PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
ATP7B
ATPase, Cu++ transporting, beta polypeptide

Overview

Alternate Names: ATPase, Cu(2+)- transporting, beta polypeptide; ATPase, Cu++ transporting, beta polypeptide (Wilson disease); OTTHUMP00000040880; Wilson disease-associated protein; copper pump 2; copper-transporting ATPase 2
Alternate Symbols: PWD; WC1; WD; WND
PharmGKB Accession Id: PA73

Details

Cytogenetic Location: chr13 : q14.3
GP mRNA Boundary†: chr13 : 51404806 - 51483631
GP Gene Boundary†: chr13 : 51401806 - 51493631
Strand: minus
Product Name: ATPase, Cu(2+)- transporting, beta polypeptide, ATPase, Cu++ transporting, beta polypeptide, ATPase, Cu++ transporting, beta polypeptide (Wilson disease), ATPase, Cu++ transporting, beta polypeptide isoform a, ATPase, Cu++ transporting, beta polypeptide isoform b, OTTHUMP00000040880, WD protein, Wilson disease-associated protein, copper pump 2, copper-transporting ATPase 2
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antineoplastic agents
  •   
  • PD
  • PK
  •   
  •   
Pathways
  Drug Relationship Evidence
Phenotype data available No genotype data Literature annotations available Not annotated
cisplatin
  •   
  • PD
  • PK
  • FA
  • GN
Publications, Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
docetaxel
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
gemcitabine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
oxaliplatin
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
paclitaxel
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
platinum
  •   
  • PD
  • PK
  •   
  • GN
Publications, Pathways

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Breast Neoplasms
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Carcinoma, Non-Small-Cell Lung
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Colorectal Neoplasms
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Lung Neoplasms
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Melanoma
  •   
  • PD
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Neoplasms
  •   
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Ovarian Neoplasms
  •   
  • PD
  • PK
  •   
  •   
Pathways
The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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