- Overview
- Properties
- Genetics
- Related Genes
- Pathways
- Related Drugs
- Related Diseases
- Datasets
- Downloads/LinkOuts
Overview
| Generic Names: | Dehydrocortisone; PRD; Prednisona [INN-Spanish]; Prednisonum [INN-Latin] |
|---|---|
| Trade Names: | Adasone; Ancortone; Apo-prednisone; Betapar; Bicortone; Cartancyl; Colisone; Cortan; Cortancyl; Cortidelt; Cotone; Dacorten; Dacortin; Decortancyl; Decortin; Decortisyl; Dekortin; Delcortin; Dellacort; Dellacort A; Delta Cortelan; Delta E; Delta-cortelan; Delta-cortisone; Delta-cortone; Delta-dome; Deltacortene; Deltacortisone; Deltacortone; Deltasone; Deltison; Deltisona; Deltisone; Deltra; Di-Adreson; Diadreson; Econosone; Encorton; Encortone; Enkorton; Fernisone; Fiasone; Hostacortin; In-Sone; Incocortyl; Juvason; Lisacort; Me-Korti; Metacortandracin; Meticorten; Nisona; Nizon; Novoprednisone; Nurison; Orasone; Origen Prednisone; Panafcort; Panasol; Paracort; Parmenison; Pehacort; Precort; Predeltin; Prednicen-M; Prednicorm; Prednicort; Prednicot; Prednidib; Prednilonga; Prednison; Prednisone Intensol; Prednitone; Prednizon; Prednovister; Presone; Pronison; Rectodelt; Retrocortine; Servisone; Sone; Sterapred; Supercortil; Ultracorten; Ultracortene; Winpred; Wojtab; Zenadrid |
| Brand Mixtures: | Cortab (Biotin + Chlorpheniramine Maleate + D-Pantothenic Acid + Inositol + Nicotinic Acid + Prednisone + Pyridoxine Hydrochloride + Thiamine Mononitrate + Vitamin a + Vitamin B2 + Vitamin D + Vitamin E (Dl-Alpha Tocopheryl Acetate)); Metreton Tab (Chlorpheniramine Maleate + Prednisone + Vitamin C); Predniderm Tab (Inositol + Pheniramine Maleate + Phosphatidyl Choline + Prednisone + Vitamin a + Vitamin D2 + Vitamin E); Sterolin Liq (Biotin + Fatty Acids Unsaturated + Inositol + Nicotinic Acid + Pheniramine Maleate + Phosphatidyl Choline + Prednisone + Vitamin a Palmitate + Vitamin B2 + Vitamin D2 + Vitamin E) |
| PharmGKB Accession Id: | PA451100 |
Description
A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver. PubChem (source: Drug Bank)
Indication
For the treatment of drug-induced allergic reactions, perennial or seasonal allergic rhinitis, serum sickness, giant cell arteritis acute rheumatic or nonrheumatic carditis, systemic dermatomyositis, systemic lupus erythematosus, atopic dermatitis, contact dermatitis, exfoliative dermatitis, bullous dermatitis herpetiformis, severe seborrheic dermatitis, severe (Stevens-Johnson syndrome) erythema multiforme, mycosis fungoides, pemphigus, severe psoriasis, acute adrenocortical insufficiency, Addison's disease, secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with neoplasms, nonsuppurative thyroiditis, ulceratice colitis, Crohn's disease, acquired hemolytic anemia, congenital hypoplastic anemia, erythroblastopenia, adult secondary thrombocytopenia, adult idiopathic thrombocytopenia purpura, acute or subacute bursitis, epicondylitis, acute nonspecific tenosynovitis, acute or chronic lymphocytic leukemia, Hodgkin's or non-Hodgkin's lynphomas, Waldenstrom's macroglobulinemia, primary brain tumors (adjunct), nephrotic syndrome, tuberculous meningitis, multiple sclerosis, myasthenia gravis. cerebral edema, chorioretinitis, diffuse posterior choroiditis, aleergic conjunctivitis, Herpes zoster ophthalmicus, anterior segment inflammation, iridocyclitis, iritis, keratitis, optoc neuritis, sympathetic ophthalmia, corneal marginal allergic ulcers, symptomatic sarcoidosis, Loeffler's syndrome not manageable by other means, berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy and aspiration pneumonitis. (source: Drug Bank)
ATC Therapeutic Categories
- A07EA:Corticosteroids acting locally
- H02AB:Glucocorticoids
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
Prednisone is a glucocorticoid agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. (source: Drug Bank)
Pharmacology
Prednisone, the most commonly-prescribed corticosteroid, is used to treat allograft rejection, asthma, systemic lupus erythematosus, and many other inflammatory states. Prednisone has very little mineralocorticoid activity. (source: Drug Bank)
Food Interactions
Avoid alcohol.
