Gene:
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11

Overview

Alternate Names: ABC member 16, MDR/TAP subfamily; ATP-BINDING CASSETTE, SUBFAMILY B, MEMBER 11; ABCB11; BILE SALT EXPORT PUMP; BSEP; Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), mRNA.; SISTER OF P-GLYCOPROTEIN; SPGP; bile salt export pump; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein
Alternate Symbols: ABC16; ABCB11; BRIC2; BSEP; NM_003742.1; PFIC-2; PFIC2; PGY4; SPGP
PharmGKB Accession Id: PA374

Details

Cytogenetic Location: chr2 : q31.1
GP mRNA Boundary: chr2 : 169487695 - 169596079
GP Gene Boundary: chr2 : 169484695 - 169606079
Strand: minus
Product Name: ABC member 16, MDR/TAP subfamily, ATP-binding cassette, sub-family B (MDR/TAP), member 11, bile salt export pump, progressive familial intrahepatic cholestasis 2, sister p-glycoprotein
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
hmg coa reductase inhibitors
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
vinca alkaloids and analogues
  •   
  •   
  • PK
  •   
  •   
Pathways
  Drug Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
atorvastatin
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
fluvastatin
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
lovastatin
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pravastatin
  •   
  •   
  • PK
  •   
  • GN
Publications, Pathways
No phenotype data No genotype data Literature annotations available Not annotated
rosuvastatin
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
simvastatin
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
vinblastine
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
vincristine
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
vindesine
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
vinorelbine
  •   
  •   
  • PK
  •   
  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Cardiovascular Diseases
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Cholestasis
  •   
  • PD
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Drug Toxicity
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Hodgkin Disease
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Hypercholesterolemia
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Hyperlipidemias
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Hyperlipoproteinemia Type II
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Liver Diseases
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Lymphoma, Non-Hodgkin
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Multiple Myeloma
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Muscular Diseases
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Myalgia unspecified
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Myocardial Infarction
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Myositis
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Neoplasms
  • CO
  • PD
  • PK
  •   
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Precursor Cell Lymphoblastic Leukemia-Lymphoma
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Rhabdomyolysis
  •   
  •   
  • PK
  •   
  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. FXR*1B Genotype Is Associated with Reduced Hepatic FXR Target Gene Expression

Downloads

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LinkOuts

UniProtKB Accesssion:
ABCBB_HUMAN (O95342)
Ensembl ID:
ENSG00000073734
GenAtlas ID:
ABCB11
GeneCard ID:
ABCB11
SOURCE ID:
ABCB11
MutDB ID:
ABCB11
PromoLign ID:
ortho_857
ALFRED ID:
LO007786C
HuGE ID:
ABCB11
Comparative Toxicogenomics Acc ID:
8647
ModBase:
O95342

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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