PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5

Overview

Alternate Names: ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 5; ABCC5; ATP-binding cassette, sub-family C, member 5; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5; MRP5; canalicular multispecific organic anion transporter C
Alternate Symbols: ABC33; ABCC5; AF104942.1; DKFZp686C1782; EST277145; MOAT-C; MOATC; MRP5; SMRP; pABC11
PharmGKB Accession Id: PA395

Details

Cytogenetic Location: chr3 : q27.1
GP mRNA Boundary†: chr3 : 185120416 - 185218421
GP Gene Boundary†: chr3 : 185117416 - 185228421
Strand: minus
Product Name: ABCC5 variant 2, ABCC5 variant 3, ABCC5 variant 4, ATP-binding cassette, sub-family C, member 5, ATP-binding cassette, sub-family C, member 5 isoform 1, ATP-binding cassette, sub-family C, member 5 isoform 2, canalicular multispecific organic anion transporter C
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antineoplastic agents
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
nucleosides and nucleotides excl. reverse transcriptase inhibitors
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
xenobiotics
  •   
  •   
  •   
  • FA
  •   
Publications
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
azathioprine
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
capecitabine
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
cisplatin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data No literature annotations Not annotated
dimethyl sulfoxide
  •   
  • PD
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
docetaxel
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
doxorubicin
  •   
  • PD
  • PK
  •   
  •   
Publications, Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
fluorouracil
  •   
  •   
  • PK
  • FA
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
folic acid
  •   
  • PD
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
gemcitabine
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
irinotecan
  •   
  • PD
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
mercaptopurine
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
sildenafil
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
tegafur
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
thioguanine
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Adenocarcinoma
  •   
  • PD
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Brain Neoplasms
  •   
  • PD
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Breast Neoplasms
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Carcinoma, Basal Cell
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Carcinoma, Non-Small-Cell Lung
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Cardiomyopathy, Dilated
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Cardiomyopathy, Hypertrophic
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
Cardiomyopathy, Restrictive
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
Chagas Cardiomyopathy
  •   
  • PD
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Colonic Neoplasms
  •   
  • PD
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Colorectal Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
Gallbladder Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Gastrointestinal Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Head and Neck Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Heart Failure
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Inflammatory Bowel Diseases
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Liver Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Lung Neoplasms
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Lymphoma
  •   
  • PD
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Melanoma
  •   
  • PD
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Neoplasms
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Ovarian Neoplasms
  •   
  • PD
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Pancreatic Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Precursor Cell Lymphoblastic Leukemia-Lymphoma
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Prostatic Neoplasms
  •   
  • PD
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Stomach Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Curated Phenotype Datasets

These datasets are sorted alphabetically by title.

  1. Protein expression of genes in the irinotecan pathway
    • Genotype data available
    • Phenotype data available
    • No literature annotations
    • Not annotated
    • FA
    Submitted by Howard McLeod, PharmD involving ABCB1, ABCC1, ABCC2, ABCC3, ABCC5, ABCG2, CES2, CYP3A4, CYP3A5, TOP1, UGT1A1, irinotecan, and Neoplasms

Downloads

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LinkOuts

Entrez Gene ID:
10057
OMIM Accession:
605251
UCSC Genome Browser ID:
NM_005688
Ref Seq NM Accession:
NM_001023587
NM_005688
Ref Seq NP Accession:
AAB71758
AAD04169
AAD37716
AAH50744
AAI40772
AAI42671
AAI42720
AAO49801
AAW82948
AAW82949
AAW82950
BAA22887
BAA76608
BAD92340
BAD92691
EAW78306
EAW78307
EAW78308
EAW78309
EAW78310
NP_001018881
NP_005679
O15440
Q29ZA9
Q29ZB1
Q59FK6
Q59GK6
Q86UX3
Q86W30
Ref Seq NT Accession:
AC_000046
AC_000135
NC_000003
NT_005612
NW_001838884
NW_921807
UniProtKB Accesssion:
MRP5_HUMAN (O15440)
Ensembl ID:
ENSG00000114770
GenAtlas ID:
ABCC5
GeneCard ID:
ABCC5
SOURCE ID:
ABCC5
MutDB ID:
ABCC5
PromoLign ID:
ortho_1429
ALFRED ID:
LO010837T
HuGE ID:
ABCC5
Comparative Toxicogenomics Acc ID:
10057
ModBase:
O15440

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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