Avoid taking with grapefruit juice.
Take with food to reduce irritation.
(source:
Drug Bank)
Absorption, Distribution, Metabolism, Elimination & Toxicity
Biotransformation
Hepatic. (source: Drug Bank)
Protein Binding
Extensively bound to plasma proteins. (source: Drug Bank)
Absorption
Readily absorbed from the gastrointestinal tract. (source: Drug Bank)
Isomeric SMILES Code:
C[C@]12CC(=O)[C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C (source: Drug Bank)
In-Depth Annotations (
)
-
rs1045642
at chr7:86976581
in
ABCB1
Risk or phenotype-associated allele: CC genotype. Phenotype: Increased time to wean from steroid treatment in pediatric heart transplantation. Study size: 69. Study population/ethnicity: Pediatric heart transplant patients from the Children's Hospital of Pittsburgh, Pennsylvania, USA. Significance metric(s): p = 0.04. Type of association: GN; PD.- Variant Name:
- ABCB1:3435T>C, Ile1145Ile
- Related Drugs:
- prednisone
- Related Diseases:
- Drug Resistance, Organ Transplantation
- Evidence:
-
PMID:12175731
http://www.pharmgkb.org/.../variant.jsp#ImportantVariantInformationforABCB1-3435
The following genes are in curated knowledge about this drug.
| Gene | Relationship | Evidence | |
|---|---|---|---|
|
|
ABCB1 |
|
Publications, Variants |
|
|
CYP3A4 |
|
Publications |
|
|
CYP3A5 |
|
Publications |
|
|
GSTM1 |
|
Publications |
|
|
GSTP1 |
|
Publications |
|
|
GSTT1 |
|
Publications |
|
|
HSD11B1 |
|
Publications |
|
|
IL10 |
|
Publications |
|
|
MSH6 |
|
Publications |
|
|
MTHFR |
|
Publications |
|
|
NR3C1 |
|
Publications |
|
|
SAA1 |
|
Publications |
|
|
SLC19A1 |
|
Publications |
|
|
TPMT |
|
Publications |
|
|
TYMS |
|
Publications |
|
|
UGT1A1 |
|
Publications |
|
|
VDR |
|
Publications |
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| ANXA1 |
|
(source: Drug Bank) |
| NR3C1 |
|
(source: Drug Bank) |
PharmGKB Curated Pathways
- Glucocorticoid and Inflammatory genes Pathway (PD)
- Glucocorticoid and Inflammatory genes Pathway (Regulation)
BioCarta Pathways†
- chromatin remodeling by hswi/snf atp-dependent complexes - (BioCarta via Pathway Interaction Database)
- corticosteroids and cardioprotection - (BioCarta via Pathway Interaction Database)
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| acenocoumarol |
|
The corticosteroid alters the anticoagulant effect (source: Drug Bank) |
| amobarbital |
|
The barbiturate decreases the effect of the corticosteroid (source: Drug Bank) |
| aspirin |
|
The corticosteroid decreases the effect of salicylates (source: Drug Bank) |
| butalbital |
|
The barbiturate decreases the effect of the corticosteroid (source: Drug Bank) |
| clomifene |
|
The estrogenic agent increases the effect of corticosteroid (source: Drug Bank) |
| dicumarol |
|
The corticosteroid alters the anticoagulant effect (source: Drug Bank) |
| diethylstilbestrol |
|
The estrogenic agent increases the effect of corticosteroid (source: Drug Bank) |
| edrophonium |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
| estradiol |
|
The estrogenic agent increases the effect of corticosteroid (source: Drug Bank) |
| estrone |
|
The estrogenic agent increases the effect of corticosteroid (source: Drug Bank) |
| ethinyl estradiol |
|
The estrogenic agent increases the effect of corticosteroid (source: Drug Bank) |
| hexobarbital |
|
