PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit

Overview

Alternate Names: calcium channel, L type, alpha-1 polypeptide, isoform 2; calcium channel, neuroendocrine/brain-type, alpha 1 subunit; voltage-gated calcium channel alpha 1 subunit; voltage-gated calcium channel alpha subunit Cav1.3
Alternate Symbols: CACH3; CACN4; CACNL1A2; CCHL1A2; Cav1.3
PharmGKB Accession Id: PA84

Details

Cytogenetic Location: chr3 : p21.1
GP mRNA Boundary†: chr3 : 53504116 - 53821001
GP Gene Boundary†: chr3 : 53494116 - 53824001
Strand: plus
Product Name: calcium channel, L type, alpha-1 polypeptide, isoform 2, calcium channel, neuroendocrine/brain-type, alpha 1 subunit, calcium channel, voltage-dependent, L type, alpha 1D subunit, voltage-gated calcium channel alpha 1 subunit, voltage-gated calcium channel alpha subunit Cav1.3
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
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  • PD
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Pathways
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
amiodarone
  •   
  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
arsenic trioxide
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  • PD
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  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
chlorpropamide
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  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
cisapride
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  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
disopyramide
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
dofetilide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
droperidol
  •   
  • PD
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  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
flecainide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
gliclazide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
glimepiride
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
glipizide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
halofantrine
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
haloperidol
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
ibutilide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
lidocaine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mesoridazine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
methadone
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mexiletine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
nateglinide
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
nicotine
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
pentamidine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pimozide
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
procainamide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
propafenone
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
quinidine
  •   
  • PD
  •   
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
repaglinide
  •   
  • PD
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  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
sotalol
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
sparfloxacin
  •   
  • PD
  •   
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  •   
Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
thioridazine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
tocainide
  •   
  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
tolbutamide
  •   
  • PD
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  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Diabetes Mellitus
  •   
  • PD
  •   
  •   
  •   
Pathways

Downloads

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LinkOuts

Entrez Gene ID:
776
OMIM Accession:
114206
UCSC Genome Browser ID:
NM_000720
Ref Seq NM Accession:
NM_000720
NM_001128839
NM_001128840
Ref Seq NP Accession:
AAA35629
AAA58402
AAD08651
ABY66526
BAA07804
BAD92408
BAG57776
BAH11755
EAW65286
EAW65287
EAW65288
EAW65289
EAW65290
EAW65291
EAW65292
EAW65293
EAW65294
EAW65295
NP_000711
NP_001122311
NP_001122312
Q01668
Q59GD8
Q71UT1
Q9UDC3
Ref Seq NT Accession:
AC_000046
AC_000135
NC_000003
NT_022517
NW_001838877
NW_921651
UniProtKB Accesssion:
CAC1D_HUMAN (Q01668)
Ensembl ID:
ENSG00000157388
GenAtlas ID:
CACNA1D
GeneCard ID:
CACNA1D
SOURCE ID:
CACNA1D
MutDB ID:
CACNA1D
PromoLign ID:
ortho_1481
ALFRED ID:
LO003263O
HuGE ID:
CACNA1D
Comparative Toxicogenomics Acc ID:
776
ModBase:
Q01668

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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