Drug/Small Molecule:
atazanavir

PharmGKB contains no dosing guidelines for this drug/small molecule. To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this drug/small molecule. To report a drug label with PGx, click here.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the page.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Gene?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

Gene ? Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No VIP available VA CYP3A5 *1A N/A N/A N/A
No VIP available No VIP available VA CYP3A5 *3A N/A N/A N/A
VIP No Clinical Annotations available No Variant Annotations available
rs1045642 208920T>A, 208920T>C, 25171488A>G, 25171488A>T, 3435T>A, 3435T>C, 87138645A>G, 87138645A>T, ABCB1*6, ABCB1: 3435C>T, ABCB1: C3435T, ABCB1: c.3435C>T, ABCB1:3435C>T, Ile1145=, Ile1145Ile, MDR1 3435C>T, MDR1 C3435T, PGP C3435T, c.3435C>T, mRNA 3853C>T
A > T
A > G
Synonymous
Ile1145Ile
No VIP available No Clinical Annotations available VA
rs2472677 -22-7659C>T, 119518417C>T, 24087C>T, 26013563C>T, 96-7659C>T, NR1I2:63396C>T, PXR 63396C>T
C > T
Intronic
rs8175347 233760235_233760236TA[5][6][7][8], 5-TA insertion in promoter, 7-TA insertion in promoter, 8-TA insertion in promoter, UGT1A1*28, UGT1A1*36, UGT1A1*37, microsatellite, short tandem repeat
(TA)6 > (TA)8
(TA)6 > (TA)5
(TA)6 > (TA)7
Not Available
No VIP available CA VA
rs887829 -364C>T, 175181C>T, 234668570C>T, 61-7110C>T, 614829C>T, 856-7110C>T, 862-7110C>T, 868-7110C>T, UGT1A1(-364)T>C
C > T
Intronic
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138
2D structure from PubChem
provided by PubChem

Overview

Generic Names
  • ATV
  • ATZ
  • Atazanavir sulfate
  • BMS-232632
  • atazanavir
Trade Names
  • Latazanavir
  • Reyataz
  • Zrivada
Brand Mixture Names

PharmGKB Accession Id:
PA10251

Description

Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once-daily (rather than requiring multiple doses per day) and has lesser effects on the patient's lipid profile (the amounts of cholesterol and other fatty substances in the blood). Like other protease inhibitors, it is used only in combination with other HIV medications. The U.S. Food and Drug Administration (FDA) approved atazanavir on June 20, 2003. Wikipedia

Source: Drug Bank

Indication

Used in combination with other antiretroviral agents for the treatment of HIV-1 infection, as well as postexposure prophylaxis of HIV infection in individuals who have had occupational or nonoccupational exposure to potentially infectious body fluids of a person known to be infected with HIV when that exposure represents a substantial risk for HIV transmission.

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

Atazanavir selectively inhibits the virus-specific processing of viral Gag and Gag-Pol polyproteins in HIV-1 infected cells by binding to the active site of HIV-1 protease, thus preventing the formation of mature virions. Atazanavir is not active against HIV-2.

Source: Drug Bank

Pharmacology

Atazanavir (ATV) is an azapeptide HIV-1 protease inhibitor (PI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Atazanavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs. Atazanivir is pharmacologically related but structurally different from other protease inhibitors and other currently available antiretrovirals.

Source: Drug Bank

Food Interaction

Administration with food reduces pharmacokinetic variability.|Food increases product absorption.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Atazanavir is extensively metabolized in humans, primarily by the liver. The major biotransformation pathways of atazanavir in humans consisted of monooxygenation and dioxygenation. Other minor biotransformation pathways for atazanavir or its metabolites consisted of glucuronidation, N-dealkylation, hydrolysis, and oxygenation with dehydrogenation. In vitro studies using human liver microsomes suggested that atazanavir is metabolized by CYP3A.

Source: Drug Bank

Protein Binding

86% bound to human serum proteins (alpha-1-acid glycoprotein and albumin). Protein binding is independent of concentration.

Source: Drug Bank

Absorption

Atazanavir is rapidly absorbed with a T max of approximately 2.5 hours. Administration of atazanavir with food enhances bioavailability and reduces pharmacokinetic variability. Oral bioavailability is 60-68%.

Source: Drug Bank

Half-Life

Elimination half-life in adults (healthy and HIV infected) is approximately 7 hours (following a 400 mg daily dose with a light meal). Elimination half-life in hepatically impaired is 12.1 hours (following a single 400 mg dose).

