C>T, 194-45C>T, 22056766C>T, 3545868C>T, 413C>T, Ala138Val
C > T
3' UTR
Ala138Val
No VIP available No Clinical Annotations available VA
rs1205 *1082G>A, 11170875C>T, 159682233C>T, 7147G>A
C > T
3' UTR
No VIP available No Clinical Annotations available VA
rs12353214 125161870C>T, 54326402C>T
C > T
Not Available
No VIP available CA VA
rs1611115 -979T>C, 136500515T>C, 3277455T>C, 4031T>C
T > C
5' Flanking
No VIP available CA VA
rs1799971 -11+28644A>G, 118A>G, 154360797A>G, 34162A>G, 397A>G, 47+29103A>G, 58530254A>G, Asn133Asp, Asn40Asp, OPRM1: A118G
A > G
Missense
Asn40Asp
rs20417 -899G>C, 186650321C>G, 38138963C>G, 4239G>C, COX-2 G-765C, PTGS2:-765G>C
C > G
5' Flanking
No VIP available No Clinical Annotations available VA
rs2067474 -1018G>A, -525-493G>A, 175109219G>A, 19920492G>A
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs2071230 *184T>C, 102660959A>G, 13008T>C, 390-2917A>G, 6223375A>G
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs211247 14562646G>C, 33582646G>C
G > C
Not Available
No VIP available CA VA
rs4680 1-5G>A, 19951271G>A, 27009G>A, 3103421G>A, 322G>A, 472G>A, COMP: Val158Met, COMT:Val108Met, Val108Met, Val158Met
G > A
5' Flanking
Val158Met
VIP No Clinical Annotations available No Variant Annotations available
rs5275 *427T>C, 11502T>C, 186643058A>G, 38131700A>G, COX-2 8473T>C, PTGS2 exon10+837T>C, PTGS2: 6498T>C, PTGS2:8473T>C
A > G
3' UTR
No VIP available CA VA
rs6265 196G>A, 220G>A, 241G>A, 27619916C>T, 27679916C>T, 283G>A, 434C>T, 442G>A, 503C>T, 68690G>A, BDNF:Val66Met, Val148Met, Val66Met, Val74Met, Val81Met, Val95Met
C > T
Missense
Val66Met
No VIP available CA VA
rs6275 113283477A>G, 16845893A>G, 67525T>C, 852T>C, 939T>C, His284=, His313=
A > G
Synonymous
His284His
No VIP available CA VA
rs6305 264C>T, 28446622G>A, 47466622G>A, 516C>T, 9548C>T, Asp172=, Asp88=
G > A
Synonymous
Asp88Asp
No VIP available CA VA
rs699 230845794A>G, 24363573A>G, 803T>C, 9543T>C, AGT M235T, AGT Met235Thr, AGT:Met235Thr, angiotensinogen M235T
A > G
Missense
Met268Thr
No VIP available No Clinical Annotations available VA
rs7945189 *579G>A, 102660564C>T, 13403G>A, 390-3312C>T, 6222980C>T
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs901865 -17T>C, 11240707T>C, 11300707T>C
T > C
5' UTR
No VIP available CA VA
rs943580 18293C>T, 230837044G>A, 24354823G>A
G > A
Not Available
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Generic Names
  • NSAID
  • NSAIDs
Trade Names
Brand Mixture Names

PharmGKB Accession Id:
PA164712462

Other Vocabularies

Drugs And Small Molecules

The following have been classified under this therapeutic category:

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

No related drugs are available.

Curated Information ?

Publications related to Antiinflammatory agents, non-steroids: 15

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache. European journal of clinical pharmacology. 2014. Cargnin Sarah, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Variability in histamine receptor genes HRH1, HRH2 and HRH4 in patients with hypersensitivity to NSAIDs. Pharmacogenomics. 2013. Ayuso Pedro, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Methylxanthines and pain. Handbook of experimental pharmacology. 2011. Sawynok Jana. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
PharmGKB summary: very important pharmacogene information for PTGS2. Pharmacogenetics and genomics. 2010. Thorn Caroline F, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CYP2C9*3 Loss-of-Function Allele Is Associated With Acute Upper Gastrointestinal Bleeding Related to the Use of NSAIDs Other Than Aspirin. Clinical pharmacology and therapeutics. 2010. Carbonell N, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs. The American journal of cardiology. 2010. St Germaine Christine G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?. Expert opinion on drug metabolism & toxicology. 2009. Agúndez José A G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury. Hepatology (Baltimore, Md.). 2008. Lucena M Isabel, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms. Gastroenterology. 2007. Pilotto Alberto, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Effects of maternally administered drugs on the fetal and neonatal kidney. Drug safety : an international journal of medical toxicology and drug experience. 2006. Boubred Farid, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2005. Ulrich Cornelia M, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic predisposition to acute gastrointestinal bleeding after NSAIDs use. British journal of pharmacology. 2004. Martínez Carmen, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Med-psych drug-drug interactions update. Psychosomatics. 2002. Armstrong Scott C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Association of HLA-DR11 with the anaphylactoid reaction caused by nonsteroidal anti-inflammatory drugs. The Journal of allergy and clinical immunology. 1999. Quiralte J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268). Drug metabolism and disposition: the biological fate of chemicals. 1998. Coffman B L, et al. PubMed

Clinical Trials

These are trials that mention Antiinflammatory agents, non-steroids and are related to either pharmacogenetics or pharmacogenomics.

Common Searches

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.