Overview
| Alternate Names: | ANTHRACYCLINE RESISTANCE-ASSOCIATED PROTEIN; ARA; ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 6; ABCC6; ATP-binding cassette, sub-family C, member 6; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 6; MRP6; anthracycline resistance-associated; anthracycline resistance-associated protein; pseudoxanthoma elasticum |
|---|---|
| Alternate Symbols: | ABC34; AF076622.1; ARA; EST349056; MLP1; MOATE; MRP6; PXE; PXE1 |
| PharmGKB Accession Id: | PA58 |
Details
| Cytogenetic Location: | chr16 : p13.11 |
|---|---|
| GP mRNA Boundary†: | chr16 : 16151491 - 16224815 |
| GP Gene Boundary†: | chr16 : 16148491 - 16234815 |
| Strand: | minus |
| Product Name: | ATP-binding cassette, sub-family C, member 6, anthracycline resistance-associated, pseudoxanthoma elasticum |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
Curated Annotations (
)
-
rs2238472
at chr16:16159100
in
ABCC6
Risk or phenotype-associated allele: G Phenotype: The ABCC6 rs2238472 G variant was associated with toxicity in response to docetaxel and thalidomide. Study size: 47 Study population/ethnicity: Patients diagnosed with castration-resistant prostate cancer enrolled in a randomized phase II clinical trial comparing docetaxel to docetaxel with thalidomide. Significance metric(s): p = 0.006 Type of association: CO; TOX- Variant Name:
- ABCC6:rs2238472 A>G; NM_001171.5:c.3803G>A; NP_001162.4:p.Arg1268Gln
- Related Drugs:
- docetaxel, thalidomide
- Related Diseases:
- Prostatic Neoplasms
- Evidence:
-
PMID:20038957
Variant names are different names that have been used in the literature and other resources to
refer to the same variant.
Non-Curated Information
A list of non-curated publications that mention this gene along with other genes is available.
PharmGKB Curated Pathways
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
cytarabine |
|
Publications |
|
|
daunorubicin |
|
Publications |
|
|
dimethyl sulfoxide |
|
Pathways |
|
|
docetaxel |
|
Publications, Variants |
|
|
doxorubicin |
|
Publications, Pathways |
|
|
etoposide |
|
Publications |
|
|
imatinib |
|
Publications |
|
|
mitoxantrone |
|
Publications |
|
|
thalidomide |
|
Publications, Variants |
|
|
vincristine |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this gene.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Breast Neoplasms |
|
Pathways |
|
|
Cardiomyopathy, Dilated |
|
Pathways |
|
|
Cardiomyopathy, Hypertrophic |
|
Pathways |
|
|
Cardiomyopathy, Restrictive |
|
Pathways |
|
|
Chagas Cardiomyopathy |
|
Pathways |
|
|
Leukemia, Myeloid, Acute |
|
Publications |
|
|
Lung Neoplasms |
|
Pathways |
|
|
Neoplasms |
|
Publications, Pathways |
|
|
Precursor Cell Lymphoblastic Leukemia-Lymphoma |
|
Pathways |
|
|
Prostatic Neoplasms |
|
Publications, Variants |
|
|
Pseudoxanthoma Elasticum |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other diseases is available.
Downloads
You must sign in before you can download data.
LinkOuts
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.