Gene:
ABCC3
ATP-binding cassette, sub-family C (CFTR/MRP), member 3

Overview

Alternate Names: ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 3; ABCC3; ATP-binding cassette, sub-family C, member 3; CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER2; CMOAT2; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 3; MRP3; canicular multispecific organic anion transporter; multidrug resistance associated protein
Alternate Symbols: ABC31; ABCC3; AF085690.1; CMOAT2; DKFZp686E22157; EST90757; MLP2; MOAT-D; MRP3; cMOAT2
PharmGKB Accession Id: PA376

Details

Cytogenetic Location: chr17 : q21.33
GP mRNA Boundary: chr17 : 46067227 - 46124062
GP Gene Boundary: chr17 : 46057227 - 46127062
Strand: plus
Product Name: ATP-binding cassette, sub-family C, member 3, ATP-binding cassette, sub-family C, member 3 isoform MRP3, ATP-binding cassette, sub-family C, member 3 isoform MRP3A, ATP-binding cassette, sub-family C, member 3 isoform MRP3B, canicular multispecific organic anion transporter, multidrug resistance associated protein
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Relationship Evidence
Phenotype data available No genotype data Literature annotations available Not annotated
cisplatin
  • CO
  •   
  •   
  • FA
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
etoposide
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
fluorouracil
  •   
  •   
  • PK
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
folic acid
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
gemcitabine
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
irinotecan
  •   
  • PD
  •   
  • FA
  •   
Publications
Phenotype data available No genotype data Literature annotations available Not annotated
leucovorin
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
methotrexate
  •   
  • PD
  • PK
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
teniposide
  •   
  •   
  •   
  • FA
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Adenocarcinoma
  •   
  • PD
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Brain Neoplasms
  •   
  • PD
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Carcinoma, Non-Small-Cell Lung
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Colonic Neoplasms
  •   
  • PD
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Leukemia
  •   
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Lymphoma
  •   
  • PD
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Melanoma
  •   
  • PD
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Ovarian Neoplasms
  •   
  • PD
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Prostatic Neoplasms
  •   
  • PD
  •   
  • FA
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Curated Phenotype Datasets

These datasets are sorted alphabetically by title.

Downloads

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LinkOuts

UniProtKB Accesssion:
MRP3_HUMAN (O15438)
Ensembl ID:
ENSG00000108846
GenAtlas ID:
ABCC3
GeneCard ID:
ABCC3
SOURCE ID:
ABCC3
MutDB ID:
ABCC3
PromoLign ID:
ortho_6478
ALFRED ID:
LO011253M
HuGE ID:
ABCC3
Comparative Toxicogenomics Acc ID:
8714
ModBase:
O15438

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

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