Source: Drug Bank

Chemical Properties

Chemical Formula

C38H52N6O7

Source: Drug Bank

Isomeric SMILES

CC(C)(C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)[C@H](CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)[C@H](C(C)(C)C)NC(=O)OC)O)NC(=O)OC

Source: Drug Bank

COC(=O)N[C@H](C(=O)N[C@@H](CC1=CC=CC=C1)[C@@H](O)CN(CC1=CC=C(C=C1)C1=NC=CC=C1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C

Source: Drug Bank

Canonical SMILES

COC(=O)N[C@H](C(=O)N[C@@H]

Source: Drug Bank

Average Molecular Weight

704.8555

Source: Drug Bank

Monoisotopic Molecular Weight

704.389748048

Source: Drug Bank

Genes that are associated with this drug in PharmGKB's database based on (1) variant annotations, (2) literature review, (3) pathways or (4) information automatically retrieved from DrugBank, depending on the "evidence" and "source" listed below.

Curated Information ?

EvidenceGene
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
CYP3A5
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
NR1I2
UGT1A1

Drug Targets

Gene Description
ABCB1 (source: Drug Bank)

Drug Interactions

Drug Description
atazanavir The serum concentration of Abacavir may be decreased by protease inhibitors such as Atazanavir. The antiviral response should be closely monitored. (source: Drug Bank)
atazanavir The serum concentration of Abacavir may be decreased by protease inhibitors such as Atazanavir. The antiviral response should be closely monitored. (source: Drug Bank)
atazanavir Increased risk of cardiotoxicity/arrhythmias (source: Drug Bank)
atazanavir Increased risk of cardiotoxicity/arrhythmias (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of tricyclics (source: Drug Bank)
atazanavir Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Atazanavir increases the efect and toxicity of tricyclics (source: Drug Bank)
atazanavir Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, amoxapine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amoxapine if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
acenocoumarol The protease inhibitor increase the anticoagulant effect (source: Drug Bank)
acenocoumarol The protease inhibitor, atazanavir, may increase the anticoagulant effect of acenocoumarol. (source: Drug Bank)
aluminium This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
amiodarone Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank)
amiodarone Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank)
amitriptyline Increases the effect and toxicity of tricyclics (source: Drug Bank)
amitriptyline Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, amitriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amitriptyline if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
amoxapine Increases the effect and toxicity of tricyclics (source: Drug Bank)
amoxapine Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, amoxapine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of amoxapine if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
anisindione The protease inhibitor, atazanavir, may increase the anticoagulant effect of anisindione. (source: Drug Bank)
atorvastatin Increases the effect and toxicity of the statin (source: Drug Bank)
atorvastatin Increases the effect and toxicity of the statin (source: Drug Bank)
bepridil Increases the effect and toxicity of bepridil (source: Drug Bank)
Calcium This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
Calcium This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
cimetidine This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
cimetidine This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
cisapride Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank)
cisapride Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank)
clarithromycin Increases levels of clarithromycin (source: Drug Bank)
clarithromycin Increases levels of clarithromycin (source: Drug Bank)
clomipramine Increases the effect and toxicity of tricyclics (source: Drug Bank)
clomipramine Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
cyclosporine Increases the effect and toxicity of immunosuppressant (source: Drug Bank)
cyclosporine Increases the effect and toxicity of immunosuppressant (source: Drug Bank)
desipramine Increases the effect and toxicity of tricyclics (source: Drug Bank)
desipramine Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
dicumarol The protease inhibitor increases the anticoagulant effect (source: Drug Bank)
dicumarol The protease inhibitor, atazanavir, may increase the anticoagulant effect of dicumarol. (source: Drug Bank)
dihydroergotamine Increases the effect and toxicity of ergot derivative (source: Drug Bank)
dihydroxyaluminium This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
diltiazem Increases the effect and toxicity of diltiazem (source: Drug Bank)
diltiazem Increases the effect and toxicity of diltiazem (source: Drug Bank)
doxepin Increases the effect and toxicity of tricyclics (source: Drug Bank)
doxepin Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
efavirenz Efavirenz decreases the levels/effects of atazanavir (source: Drug Bank)
efavirenz Efavirenz decreases the levels/effects of atazanavir (source: Drug Bank)
ergotamine Increases the effect and toxicity of ergot derivative (source: Drug Bank)
erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib (source: Drug Bank)
erlotinib This CYP3A4 inhibitor increases levels/toxicity of erlotinib (source: Drug Bank)
esomeprazole This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
esomeprazole This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
famotidine This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
famotidine This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
imipramine Increases the effect and toxicity of tricyclics (source: Drug Bank)
imipramine Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
indinavir Increased risk of hyperbilirubinemia with this association (source: Drug Bank)
indinavir Increased risk of hyperbilirubinemia with this association (source: Drug Bank)
irinotecan Increases levels/effect of irinotecan (source: Drug Bank)
irinotecan Increases levels/effect of irinotecan (source: Drug Bank)
lansoprazole This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
lansoprazole This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
lidocaine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank)
lidocaine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank)
lovastatin Increased risk of myopathy/rhabdomyolysis (source: Drug Bank)
