PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2

Overview

Alternate Names: None
Alternate Symbols: GLUT2
PharmGKB Accession Id: PA35876

Details

Cytogenetic Location: chr3 : q26.2
GP mRNA Boundary†: chr3 : 172196831 - 172227462
GP Gene Boundary†: chr3 : 172193831 - 172237462
Strand: minus
Product Name: solute carrier family 2 (facilitated glucose transporter), member 2
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Curated Annotations (Curated Annotation)

  1. rs11920090 at chr3:172200215 in SLC2A2
    Phenotype : In a meta-analysis of 21 GWAS cohorts followed by analysis in additional individuals, this SNP was found to be associated with fasting glucose level. Study size: 119,024. Significance metric(s): p = 8.1 x 10(-13). Study population/ethnicity: Non-diabetic Individuals of European descent. Type of association: CO;GN.
    Related Diseases:
    Diabetes Mellitus, Type 2
    Evidence:
    PMID:20081858
Variant names are different names that have been used in the literature and other resources to refer to the same variant.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Relationship Evidence
No phenotype data No genotype data No literature annotations Not annotated
chlorpropamide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
gliclazide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
glimepiride
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
glipizide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
glucose
  •   
  •   
  • PK
  •   
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
nateglinide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
repaglinide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
tolbutamide
  •   
  • PD
  •   
  •   
  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Diabetes Mellitus
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Diabetes Mellitus, Type 2
  • CO
  •   
  •   
  • FA
  • GN
Publications, Variants

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

LinkOuts

Entrez Gene ID:
6514
OMIM Accession:
138160
227810
UCSC Genome Browser ID:
NM_000340
Ref Seq NM Accession:
NM_000340
Ref Seq NP Accession:
AAA59514
AAH60041
BAF83535
BAF85430
BAG36383
BAH12783
EAW78498
EAW78499
EAW78500
NP_000331
P11168
Q6PAU8
Ref Seq NT Accession:
AC_000046
AC_000135
NC_000003
NG_008108
NT_005612
NW_001838884
NW_921807
UniProtKB Accesssion:
GTR2_HUMAN (P11168)
Ensembl ID:
ENSG00000163581
GenAtlas ID:
SLC2A2
GeneCard ID:
SLC2A2
SOURCE ID:
SLC2A2
MutDB ID:
SLC2A2
PromoLign ID:
ortho_1827
HuGE ID:
SLC2A2
Comparative Toxicogenomics Acc ID:
6514
ModBase:
P11168

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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