Gene:
NR1I2
nuclear receptor subfamily 1, group I, member 2

Overview

Alternate Names: orphan nuclear receptor PXR; steroid and xenobiotic receptor
Alternate Symbols: BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR
PharmGKB Accession Id: PA378

Details

Cytogenetic Location: chr3 : q13.33
GP mRNA Boundary: chr3 : 120982021 - 121020022
GP Gene Boundary: chr3 : 120972021 - 121023022
Strand: plus
Product Name: pregnane X receptor, pregnane X receptor isoform 1, pregnane X receptor isoform 1l, pregnane X receptor isoform 2, pregnane X receptor isoform 3, steroid and xenobiotic receptor
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Introduction

View Full VIP Annotation

Overview
The NR1I2 gene codes for the pregnane X receptor (PXR)-- also referred to as pregnane activating receptor (PAR) and steroid xenobiotic receptor (SXR) )-- a member of the nuclear receptor (NR) superfamily of transcription factors that regulates the induction of many genes. (In this summary, we will use the term NR1I2 to refer to the gene and PXR to refer to the protein encoded by gene.) PXR is a well established regulator of CYP3A4 expression (references listed in Table 1), an enzyme involved in the metabolism of 40-50% of all drugs [PMID: 16954191, 9187528] as well as many other genes. The NR1I2 gene maps to chromosome 3q12-13 and has ten exons although only nine form the referemce transcript (see [PMID: 16101575] Figure 3 for a representation of exons and transcripts and section below, Splice Variants for NR1I2). The reference transcript encodes a protein of 434 amino acids and has the domain structure characteristic of the nuclear receptor superfamily: there is an N-terminus region; a DNA binding domain (DBD), consisting of two zinc fingers (amino acids 41-107); a hinge region (amino acids 107-141) and ligand binding domain (LBD) containing the ligand binding pocket and a ligand-depending activation factor (AF-2) domain (amino acids 141-434) [PMID: 16101574, 14657421]. Unique to PXR is an approximately 60 amino acid sequence in the LBD that appears to allow accommodation of a wide variety of ligands; see [PMID: 11408620, 15705662] and other references in Structure section below.

A simplified view of the steps in PXR gene regulation is as follows: PXR is activated by a ligand, forms a heterodimer with 9-cis retinoic acid receptor RXRalpha (gene= RXRA ) [PMID: 9784494, 9727070, 9489701, 11706036], that binds to specific DNA response elements in the target gene [PMID: 9784494, 9489701, 11706036, 12372848, 9727070], and induces gene expression. The full story of transcriptional regulation is much more complicated: PXR is constitutively inactive and is generally thought to reside in the nucleus regardless of the presence or absence of its inducers [PMID: 11264453, 14709632] (although work by Squires, et al [PMID: 15347657] in mouse livers, show that PXR is localized in the cytoplasm and translocates to the nucleus upon ligand binding.) Ligand-free PXR is bound to corepressors NCOR1 [PMID: 11329060] and NCOR2 (also known as the silencing mediator of retinoid and thyroid hormone receptor; SMRT) [PMID: 11329060, 16219912]; ligand binding causes dissociation of this complex [PMID: 16219912]. Ligand binding and PXR activation of gene transcription also involves recruitment of other proteins, in particular, the Steroid receptor coactivator 1 (SRC-1, gene= NCOA1 ) [PMID: 16455805, 9727070, 15650019, 17998298], but other proteins are also involved, including PGC-1 (gene= PPRC1 ) [PMID: 16455805] and Hepatic Nuclear Factor 4 alpha (gene= HNF4A ), another NR [PMID: 16455805, 12514743, 20086032] and protein arginine methyltransferase 1 (gene= PRMT1 ) another co-activator [PMID: 19144646].

Expression of NR1I2 itself is regulated by other NRs, including the glucocorticoid receptor (GR, gene= NR3C1 )[PMID: 10908304, 12511605, 16718615], HNF4A [PMID: 17827783], farnesoid X receptor (FXR, gene= NR1H4 ) [PMID: 16682417] and FOXA2 [PMID: 19934400]. Expression of NR1I2 is repressed by interleukin-6 [PMID: 10924340], small heterodimer partner, (SHP, gene= NR0B2 ), another NR [PMID: 12805410, 16455805], NF-kb p65 (gene= RELA ) [PMID: 16608838] and protein kinase c alpha (gene= PRKCA ) [PMID: 15710363]; consequently repression of PXR-mediated CYP3A4 induction occurs.