lovastatin Increased risk of myopathy/rhabdomyolysis (source: Drug Bank)
Magnesium This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
Magnesium This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
magnesium oxide This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
magnesium sulfate This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
methylergonovine Increases the effect and toxicity of ergot derivative (source: Drug Bank)
methylergonovine Increases the effect and toxicity of ergot derivative (source: Drug Bank)
midazolam Increases the effect and toxicity of benzodiazepine (source: Drug Bank)
midazolam Increases the effect and toxicity of benzodiazepine (source: Drug Bank)
nevirapine Nevirapine decreases levels/effect of atazanavir (source: Drug Bank)
nevirapine Nevirapine decreases levels/effect of atazanavir (source: Drug Bank)
nizatidine This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
nortriptyline Increases the effect and toxicity of tricyclics (source: Drug Bank)
nortriptyline Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
omeprazole This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
omeprazole This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
pantoprazole This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
pantoprazole This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
pimozide The protease inhibitor increases the effect and toxicity of pimozide (source: Drug Bank)
pimozide The protease inhibitor, atazanavir, may increase the effect and toxicity of pimozide. (source: Drug Bank)
protriptyline Increases the effect and toxicity of tricyclics (source: Drug Bank)
protriptyline Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, protriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of protriptyline if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
quinidine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank)
quinidine Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank)
rabeprazole This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
rabeprazole This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
ranitidine This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
ranitidine This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
ranolazine Increased levels of ranolazine- risk of toxicity (source: Drug Bank)
rifabutin Increases levels/toxicity of rifabutin (source: Drug Bank)
rifabutin Increases levels/toxicity of rifabutin (source: Drug Bank)
rifampin Rifampin reduces levels and efficacy of atazanavir (source: Drug Bank)
rifampin Rifampin reduces levels and efficacy of atazanavir (source: Drug Bank)
ritonavir Association with dose adjustment (source: Drug Bank)
ritonavir Association with dose adjustment (source: Drug Bank)
sildenafil Increases the effect and toxicity of sildenafil (source: Drug Bank)
sildenafil Increases the effect and toxicity of sildenafil (source: Drug Bank)
simvastatin Increased risk of myopathy/rhabdomyolysis (source: Drug Bank)
simvastatin Increased risk of myopathy/rhabdomyolysis (source: Drug Bank)
sirolimus Increases the effect and toxicity of immunosuppressant (source: Drug Bank)
sirolimus Increases the effect and toxicity of immunosuppressant (source: Drug Bank)
sodium This gastric pH modifier decreases the levels/effect of atazanavir (source: Drug Bank)
sodium bicarbonate This gastric pH modifier decreases the levels/effect of atazanavir (source: Drug Bank)
sunitinib Possible increase in sunitinib levels (source: Drug Bank)
sunitinib Possible increase in sunitinib levels (source: Drug Bank)
tacrolimus Increases the effect and toxicity of immunosuppressant (source: Drug Bank)
tacrolimus Increases the effect and toxicity of immunosuppressant (source: Drug Bank)
tenofovir Tenofovir decreases the levels/effects of atazanavir (source: Drug Bank)
tenofovir Tenofovir decreases the levels/effects of atazanavir (source: Drug Bank)
triazolam Increases the effect and toxicity of benzodiazepine (source: Drug Bank)
triazolam Increases the effect and toxicity of benzodiazepine (source: Drug Bank)
trimipramine Increases the effect and toxicity of tricyclics (source: Drug Bank)
trimipramine Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, trimipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of trimipramine if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
warfarin The protease inhibitor increases the anticoagulant effect (source: Drug Bank)
warfarin The protease inhibitor, atazanavir, may increase the anticoagulant effect of warfarin. (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of the statin (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of the statin (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of bepridil (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of bepridil (source: Drug Bank)
atazanavir Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if atazanavir is initiated, discontinued or dose changed. Dosage adjustments may be required. (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank)
atazanavir Increased risk of cardiotoxicity and arrhythmias (source: Drug Bank)
atazanavir Atazanavir increases levels of clarithromycin (source: Drug Bank)
atazanavir Atazanavir increases levels of clarithromycin (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of tricyclics (source: Drug Bank)
atazanavir Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, clomipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of clomipramine if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of immunosuppressant (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of immunosuppressant (source: Drug Bank)
atazanavir Atazanavir may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of tricyclics (source: Drug Bank)
atazanavir Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, desipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of desipramine if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of ergot derivative (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of ergot derivative (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of diltiazem (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of diltiazem (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of tricyclics (source: Drug Bank)
atazanavir Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, doxepin, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of doxepin if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Efavirenz decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir Efavirenz decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of ergot derivative (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of ergot derivative (source: Drug Bank)
