PharmGKB: The Pharmacogenomics Knowledge Base

Disease:
Acquired Immunodeficiency Syndrome

Overview

Alternate Names: AIDS; AIDS, NOS; Acquired Immune Deficiency Syndrome; Acquired Immuno Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immuno-Deficiency Syndromes; Acquired Immunodeficiency Syndromes; Acquired human immunodeficiency virus infection syndrome NOS; Immuno-Deficiency Syndrome, Acquired; Immuno-Deficiency Syndromes, Acquired; Immunodeficiency Syndrome, Acquired; Immunodeficiency Syndromes, Acquired; Immunologic Deficiency Syndrome, Acquired; Syndrome, Acquired Immuno-Deficiency; Syndrome, Acquired Immunodeficiency; Syndromes, Acquired Immuno-Deficiency; Syndromes, Acquired Immunodeficiency
PharmGKB Accession Id: PA443250
External Vocabularies
  • MeSH: D000163 - Acquired Immunodeficiency Syndrome
  • SnoMed Clinical Terminology: 186715004 - Acquired human immunodeficiency virus infection syndrome NOS
  • SnoMed Clinical Terminology: 62479008 - Acquired immune deficiency syndrome
  • Unified Medical Language System: C0001175 - C0001175

Curated Annotations (Curated Annotation)

  1. rs2814778 at chr1:157441307 in CADM3, DARC
    African-American individuals with the C/C genotype of this promoter SNP are 40% more likely to acquire HIV-1 than T/T or T/C individuals. However, once infected, those with the C/C genotype exhibited slower disease progression.
    Variant Name:
    DARC: T-46C
    Related Diseases:
    Acquired Immunodeficiency Syndrome
    Evidence:
    PMID:18621010

Non-Curated Annotations (Non-Curated Annotation)

  1. rs8321 at chr6:30140501 in PPP1R11, ZNRD1
    GWAS results: Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02).. (Initial Sample Size: 275 HIV positive patients, 1,438 controls; Replication Sample Size: 626 patients); (Region: 6p21.33; Reported Gene(s): ZNRD1, RNF39; Risk Allele: rs8321-G); (p-value= 0.0000005).This variant is associated with AIDS progression.
    Related Diseases:
    Acquired Immunodeficiency Syndrome
    Evidence:
    PMID:19115949
    http://www.genome.gov/gwastudies/
  2. rs10484554 at chr6:31382534
    GWAS results: Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02).. (Initial Sample Size: 275 HIV positive patients, 1,438 controls; Replication Sample Size: 626 patients); (Region: 6p21.33; Reported Gene(s): HLA-C; Risk Allele: rs10484554-T); (p-value= 0.00000006).This variant is associated with AIDS progression.
    Related Diseases:
    Acquired Immunodeficiency Syndrome
    Evidence:
    PMID:19115949
    http://www.genome.gov/gwastudies/
  3. rs2395029 at chr6:31539759 in HCP5
    GWAS results: Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02).. (Initial Sample Size: 275 HIV positive patients, 1,438 controls; Replication Sample Size: 626 patients); (Region: 6p21.33; Reported Gene(s): HCP5, MICB, MCCD1, BAT1, LTB, TNF; Risk Allele: rs2395029-G); (p-value= 3E-19).This variant is associated with AIDS progression.
    Related Diseases:
    Acquired Immunodeficiency Syndrome
    Evidence:
    PMID:19115949
    http://www.genome.gov/gwastudies/
Variant names are different names that have been used in the literature and other resources to refer to the same variant. Non-curated variant information is accumulated solely by computational methods and has not been verified by the scientific staff at PharmGKB.

Curated Information

The following genes are in curated knowledge about this disease.

  Gene Relationship Evidence
No phenotype data No genotype data No literature annotations Not annotated
CADM3
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  •   
Variants
No phenotype data No genotype data Literature annotations available Not annotated
CCL3L1
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
CCR5
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
DARC
  •   
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
IL2
  • CO
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
IL21
  • CO
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
KIAA1109
  • CO
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
MMP9
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
NR2F2
  •   
  • PD
  •   
  • FA
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
NR3C1
  •   
  • PD
  •   
  • FA
  • GN
Publications

Non-Curated Information

A list of non-curated publications that mention this disease along with other genes is available.

Curated Information

The following drugs are in curated knowledge about this disease.

  Drug Class Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
glucocorticoids
  •   
  • PD
  •   
  • FA
  • GN
Publications

Non-Curated Information

A list of non-curated publications that mention this disease along with other drugs is available.

Non-Curated Information

A list of non-curated publications that mention this disease along with other diseases is available.

Common Searches

Search Medline Plus
Search CTD

Non-Curated Publications

A list of non-curated publications that mention this disease is available.

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