Gene Targets
PXR, like other NRs, regulates transcription of many genes, in particular those genes that metabolize and transport drugs. The most-studied PXR gene target is CYP3A4 ; see Table 1 for list of references. Other gene targets listed in Table 1 and identified via functional assays include ABCB1 [PMID: 11329060, 20041327, 11297522], ABCC2 [PMID: 11466304, 11706036], ABCC3 [PMID: 11323161], ALAS1 [PMID: 12181440], AHR [PMID: 12181440], ALDH1A1 [PMID: 12181440], CYP1A1 [PMID: 12181440, 19326768], CYP1A2 [PMID: 12181440, 10820139], CYP2A6 [PMID: 12181440, 19326768], CYP2B6 [PMID: 16718615, 12181440, 11560876, 18096673, 19326768, 15761118, 19520773, 9157990, 10820139], CYP2C8 [PMID: 12181440, 11329060, 9157990], CYP2C9 [PMID: 16718615, 12181440, 11560876, 18096673, 19369937, 17513950, 11466304, 9157990, 11714868, 14600250], CYP3A5 [PMID: 18725505, 15252010], GSTA2 [PMID: 12181440], POR [PMID: 12181440], SULT1A1 [PMID: 12181440]. Additionally, PXR DNA binding elements have been found in other genes, via in silico analysis, then verified experimentally; these genes are UGT1A6 [PMID: 15316010], UGT1A3 [PMID: 15316010, 15077869], UGT1A4 [PMID: 15077869], CASP10 [PMID: 15316010]. Microarray experiments [PMID: 11714868] with rifampin identified other genes presumed to be PXR targets: CYP2A6 , CYP3A7 , CYP4F3 , CYP1B1 , GSTA1 , GSTA3SLC22A5 , TTR , MAOB , FMO4 , FMO5 , GSTA2 , GSTM1 , GSTP1. There are conflicting data about UGT1A1 [PMID: 15077869, 16718615, 12181440, 15316010], CYP1A2 [PMID: 11714868, 12181440], CYP2E1 [PMID: 11714868, 12181440].

In addition to transactivation of genes, PXR is also involved with inhibition/repression: Rifampin-liganded PXR suppresses SULT2A1 expression by interfering with HNF4A activity [PMID: 17687072]; PXR inhibits CYP7A1 gene transcription [PMID: 15331348]; activation of PXR by rifampin and other agonists inhibits NF-kB signaling [PMID: 16841097]. PXR is also involved in regulation of CYP4F12 that does not involve rifampin [PMID: 19129222].

Curated Annotations (Curated Annotation)