atazanavir This CYP3A4 inhibitor increases levels/toxicity of erlotinib (source: Drug Bank)
atazanavir This CYP3A4 inhibitor increases levels/toxicity of erlotinib (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of tricyclics (source: Drug Bank)
atazanavir Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, imipramine, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of imipramine if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Increased risk of hyperbilirubinemia with this association (source: Drug Bank)
atazanavir Increased risk of hyperbilirubinemia with this association (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir Increased risk of myopathy/rhabdomyolysis (source: Drug Bank)
atazanavir Increased risk of myopathy/rhabdomyolysis (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of benzodiazepine (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of benzodiazepine (source: Drug Bank)
atazanavir Decreases levels/effect of atazanavir (source: Drug Bank)
atazanavir Decreases levels/effect of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of tricyclics (source: Drug Bank)
atazanavir Atazanavir may increase the effect and toxicity of the tricyclic antidepressant, nortriptyline, by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of nortriptyline if atazanavir if initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir The protease inhibitor increases the effect and toxicity of pimozide (source: Drug Bank)
atazanavir The protease inhibitor, atazanavir, may increase the effect and toxicity of pimozide. (source: Drug Bank)
atazanavir Increased risk of cardiotoxicity/arrhythmias (source: Drug Bank)
atazanavir Increased risk of cardiotoxicity/arrhythmias (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir Atazanavir increases levels/toxicity of ramelteon (source: Drug Bank)
atazanavir Atazanavir increases levels/toxicity of ramelteon (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanaivr (source: Drug Bank)
atazanavir This gastric pH modifier decreases the levels/effects of atazanaivr (source: Drug Bank)
atazanavir Increased levels of ranolazine - risk of toxicity (source: Drug Bank)
atazanavir Atazanavir increases levels/toxicity of rifabutin (source: Drug Bank)
atazanavir Atazanavir increases levels/toxicity of rifabutin (source: Drug Bank)
atazanavir Rifampin reduces levels and efficacy of atazanavir (source: Drug Bank)
atazanavir Rifampin reduces levels and efficacy of atazanavir (source: Drug Bank)
atazanavir The protease inhibitor, Atazanavir, may increase the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Atazanavir therapy is initiated, discontinued or altered. (source: Drug Bank)
atazanavir Atazanavir may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity. (source: Drug Bank)
atazanavir Atazanavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen. (source: Drug Bank)
atazanavir Atazanavir may increase the serum concentration of Tamoxifen by decreasing its metabolism. Monitor for increased adverse/toxic effects of Tamoxifen. (source: Drug Bank)
atazanavir Atazanvir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Atazanavir is initiated, discontinued, or dose changed. (source: Drug Bank)
atazanavir Atazanvir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Atazanavir is initiated, discontinued, or dose changed. (source: Drug Bank)
atazanavir Co-administration may result in altered plasma concentrations of Atazanavir and/or Telithromycin. Consider alternate therapy or monitor the therapeutic/adverse effects of both agents. (source: Drug Bank)
atazanavir Atazanavir may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided. (source: Drug Bank)
atazanavir The strong CYP3A4 inhibitor, Atazanavir, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Tenofovir decreases the levels/effects of atazanavir (source: Drug Bank)
atazanavir Concomitant therapy may result in decreased serum levels of Atazanavir and increased levels of Tenofovir. Concomitant therapy should only be used with the inclusion of Ritonavir. (source: Drug Bank)
atazanavir The strong CYP3A4 inhibitor, Atazanavir, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Tipranavir, co-administered with Ritonavir, may decrease the plasma concentration of Atazanavir. Consider alternate therapy. (source: Drug Bank)
atazanavir Atazanavir may decrease the metabolism and clearance of Tolterodine. Adjust the Tolterodine dose and monitor for efficacy and toxicity. (source: Drug Bank)
atazanavir Atazanavir may decrease the metabolism and clearance of Tolterodine. Adjust the Tolterodine dose and monitor for efficacy and toxicity. (source: Drug Bank)
atazanavir Atazanavir may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. (source: Drug Bank)
atazanavir The protease inhibitor, Atazanavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir The protease inhibitor, Atazanavir, may increase the efficacy/toxicity of Trazodone by inhibiting Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir The strong CYP2C8 inhibitor, Atazanavir, may decrease the metabolism and clearance of oral Tretinoin. Consider alternate therapy or monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Atazanavir is initiated, discontinued to dose changed. (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of benzodiazepine (source: Drug Bank)
atazanavir Atazanavir increases the effect and toxicity of benzodiazepine (source: Drug Bank)
atazanavir The strong CYP3A4 inhibitor, Atazanavir, may decrease the metabolism and clearance of Trimipramine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Atazanavir, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil. (source: Drug Bank)
atazanavir Atazanavir, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Atazanavir is initiated, discontinued, or dose changed. (source: Drug Bank)
atazanavir Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Atazanavir, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of atazanavir by decreasing its metabolism. The serum concentration of voriconazole may be increased by atazanavir. Monitor for changes in the therapeutic and adverse effects of both agents if concomitant therapy is initiated, discontinued or if doses are changed. (source: Drug Bank)
atazanavir Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)
atazanavir Atazanavir, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if atazanavir is initiated, discontinued or dose changed. (source: Drug Bank)

