PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
ABCC3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3

Overview

Alternate Names: ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 3; ABCC3; ATP-binding cassette, sub-family C, member 3; CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER2; CMOAT2; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 3; MRP3; canicular multispecific organic anion transporter; multidrug resistance associated protein
Alternate Symbols: ABC31; ABCC3; AF085690.1; CMOAT2; DKFZp686E22157; EST90757; MLP2; MOAT-D; MRP3; cMOAT2
PharmGKB Accession Id: PA376

Details

Cytogenetic Location: chr17 : q21.33
GP mRNA Boundary†: chr17 : 46067227 - 46124062
GP Gene Boundary†: chr17 : 46057227 - 46127062
Strand: plus
Product Name: ATP-binding cassette, sub-family C, member 3, ATP-binding cassette, sub-family C, member 3 isoform MRP3, ATP-binding cassette, sub-family C, member 3 isoform MRP3A, ATP-binding cassette, sub-family C, member 3 isoform MRP3B, canicular multispecific organic anion transporter, multidrug resistance associated protein
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antineoplastic agents
  •   
  • PD
  • PK
  •   
  • GN
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
opioids
  •   
  •   
  • PK
  •   
  •   
Pathways
  Drug Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
capecitabine
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
cisplatin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
codeine
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
cyanocobalamin
  •   
  • PD
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
dexamethasone
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
dimethyl sulfoxide
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
doxorubicin
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
etoposide
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
fluorouracil
  •   
  •   
  • PK
  • FA
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
folic acid
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
gemcitabine
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
irinotecan
  •   
  • PD
  •   
  • FA
  •   
Publications
Phenotype data available No genotype data Literature annotations available Not annotated
leucovorin
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
methotrexate
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
morphine
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pyridoxine
  •   
  • PD
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
rifampin
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
tegafur
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
teniposide
  •   
  •   
  •   
  • FA
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Adenocarcinoma
  •   
  • PD
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Arthritis, Rheumatoid
  •   
  • PD
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Brain Neoplasms
  •   
  • PD
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Breast Neoplasms
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Carcinoma, Basal Cell
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Carcinoma, Non-Small-Cell Lung
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Cardiomyopathy, Dilated
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Cardiomyopathy, Hypertrophic
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
Cardiomyopathy, Restrictive
  •   
  • PD
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
Chagas Cardiomyopathy
  •   
  • PD
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Colonic Neoplasms
  •   
  • PD
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Colorectal Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
Gallbladder Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Gastrointestinal Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Head and Neck Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Leukemia
  •   
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Liver Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Lung Neoplasms
  •   
  • PD
  • PK
  • FA
  • GN
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Lymphoma
  •   
  • PD
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Melanoma
  •   
  • PD
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Neoplasms
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Opioid-Related Disorders
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Ovarian Neoplasms
  •   
  • PD
  • PK
  • FA
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Pain
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Pancreatic Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Precursor Cell Lymphoblastic Leukemia-Lymphoma
  •   
  • PD
  • PK
  •   
  •   
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Prostatic Neoplasms
  •   
  • PD
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Stomach Neoplasms
  •   
  •   
  • PK
  •   
  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Curated Phenotype Datasets

These datasets are sorted alphabetically by title.

  1. Folate pathway gene expression and methotrexate pharmacodynamics
    • Genotype data available
    • Phenotype data available
    • No literature annotations
    • Not annotated
    • PD
    • PK
    • FA
    Submitted by Mary Relling, PharmD involving ABCB1, ABCC1, ABCC3, ABCC4, ABCG2, ALDH1L1, AMT, ATIC, DHFR, FPGS, FTH1, GART, GCH1, GGH, MTHFD1, MTHFD2, MTHFS, MTR, PPAT, PTS, RFC1, RUVBL2, TYMS, methotrexate, and Precursor Cell Lymphoblastic Leukemia-Lymphoma
  2. Protein expression of genes in the irinotecan pathway
    • Genotype data available
    • Phenotype data available
    • No literature annotations
    • Not annotated
    • FA
    Submitted by Howard McLeod, PharmD involving ABCB1, ABCC1, ABCC2, ABCC3, ABCC5, ABCG2, CES2, CYP3A4, CYP3A5, TOP1, UGT1A1, irinotecan, and Neoplasms
  3. RNA expression in metabolite and transport genes
    • Genotype data available
    • Phenotype data available
    • No literature annotations
    • Not annotated
    • FA
    Submitted by Howard McLeod, PharmD involving ABCB1, ABCC1, ABCC2, ABCC3, ABCC4, ABCG2, ATM, ATR, BAK1, BAX, BCL2, BCL2L1, CCNA2, CCND1, CDA, CDC2, CDC25C, CDC37, CDC45L, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CES1, CES2, CYP3A4, CYP3A5, DCK, DDB1, DHFR, DPYD, DPYS, DRG1, DTYMK, DUT, E2F1, ECGF1, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, FASLG, FDXR, FPGS, GGH, GSTM1, GSTP1, HMGB1, MAP4, MLH1, MPO, MSH2, MSH6, MTHFR, NFKB1, NME1, NME2, NT5C, PARP1, POLB, POLH, PTGS1, PTGS2, RAD9A, RB1, RRM1, RRM2, SOD1, TDP1, TK1, TOP1, TOP2A, TP53, TUBB, TYMS, UCK2, UGT1A1, UMPS, UNG, UPB1, UPP1, XPA, XPC, XRCC1, and Colonic Neoplasms

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LinkOuts

Entrez Gene ID:
8714
OMIM Accession:
604323
UCSC Genome Browser ID:
NM_003786
Ref Seq NM Accession:
NM_001144070
NM_003786
Ref Seq NP Accession:
AAB71756
AAC34668
AAD01430
AAD02845
AAD02846
AAD02847
AAD04170
AAD38185
AAH46126
AAH50370
AAI04953
AAI37348
AAI37349
BAA28146
BAD92191
CAA76658
CAC69553
EAW94590
EAW94591
EAW94592
EAW94593
EAW94594
NP_001137542
NP_003777
O15438
Q2M3C9
Q59H05
Q86VN9
Q86X85
Q96QA9
Ref Seq NT Accession:
AC_000060
AC_000149
NC_000017
NT_010783
NW_001838448
NW_926894
UniProtKB Accesssion:
MRP3_HUMAN (O15438)
Ensembl ID:
ENSG00000108846
GenAtlas ID:
ABCC3
GeneCard ID:
ABCC3
SOURCE ID:
ABCC3
MutDB ID:
ABCC3
PromoLign ID:
ortho_6478
ALFRED ID:
LO011253M
HuGE ID:
ABCC3
Comparative Toxicogenomics Acc ID:
8714
ModBase:
O15438

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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