  1. rs2472677 at chr3:121001107 in NR1I2
    The CC homozygote of the NR1I2:63396C>T variant is associated with a high level of NR1I2 (PXR) gene induction by rifampicin as measured by increased activity of CYP3A4. This observation was particularly pronounced in livers from male subjects. Samples with the T allele had higher basal levels of NR1I2 mRNA and higher basal activity of CYP3A4. This SNP is predicted to be within a FOXA2 (HNF3beta) transcription factor binding site. This SNP is in LD with 63704G>A (rs12492296), 63813(CAAA)n/(CA)n, and 65104T>C.
    Variant Name:
    NR1I2:63396C>T, PXR 63396C>T
    Related Drugs:
    rifampin
    Evidence:
    PMID:17925385
  2. rs2461823 at chr3:121002815 in NR1I2
    Risk or phenotype-associated allele: A. Phenotype: The multimarker composed of rs2461823/A-rs7643645/G was significantly associated with severity of nonalcoholic fatty liver disease (NAFLD). Study size: 290. Study population/ethnicity: 188 NAFLD patients with different stages of disease severity and 102 healthy individuals. metric(s): P<6.9x10, beta: 0.45. Type of association: GN.
    Related Diseases:
    Fatty Liver
    Evidence:
    PMID:19940802
  3. rs7643645 at chr3:121008187 in NR1I2
    Risk or phenotype-associated allele: G. Phenotype: The multimarker composed of rs2461823/A-rs7643645/G was significantly associated with severity of nonalcoholic fatty liver disease (NAFLD) (P<6.9x10, beta: 0.45). In univariate analysis rs7643645/G was significantly associated with fatty liver disease (P<0.04), with an odds ratio of 1.457 (95% confidence interval: 1.018-2.086). Study size: 290. Study population/ethnicity: 188 NAFLD patients with different stages of disease severity and 102 healthy individuals. Type of association: GN.
    Related Diseases:
    Fatty Liver
    Evidence:
    PMID:19940802
  4. rs59371185 at chr3:121008839 in NR1I2
    cell based studies; transcription and induction same as WT
    Variant Name:
    E18K
    Evidence:
    PMID:11602521
  5. rs12721613 at chr3:121008866 in NR1I2
    cell based studies; transcription and induction same as WT
    Variant Name:
    P27S
    Evidence:
    PMID:11602521
  6. rs12721613 at chr3:121008866 in NR1I2
    study of 54 livers; variant not associated with altered midazolam clearance
    Variant Name:
    g.79C>T; Pro27Ser
    Related Drugs:
    midazolam
    Evidence:
    PMID:17050801
  7. rs12721607 at chr3:121008893 in NR1I2
    cell based studies; increased induction w/ corticosterone
    Variant Name:
    G36R
    Evidence:
    PMID:11602521
  8. rs1464603 at chr3:121009039 in NR1I2
    risk allele: G; part of haplotype g.252A>G (rs1464603), g.275A>G (rs1464602), and g.4760G>A ; AF364606 significantly (P < .05) associated with oral midazolam clearance in the African American subpopulation (n = 14) but not in European Americans (n = 9).
    Variant Name:
    g.252A>G
    Related Drugs:
    midazolam
    Evidence:
    PMID:17050801
  9. rs1464602 at chr3:121009062 in NR1I2
    risk allele: G; part of haplotype g.252A>G (rs1464603), g.275A>G (rs1464602), and g.4760G>A ; AF364606 significantly (P < .05) associated with oral midazolam clearance in the African American subpopulation (n = 14) but not in European Americans (n = 9).
    Variant Name:
    g.275A>G
    Related Drugs:
    midazolam
    Evidence:
    PMID:17050801
  10. rs72551371 at chr3:121011692 in NR1I2
    cell-based studies; failed to transactivate the CYP3A4; doesn't bind DNA
    Variant Name:
    R98C
    Evidence:
    PMID:14709632
  11. rs12721608 at chr3:121013109 in NR1I2
    The variant NR1I2 R122Q protein had significantly decreased affinity for the PXR binding sequence in electromobility shift assays. In a transient transfection assays this SNP showed attenuated ligand activation of the CYP3A4 reporter plasmids. The study reports that the person heterozygous for PXR*4 is normal for CYP3A4 metabolism phenotype.
    Variant Name:
    NR1I2: PXR*4; R122Q; 4321G>A
    Evidence:
    PMID:11668216
  12. rs72551372 at chr3:121013162 in NR1I2
    cell based studies; enhanced basal activity of cyp3a4 transcription wrt WT
    Variant Name:
    V140M
    Related Drugs:
    rifampin
    Evidence:
    PMID:11602521
  13. rs72551373 at chr3:121013187 in NR1I2
    cell-based studies; similar to WT
    Variant Name:
    R148Q
    Evidence:
    PMID:14709632
  14. rs72551374 at chr3:121013232 in NR1I2
    cell based studies; decreased basal activity on cyp3a4 transcription wrt WT; increased fold induction w/ rifampicin
    Variant Name:
    D163G
    Related Drugs:
    rifampin
    Evidence:
    PMID:11602521
  15. rs35761343 at chr3:121017316 in NR1I2
    cell based studies; enhanced basal activity on cyp3a4 transcription wrt WT
    Variant Name:
    A370T
    Evidence:
    PMID:11602521
  16. rs35761343 at chr3:121017316 in NR1I2
    cell based studies; transcription and induction same as WT
    Variant Name:
    A370T
    Evidence:
    PMID:11602521
  17. rs72551375 at chr3:121017349 in NR1I2
    cell-based studies; reduced fold induction or same as WT in transactivation of CYP3A4, depending upon ligand
    Variant Name:
    R381W
    Evidence:
    PMID:14709632
  18. rs72551376 at chr3:121018651 in NR1I2
    cell-based studies; reduced fold induction or same as WT in transactivation of CYP3A4, depending upon ligand
    Variant Name:
    I403V
    Evidence:
    PMID:14709632
Variant names are different names that have been used in the literature and other resources to refer to the same variant.

Curated Information

The following genes are in curated knowledge about this gene.

