Overview
| Trade Names: | Ammodin; Ammoidin; Meladinin; Meladinine; Meladoxen; Meloxine; Methoxa-Dome; Methoxalen; Methoxaten; New-Meladinin; Oxoralen; Oxsoralen; Oxsoralen Lotion; Oxsoralen-Ultra; Oxypsoralen; Proralone-Mop; Psoralen-Mop; Puvalen; Puvamet; Ultra Mop; Ultramop Lotion; Uvadex; Xanthotoxin; Xanthotoxine; Xanthoxin; Zanthotoxin |
|---|---|
| PharmGKB Accession Id: | PA450433 |
Description
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. PubChem (source: Drug Bank)
Indication
For the treatment of psoriasis and vitiligo (source: Drug Bank)
ATC Therapeutic Categories
- D05AD:Psoralens for topical use
- D05BA:Psoralens for systemic use
Pharmacology, Interactions, and Contraindications
Mechanism Of Action
After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function. (source: Drug Bank)
Pharmacology
Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. (source: Drug Bank)
Food Interactions
Take with food or milk, or in two divided doses 30 minutes apart to decrease nausea. (source: Drug Bank)
Isomeric SMILES Code:
COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2 (source: Drug Bank)
A list of non-curated publications that mention this drug along with other genes is available.
Drug Targets
| Gene | Description | |
|---|---|---|
| CYP2A6 |
|
(source: Drug Bank) |
A list of non-curated publications that mention this drug along with other drugs is available.
Drug Interactions
| Drug | Description | |
|---|---|---|
| mephenytoin |
|
The hydantoin decreases the effect of psoralene (source: Drug Bank) |
| phenytoin |
|
The hydantoin decreases the effect of psoralene (source: Drug Bank) |
Non-Curated Information
A list of non-curated publications that mention this drug along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
Common Searches
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Non-Curated Publications
A list of non-curated publications that mention this drug is available.