The barbiturate decreases the effect of the corticosteroid (source: Drug Bank) |
| itraconazole |
|
The imidazole increases the effect and toxicity of the corticosteroid (source: Drug Bank) |
| ketoconazole |
|
The imidazole increases the effect and toxicity of the corticosteroid (source: Drug Bank) |
| mephenytoin |
|
The enzyme inducer decreases the effect of the corticosteroid (source: Drug Bank) |
| mestranol |
|
The estrogenic agent increases the effect of corticosteroid (source: Drug Bank) |
| methylphenobarbital |
|
The barbiturate decreases the effect of the corticosteroid (source: Drug Bank) |
| neostigmine |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
| pentobarbital |
|
The barbiturate decreases the effect of the corticosteroid (source: Drug Bank) |
| phenobarbital |
|
The barbiturate decreases the effect of the corticosteroid (source: Drug Bank) |
| phenytoin |
|
The enzyme inducer decreases the effect of the corticosteroid (source: Drug Bank) |
| primidone |
|
The barbiturate decreases the effect of the corticosteroid (source: Drug Bank) |
| pyridostigmine |
|
The corticosteroid decreases the effect of anticholinesterases (source: Drug Bank) |
| rifampin |
|
The enzyme inducer decreases the effect of the corticosteroid (source: Drug Bank) |
| salicylate-magnesium |
|
The corticosteroid decreases the effect of salicylates (source: Drug Bank) |
| salicylate-sodium |
|
The corticosteroid decreases the effect of salicylates (source: Drug Bank) |
| warfarin |
|
The corticosteroid alters the anticoagulant effect (source: Drug Bank) |
Curated Information
The following diseases are in curated knowledge about this drug.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Arthritis, Rheumatoid |
|
Publications |
|
|
Crohn Disease |
|
Publications |
|
|
Nephrotic Syndrome |
|
Publications |
|
|
Precursor Cell Lymphoblastic Leukemia-Lymphoma |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Curated Phenotype Datasets
These datasets are sorted alphabetically by title.
- Pharmacogenetic Risk Factors for Osteonecrosis of the Hip Among Children With Leukemia




- CO
Submitted by Mary Relling, PharmD involving ABCB1, CYP3A4, CYP3A5, GSTM1, GSTP1, GSTT1, MTHFR, NR3C1, SLC19A1, TPMT, TYMS, UGT1A1, VDR, dexamethasone, methotrexate, prednisone, , Osteonecrosis and Precursor Cell Lymphoblastic Leukemia-Lymphoma - Tacrolimus dosing and Steroid Weaning in pediatric heart transplant patients




- CO
- PK
Submitted by Burckart GJ involving ABCB1, CYP3A4, CYP3A5, glucocorticoids, prednisone, tacrolimus, and Organ Transplantation
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
- Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia
- Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia
- Osteonecrosis in Children with Acute Lymphoblastic Leukemia: A Report from the Children's Oncology Group
- Pharmacogenetics of Minimal Residual Disease Response in Children with B-Precursor Acute Lymphoblastic Leukemia (ALL): A Report from the Children's Oncology Group
- Physicochemical determinants of human renal clearance
- The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
Downloads
You must sign in before you can download data.
LinkOuts
Common Searches
Search PubMed
Search Medline Plus
Search PubChem
Search CTD
Non-Curated Publications
A list of non-curated publications that mention this drug is available.
