Overview
| Alternate Names: | None |
|---|---|
| Alternate Symbols: | GLUT2 |
| PharmGKB Accession Id: | PA35876 |
Details
| Cytogenetic Location: | chr3 : q26.2 |
|---|---|
| GP mRNA Boundary†: | chr3 : 172196831 - 172227462 |
| GP Gene Boundary†: | chr3 : 172193831 - 172237462 |
| Strand: | minus |
| Product Name: | solute carrier family 2 (facilitated glucose transporter), member 2 |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
Curated Annotations (
)
-
rs11920090
at chr3:172200215
in
SLC2A2
Phenotype : In a meta-analysis of 21 GWAS cohorts followed by analysis in additional individuals, this SNP was found to be associated with fasting glucose level. Study size: 119,024. Significance metric(s): p = 8.1 x 10(-13). Study population/ethnicity: Non-diabetic Individuals of European descent. Type of association: CO;GN.- Related Diseases:
- Diabetes Mellitus, Type 2
- Evidence:
-
PMID:20081858
Variant names are different names that have been used in the literature and other resources to
refer to the same variant.
Non-Curated Information
A list of non-curated publications that mention this gene along with other genes is available.
PharmGKB Curated Pathways
PID Pathways†
Reactome Pathways†
- Glucose is carried across the plasma membrane by a glucose transport protein (GLUT) - (Reactome via Pathway Interaction Database)
- Glucose Regulation of Insulin Secretion - (Reactome via Pathway Interaction Database)
- Hexose uptake - (Reactome via Pathway Interaction Database)
†
External pathways not curated by PharmGKB.
Curated Information
The following drugs are in curated knowledge about this gene.
Primary phenotype data has been submitted and is available
Primary genotype data has been submitted and is available
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
exenatide |
|
Publications |
|
|
glucose |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this gene.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Diabetes Mellitus, Type 2 |
|
Publications, Variants |
Non-Curated Information
A list of non-curated publications that mention this gene along with other diseases is available.
LinkOuts
- Ref Seq NT Accession:
- AC_000046
- AC_000135
- NC_000003
- NG_008108
- NT_005612
- NW_001838884
- NW_921807
- UniProtKB Accesssion:
- GTR2_HUMAN (P11168)
- Ensembl ID:
- ENSG00000163581
- GenAtlas ID:
- SLC2A2
- GeneCard ID:
- SLC2A2
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.