PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2

Overview

Alternate Names: K+ channel beta-2 subunit; OTTHUMP00000000874; OTTHUMP00000000875; OTTHUMP00000000877; Potassium voltage-gated channel, shaker-related subfamily, beta; potassium channel shaker chain beta 2
Alternate Symbols: AKR6A5; HKVBETA2.1; HKVBETA2.2; HKvbeta2; HKvbeta2.1; HKvbeta2.2; KCNA2B; KV-BETA-2; MGC117289
PharmGKB Accession Id: PA373

Details

Cytogenetic Location: chr1 : p36.31
GP mRNA Boundary†: chr1 : 6008967 - 6083110
GP Gene Boundary†: chr1 : 5998967 - 6086110
Strand: plus
Product Name: K+ channel beta-2 subunit, potassium channel shaker chain beta 2, potassium voltage-gated channel, shaker-related subfamily, beta member 2, potassium voltage-gated channel, shaker-related subfamily, beta member 2 isoform 1, potassium voltage-gated channel, shaker-related subfamily, beta member 2 isoform 2
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
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  • PD
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Pathways
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
amiodarone
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
arsenic trioxide
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
cisapride
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
disopyramide
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
dofetilide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
droperidol
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
flecainide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
halofantrine
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
haloperidol
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
ibutilide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
lidocaine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mesoridazine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
methadone
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mexiletine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pentamidine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pimozide
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
procainamide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
propafenone
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
quinidine
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
sotalol
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
sparfloxacin
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  • PD
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Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
thioridazine
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  • PD
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Pathways
No phenotype data No genotype data No literature annotations Not annotated
tocainide
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  • PD
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Pathways

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Motor Neuron Disease
  • CO
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  •   
  • FA
  • GN
Publications
The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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