Overview
| Alternate Names: | ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 3; ABCC3; ATP-binding cassette, sub-family C, member 3; CANALICULAR MULTISPECIFIC ORGANIC ANION TRANSPORTER2; CMOAT2; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 3; MRP3; canicular multispecific organic anion transporter; multidrug resistance associated protein |
|---|---|
| Alternate Symbols: | ABC31; ABCC3; AF085690.1; CMOAT2; DKFZp686E22157; EST90757; MLP2; MOAT-D; MRP3; cMOAT2 |
| PharmGKB Accession Id: | PA376 |
Details
| Cytogenetic Location: | chr17 : q21.33 |
|---|---|
| GP mRNA Boundary†: | chr17 : 46067227 - 46124062 |
| GP Gene Boundary†: | chr17 : 46057227 - 46127062 |
| Strand: | plus |
| Product Name: | ATP-binding cassette, sub-family C, member 3, ATP-binding cassette, sub-family C, member 3 isoform MRP3, ATP-binding cassette, sub-family C, member 3 isoform MRP3A, ATP-binding cassette, sub-family C, member 3 isoform MRP3B, canicular multispecific organic anion transporter, multidrug resistance associated protein |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
Non-Curated Information
A list of non-curated publications that mention this gene along with other genes is available.
PharmGKB Curated Pathways
- Codeine and Morphine Pathway (PK)
- Etoposide Pathway
- Fluoropyrimidine (PK)
- Methotrexate Pathway
- Vinca Alkaloids Pathway (PK)
BioCarta Pathways†
Reactome Pathways†
†
External pathways not curated by PharmGKB.
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug | Relationship | Evidence | |
|---|---|---|---|
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cisplatin |
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Publications |
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etoposide |
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Publications |
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fluorouracil |
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Publications |
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folic acid |
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Publications |
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gemcitabine |
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Publications |
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irinotecan |
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Publications |
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leucovorin |
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Publications |
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methotrexate |
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Publications |
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teniposide |
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Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this gene.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
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Adenocarcinoma |
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Publications |
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Brain Neoplasms |
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Publications |
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Carcinoma, Non-Small-Cell Lung |
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Publications |
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Colonic Neoplasms |
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Publications |
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Leukemia |
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Publications |
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Lymphoma |
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Publications |
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Melanoma |
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Publications |
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Ovarian Neoplasms |
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Publications |
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Prostatic Neoplasms |
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Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other diseases is available.
Curated Phenotype Datasets
These datasets are sorted alphabetically by title.
- RNA expression in metabolite and transport genes
- FA
Submitted by Howard McLeod, PharmD involving ABCB1, ABCC1, ABCC2, ABCC3, ABCC4, ABCG2, ATM, ATR, BAK1, BAX, BCL2, BCL2L1, CCNA2, CCND1, CDA, CDC2, CDC25C, CDC37, CDC45L, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CES1, CES2, CYP3A4, CYP3A5, DCK, DDB1, DHFR, DPYD, DPYS, DRG1, DTYMK, DUT, E2F1, ECGF1, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, FASLG, FDXR, FPGS, GGH, GSTM1, GSTP1, HMGB1, MAP4, MLH1, MPO, MSH2, MSH6, MTHFR, NFKB1, NME1, NME2, NT5C, PARP1, POLB, POLH, PTGS1, PTGS2, RAD9A, RB1, RRM1, RRM2, SOD1, TDP1, TK1, TOP1, TOP2A, TP53, TUBB, TYMS, UCK2, UGT1A1, UMPS, UNG, UPB1, UPP1, XPA, XPC, XRCC1, and Colonic Neoplasms
Downloads
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LinkOuts
- Entrez Gene ID:
- 8714
- OMIM Accession:
- 604323
- UCSC Genome Browser ID:
- NM_003786
- Ref Seq NM Accession:
- NM_001144070
- NM_003786
- Ref Seq NP Accession:
- AAB71756
- AAC34668
- AAD01430
- AAD02845
- AAD02846
- AAD02847
- AAD04170
- AAD38185
- AAH46126
- AAH50370
- AAI04953
- AAI37348
- AAI37349
- BAA28146
- BAD92191
- CAA76658
- CAC69553
- EAW94590
- EAW94591
- EAW94592
- EAW94593
- EAW94594
- NP_001137542
- NP_003777
- O15438
- Q2M3C9
- Q59H05
- Q86VN9
- Q86X85
- Q96QA9
- Ref Seq NT Accession:
- AC_000060
- AC_000149
- NC_000017
- NT_010783
- NW_001838448
- NW_926894
- UniProtKB Accesssion:
- MRP3_HUMAN (O15438)
- Ensembl ID:
- ENSG00000108846
- GenAtlas ID:
- ABCC3
- GeneCard ID:
- ABCC3
- SOURCE ID:
- ABCC3
- MutDB ID:
- ABCC3
- PromoLign ID:
- ortho_6478
- ALFRED ID:
- LO011253M
- HuGE ID:
- ABCC3
- Comparative Toxicogenomics Acc ID:
- 8714
- ModBase:
- O15438
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.