Curated Information ?

Publications related to atazanavir: 17

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
PharmGKB summary: very important pharmacogene information for UGT1A1. Pharmacogenetics and genomics. 2014. Barbarino Julia M, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genomewide association study of atazanavir pharmacokinetics and hyperbilirubinemia in AIDS Clinical Trials Group protocol A5202. Pharmacogenetics and genomics. 2014. Johnson Daniel H, et al. PubMed
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Effect of Adherence as Measured by MEMS, Ritonavir Boosting, and CYP3A5 Genotype on Atazanavir Pharmacokinetics in Treatment-Naive HIV-Infected Patients. Clinical pharmacology and therapeutics. 2012. Savic R M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Short communication: UGT1A1*28 variant allele is a predictor of severe hyperbilirubinemia in HIV-infected patients on HAART in southern Brazil. AIDS research and human retroviruses. 2012. Turatti Lisiane, et al. PubMed
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The Dual Role of Pharmacogenetics in HIV Treatment: Mutations and Polymorphisms Regulating Antiretroviral Drug Resistance and Disposition. Pharmacological reviews. 2012. Michaud Veronique, et al. PubMed
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Population Pharmacokinetic modelling of the association between 63396C->T Pregnane-X-Receptor (PXR) polymorphism and unboosted atazanavir clearance. Antimicrobial agents and chemotherapy. 2010. Schipani Alessandro, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Genetic factors influencing severe atazanavir-associated hyperbilirubinemia in a population with low UDP-glucuronosyltransferase 1A1*28 allele frequency. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2010. Park Wan Beom, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Prediction of adverse drug reactions using decision tree modeling. Clinical pharmacology and therapeutics. 2010. Hammann F, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of Gilbert's syndrome. Pharmacogenomics. 2008. Strassburg Christian P. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Diagnosis and management of HIV drug hypersensitivity. The Journal of allergy and clinical immunology. 2008. Davis Carla M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Multidrug resistance 1 polymorphisms and trough concentrations of atazanavir and lopinavir in patients with HIV. Pharmacogenomics. 2007. Ma Qing, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype. Hepatology (Baltimore, Md.). 2006. Lankisch Tim O, et al. PubMed
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Relationship between hyperbilirubinaemia and UDP-glucuronosyltransferase 1A1 (UGT1A1) polymorphism in adult HIV-infected Thai patients treated with indinavir. Pharmacogenetics and genomics. 2006. Boyd Mark A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Plasma levels of atazanavir and the risk of hyperbilirubinemia are predicted by the 3435C-->T polymorphism at the multidrug resistance gene 1. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2006. Rodríguez Nóvoa Sonia, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Overview of the pharmacogenetics of HIV therapy. The pharmacogenomics journal. 2006. Rodríguez-Nóvoa S, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation. Drug metabolism and disposition: the biological fate of chemicals. 2005. Zhang Donglu, et al. PubMed
Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia. The Journal of infectious diseases. 2005. Rotger Margalida, et al. PubMed

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB01072
ChEBI:
37924
KEGG Drug:
D01276
PubChem Compound:
148192
PubChem Substance:
46508504
725881
Drugs Product Database (DPD):
2248610
BindingDB:
13934
ChemSpider:
130642
Therapeutic Targets Database:
DNC000332

Clinical Trials

These are trials that mention atazanavir and are related to either pharmacogenetics or pharmacogenomics.

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Sources for PharmGKB drug information: DrugBank, Open Eye Scientific Software.