PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
KCNE2
potassium voltage-gated channel, Isk-related family, member 2

Overview

Alternate Names: NinK-related peptide-1; cardiac voltage-gated potassium channel accessory subunit 2; human minK-related peptide 1, potassium channel subunit, MiRP1; minK-related peptide-1; minimum potassium ion channel-related peptide 1; potassium channel subunit, MiRP1; potassium voltage-gated channel subfamily E member 2; voltage-gated K+ channel subunit MIRP1
Alternate Symbols: ATFB4; LQT5; LQT6; MGC138292; MIRP1; MiRP1
PharmGKB Accession Id: PA392

Details

Cytogenetic Location: chr21 : q22.11
GP mRNA Boundary†: chr21 : 34658193 - 34665310
GP Gene Boundary†: chr21 : 34648193 - 34668310
Strand: plus
Product Name: cardiac voltage-gated potassium channel accessory subunit 2, minK-related peptide-1, minimum potassium ion channel-related peptide 1, potassium channel subunit, MiRP1, potassium voltage-gated channel subfamily E member 2, potassium voltage-gated channel, Isk-related family, member 2, voltage-gated K+ channel subunit MIRP1
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Curated Annotations (Curated Annotation)

  1. rs2234916 at chr21:34664669 in FAM165B, KCNE2
    There is conflicting evidence as to whether this SNP predisposes people to drug-induced arrhythmia.
    Variant Name:
    KCNE2:T8A
    Evidence:
    PMID:14665560
    PMID:17534376
Variant names are different names that have been used in the literature and other resources to refer to the same variant.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
  • CO
  •   
  •   
  • FA
  • GN
Publications
  Drug Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
clarithromycin
  •   
  •   
  •   
  • FA
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
sulfamethoxazole
  • CO
  •   
  •   
  • FA
  • GN
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Atrial Fibrillation
  •   
  •   
  •   
  •   
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Long QT Syndrome
  • CO
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Schizophrenia
  • CO
  •   
  •   
  •   
  • GN
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Curated Phenotype Datasets

These datasets are sorted alphabetically by title.

  1. Drug-Induced Long QT Intervals
    • Genotype data available
    • Phenotype data available
    • No literature annotations
    • Not annotated
    • PD
    Submitted by Dan Roden, MD involving ADRB1, ADRB2, KCNE1, KCNE2, KCNH2, KCNQ1, SCN5A, almokalant, amiodarone, amitriptyline, bretylium, bupivacaine, cisapride, disopyramide, dofetilide, encainide, fluconazole, haloperidol, hydroquinidine, isoflurane, itraconazole, ketoconazole, lithium, loratadine, metoclopramide, nortriptyline, procainamide, quinidine, sematilide, sotalol, sulfamethoxazole, thioridazine, trimethoprim, , Long QT Syndrome, Proarrhythmia and Torsades de Pointes

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. A chemogenomic approach to drug discovery: focus on cardiovascular diseases
  2. Genetic Associations in Drug-induced QT Prolongation and Torsades

Downloads

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LinkOuts

Entrez Gene ID:
9992
OMIM Accession:
603796
607554
611493
UCSC Genome Browser ID:
NM_005136
NM_172201
Ref Seq NM Accession:
NM_172201
Ref Seq NP Accession:
AAD28086
AAG13416
AAH93892
AAI12088
ABB00303
ABQ01239
EAX09790
EAX09791
NP_751951
Q2N1I3
Q9Y6J6
Ref Seq NT Accession:
AC_000064
AC_000153
NC_000021
NG_008804
NT_011512
NW_001838706
NW_927384
UniProtKB Accesssion:
KCNE2_HUMAN (Q9Y6J6)
Ensembl ID:
ENSG00000159197
GenAtlas ID:
KCNE2
GeneCard ID:
KCNE2
SOURCE ID:
KCNE2
MutDB ID:
KCNE2
PromoLign ID:
ortho_7911
HuGE ID:
KCNE2
Comparative Toxicogenomics Acc ID:
9992

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

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