Gene:
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5

Overview

Alternate Names: ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 5; ABCC5; ATP-binding cassette, sub-family C, member 5; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5; MRP5; canalicular multispecific organic anion transporter C
Alternate Symbols: ABC33; ABCC5; AF104942.1; DKFZp686C1782; EST277145; MOAT-C; MOATC; MRP5; SMRP; pABC11
PharmGKB Accession Id: PA395

Details

Cytogenetic Location: chr3 : q27.1
GP mRNA Boundary: chr3 : 185120416 - 185218421
GP Gene Boundary: chr3 : 185117416 - 185228421
Strand: minus
Product Name: ABCC5 variant 2, ABCC5 variant 3, ABCC5 variant 4, ATP-binding cassette, sub-family C, member 5, ATP-binding cassette, sub-family C, member 5 isoform 1, ATP-binding cassette, sub-family C, member 5 isoform 2, canalicular multispecific organic anion transporter C
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
nucleosides and nucleotides excl. reverse transcriptase inhibitors
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
xenobiotics
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  • FA
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Publications
  Drug Relationship Evidence
Phenotype data available No genotype data Literature annotations available Not annotated
cisplatin
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  •   
  • FA
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Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
docetaxel
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  • FA
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Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
fluorouracil
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  •   
  • PK
  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
ganciclovir
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  • PK
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Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
gemcitabine
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  • FA
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Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
irinotecan
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  • PD
  • PK
  • FA
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
mercaptopurine
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  •   
  • PK
  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
sildenafil
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
thioguanine
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  • PK
  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
zidovudine
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  • PK
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Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Adenocarcinoma
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  • PD
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
Anemia
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  • PK
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  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Brain Neoplasms
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  • PD
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
Carcinoma, Non-Small-Cell Lung
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  • FA
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Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Colonic Neoplasms
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  • PD
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
Drug Toxicity
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  • PK
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  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Heart Failure
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
Leukopenia
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  • PK
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  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Lymphoma
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  • PD
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
Melanoma
  •   
  • PD
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
Neutropenia
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  •   
  • PK
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  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Ovarian Neoplasms
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  • PD
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
Prostatic Neoplasms
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  • PD
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
Thrombocytopenia
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  •   
  • PK
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  • GN
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Curated Phenotype Datasets

These datasets are sorted alphabetically by title.

Downloads

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LinkOuts

UniProtKB Accesssion:
MRP5_HUMAN (O15440)
Ensembl ID:
ENSG00000114770
GenAtlas ID:
ABCC5
GeneCard ID:
ABCC5
SOURCE ID:
ABCC5
MutDB ID:
ABCC5
PromoLign ID:
ortho_1429
ALFRED ID:
LO010837T
HuGE ID:
ABCC5
Comparative Toxicogenomics Acc ID:
10057
ModBase:
O15440

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

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