  Gene Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Has annotations
ABCB1
  •   
  •   
  • PK
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
ABCC2
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data Genotype Data Available Literature annotations available Has annotations
AHR
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
ALAS1
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data Genotype Data Available Literature annotations available Has annotations
ALDH1A1
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data Genotype Data Available Literature annotations available Not annotated
CYP1A1
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data Genotype Data Available Literature annotations available Not annotated
CYP1A2
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
CYP1B1
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data Genotype Data Available Literature annotations available Has annotations
CYP2A6
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
CYP2B6
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
CYP2C9
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data Genotype Data Available Literature annotations available Not annotated
CYP2E1
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
CYP3A
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
CYP3A4
  •   
  •   
  • PK
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
CYP3A5
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data Genotype Data Available Literature annotations available Not annotated
CYP3A7
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data Genotype Data Available Literature annotations available Not annotated
GSTA2
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
NCOA1
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
NCOR2
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data Genotype Data Available Literature annotations available Not annotated
POR
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
RXRA
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
SREBF1
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
SULT1A1
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
UGT1A1
  •   
  •   
  •   
  • FA
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antineoplastic agents
  •   
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
artemisinin and derivatives
  • CO
  • PD
  • PK
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
non-nucleoside reverse transcriptase inhibitors
  •   
  • PD
  • PK
  •   
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
protease inhibitors
  •   
  • PD
  • PK
  •   
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
vitamin d and analogues
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
xenobiotics
  •   
  •   
  •   
  •   
  • GN
Publications
  Drug Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
amlodipine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
amoxicillin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
ampicillin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
artemisinin
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
aspirin
  •   
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
atorvastatin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
bexarotene
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
bosentan
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
budesonide
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
bupropion
  • CO
  • PD
  • PK
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
carbamazepine
  • CO
  • PD
  • PK
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
cefaclor
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
cefadroxil
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
cefradine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
cefuroxime
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
celecoxib
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
cephalexin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
chlorpromazine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
clindamycin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
clotrimazole
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
cyclophosphamide
  • CO
  • PD
  • PK
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
cyclosporine
  •   
  •   
  • PK
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
demeclocycline
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
dexamethasone
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
diclofenac
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
dicloxacillin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
diethylstilbestrol
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
diltiazem
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
docetaxel
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
doxorubicin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
doxycycline
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
econazole
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
efavirenz
  • CO
  • PD
  • PK
  • FA
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
erythromycin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
estradiol
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
estriol
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
estrone
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
etoposide
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
felodipine
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
flurbiprofen
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
flutamide
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
fluvastatin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
forskolin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
glibenclamide
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
glimepiride
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
griseofulvin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
GS-9350
  •   
  • PD
  • PK
  •   
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
haloperidol
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
hydrocortisone
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
ifosfamide
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
isotretinoin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
isradipine
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
ketoconazole
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
lansoprazole
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
loratadine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
lovastatin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
meclizine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
meloxicam
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
mephenytoin
  • CO
  • PD
  • PK
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
methadone
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
metyrapone
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
miconazole
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
midazolam
  •   
  •   
  • PK
  • FA
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
mifepristone
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
minocycline
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
montelukast
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
nabumetone
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
nafcillin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
naloxone
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
nevirapine
  • CO
  • PD
  • PK
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
nicardipine
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
nifedipine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
omeprazole
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
ondansetron
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
oxcarbazepine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
oxiconazole
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
paclitaxel
  •   
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
penicillin v
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
permethrin
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
phenobarbital
  • CO
  • PD
  • PK
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
phenylbutazone
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
phenytoin
  • CO
  • PD
  • PK
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
pioglitazone
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
pravastatin
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
prednisolone
  •   
  •   
  • PK
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
progesterone
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
quinapril
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
rabeprazole
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
raloxifene
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
reserpine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
rifabutin
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
rifampin
  • CO
  • PD
  • PK
  • FA
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
rifapentine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
ritonavir
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
rosiglitazone
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
saquinavir
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
sildenafil
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available No genotype data Literature annotations available Not annotated
simvastatin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
spironolactone
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
st. john's wort
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
sulfamethazine
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
sulfamethoxazole
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
sulfinpyrazone
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
sulfisoxazole
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
tamoxifen
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
terbinafine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
tetracycline
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
topotecan
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
triazolam
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
troglitazone
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
troleandomycin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
valproic acid
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
vinblastine
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
vincristine
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
zolpidem
  •   
  •   
  •   
  • FA
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
aspirin-induced asthma
  •   
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Epilepsy
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Fatty Liver
  •   
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
HIV
  • CO
  • PD
  • PK
  •   
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
HIV Infections
  •   
  • PD
  • PK
  •   
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Inflammatory Bowel Diseases
  •   
  •   
  •   
  •   
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Leukemia
  • CO
  • PD
  • PK
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Osteosarcoma
  •   
  •   
  •   
  • FA
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Curated Phenotype Datasets

These datasets are sorted alphabetically by title.

Downloads

You must sign in before you can download data.

LinkOuts

Ref Seq NT Accession:
AC_000046
AC_000135
NC_000003
NG_011856
NT_005612
NW_001838881
NW_921807
UniProtKB Accesssion:
NR1I2_HUMAN (O75469)
Ensembl ID:
ENSG00000144852
GenAtlas ID:
NR1I2
GeneCard ID:
NR1I2
SOURCE ID:
NR1I2
MutDB ID:
NR1I2
PromoLign ID:
ortho_1709
HuGE ID:
NR1I2
Comparative Toxicogenomics Acc ID:
8856
ModBase:
Q9UJ26

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

PharmGKB® is a registered trademark of HHS and is financially supported by NIH/NIGMS. It is managed at Stanford University (GM61374).
©2001-2010 PharmGKB.