Overview
| IUPAC Name: | 9-methoxyfuro[3,2-g]chromen-7-one |
|---|---|
| Trade Names: | Ammodin; Ammoidin; Meladinin; Meladinine; Meladoxen; Meloxine; Methoxa-Dome; Methoxalen; Methoxaten; New-Meladinin; Oxoralen; Oxsoralen; Oxsoralen Lotion; Oxsoralen-Ultra; Oxypsoralen; Proralone-Mop; Psoralen-Mop; Puvalen; Puvamet; Ultra Mop; Ultramop Lotion; Uvadex; Xanthotoxin; Xanthotoxine; Xanthoxin; Zanthotoxin |
| PharmGKB Accession Id: | PA450433 |
Description
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. [PubChem]
Indication
For the treatment of psoriasis and vitiligo
ATC Therapeutic Categories
- D05AD:Psoralens for topical use
- D05BA:Psoralens for systemic use
Pharmacology and Interactions
Mechanism Of Action
After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
Pharmacology
Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Food Interactions
Take with food or milk, or in two divided doses 30 minutes apart to decrease nausea.
Absorption, Distribution, Metabolism, Elimination & Toxicity
Half Life
Approximately 2 hours
Chemical Properties
Chemical Formula:
C12H8O4
SMILES Code:
COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2
(Format: OpenEye Isomeric)
Molecular Weight ( average / monoisotopic )
216.1895 / 216.0423
Non-Curated Information
A list of non-curated publications that mention this drug along with other genes is available.
Metabolizing Enzymes
Drug Targets
Non-Curated Information
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| ethotoin | The hydantoin decreases the effect of psoralene |
| fosphenytoin | The hydantoin decreases the effect of psoralene |
| mephenytoin | The hydantoin decreases the effect of psoralene |
| phenytoin | The hydantoin decreases the effect of psoralene |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.