PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11

Overview

Alternate Names: ABC member 16, MDR/TAP subfamily; ATP-BINDING CASSETTE, SUBFAMILY B, MEMBER 11; ABCB11; BILE SALT EXPORT PUMP; BSEP; Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), mRNA.; SISTER OF P-GLYCOPROTEIN; SPGP; bile salt export pump; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein
Alternate Symbols: ABC16; ABCB11; BRIC2; BSEP; NM_003742.1; PFIC-2; PFIC2; PGY4; SPGP
PharmGKB Accession Id: PA374

Details

Cytogenetic Location: chr2 : q31.1
GP mRNA Boundary†: chr2 : 169487695 - 169596079
GP Gene Boundary†: chr2 : 169484695 - 169606079
Strand: minus
Product Name: ABC member 16, MDR/TAP subfamily, ATP-binding cassette, sub-family B (MDR/TAP), member 11, bile salt export pump, progressive familial intrahepatic cholestasis 2, sister p-glycoprotein
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
pravastatin
  •   
  •   
  • PK
  •   
  • GN
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Cholestasis
  •   
  • PD
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Drug Toxicity
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Liver Diseases
  • CO
  •   
  •   
  •   
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Neoplasms
  • CO
  • PD
  • PK
  •   
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. FXR*1B Genotype Is Associated with Reduced Hepatic FXR Target Gene Expression

Downloads

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LinkOuts

Entrez Gene ID:
8647
OMIM Accession:
601847
603201
605479
UCSC Genome Browser ID:
NM_003742
Ref Seq NM Accession:
NM_003742
Ref Seq NP Accession:
AAC77455
AAD28285
AAY24100
AAY24305
BAA88711
BAG63812
BAG64170
CAI54162
EAX11285
EAX11286
EAX11287
NP_003733
O95342
Q53S60
Q53TL2
Q9UIL3
Ref Seq NT Accession:
AC_000045
AC_000134
NC_000002
NG_007374
NT_005403
NW_001838860
NW_921585
UniProtKB Accesssion:
ABCBB_HUMAN (O95342)
Ensembl ID:
ENSG00000073734
GenAtlas ID:
ABCB11
GeneCard ID:
ABCB11
SOURCE ID:
ABCB11
MutDB ID:
ABCB11
PromoLign ID:
ortho_857
ALFRED ID:
LO007786C
HuGE ID:
ABCB11
Comparative Toxicogenomics Acc ID:
8647
ModBase:
O95342

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

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