Drug/Small Molecule:
methoxsalen

2D structure

Overview

Trade Names: Ammodin; Ammoidin; Meladinin; Meladinine; Meladoxen; Meloxine; Methoxa-Dome; Methoxalen; Methoxaten; New-Meladinin; Oxoralen; Oxsoralen; Oxsoralen Lotion; Oxsoralen-Ultra; Oxypsoralen; Proralone-Mop; Psoralen-Mop; Puvalen; Puvamet; Ultra Mop; Ultramop Lotion; Uvadex; Xanthotoxin; Xanthotoxine; Xanthoxin; Zanthotoxin
PharmGKB Accession Id: PA450433

Description

A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. PubChem (source: Drug Bank)

Indication

For the treatment of psoriasis and vitiligo (source: Drug Bank)

ATC Therapeutic Categories

  • D05AD:Psoralens for topical use
  • D05BA:Psoralens for systemic use

Pharmacology, Interactions, and Contraindications

Mechanism Of Action

After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function. (source: Drug Bank)

Pharmacology

Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. (source: Drug Bank)

Food Interactions

Take with food or milk, or in two divided doses 30 minutes apart to decrease nausea. (source: Drug Bank)

Isomeric SMILES Code:

COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2 (source: Drug Bank)

A list of non-curated publications that mention this drug along with other genes is available.

Drug Targets

Gene Description
CYP2A6 Uncurated Annotation (source: Drug Bank)

A list of non-curated publications that mention this drug along with other drugs is available.

Drug Interactions

Drug Description
mephenytoin Uncurated Annotation The hydantoin decreases the effect of psoralene (source: Drug Bank)
phenytoin Uncurated Annotation The hydantoin decreases the effect of psoralene (source: Drug Bank)

Non-Curated Information

A list of non-curated publications that mention this drug along with other diseases is available.

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

LinkOuts

Web Resource:
Wikipedia
DrugBank:
DB00553
ChEBI ID:
18358
KEGG Compound ID:
C01864
KEGG Drug ID:
D00139
PubChem Compound ID:
4114
PubChem Substance ID:
152480

Common Searches

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Non-Curated Publications

A list of non-curated publications that mention this drug is available.

PharmGKB integrates drug information from different sources: DrugBank, Open Eye Scientific Software.
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