Overview
| Alternate Names: | sodium channel beta-4 subunit; sodium channel, voltage-gated, type IV, beta polypeptide |
|---|---|
| Alternate Symbols: | None |
| PharmGKB Accession Id: | PA35007 |
Details
| Cytogenetic Location: | chr11 : q23.3 |
|---|---|
| GP mRNA Boundary†: | chr11 : 117509302 - 117528747 |
| GP Gene Boundary†: | chr11 : 117506302 - 117538747 |
| Strand: | minus |
| Product Name: | sodium channel, voltage-gated, type IV, beta |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
PharmGKB Curated Pathways
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug Class | Relationship | Evidence | |
|---|---|---|---|
|
|
antiarrhythmics, class i and iii |
|
Publications, Pathways |
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
|
amiodarone |
|
Pathways |
|
|
arsenic trioxide |
|
Pathways |
|
|
cisapride |
|
Pathways |
|
|
disopyramide |
|
Pathways |
|
|
dofetilide |
|
Pathways |
|
|
droperidol |
|
Pathways |
|
|
flecainide |
|
Pathways |
|
|
halofantrine |
|
Pathways |
|
|
haloperidol |
|
Pathways |
|
|
ibutilide |
|
Pathways |
|
|
lidocaine |
|
Pathways |
|
|
mesoridazine |
|
Pathways |
|
|
methadone |
|
Pathways |
|
|
mexiletine |
|
Pathways |
|
|
pentamidine |
|
Pathways |
|
|
pimozide |
|
Pathways |
|
|
procainamide |
|
Pathways |
|
|
propafenone |
|
Pathways |
|
|
quinidine |
|
Pathways |
|
|
sotalol |
|
Pathways |
|
|
sparfloxacin |
|
Pathways |
|
|
thioridazine |
|
Pathways |
|
|
tocainide |
|
Pathways |
Curated Information
The following diseases are in curated knowledge about this gene.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Atrial Fibrillation |
|
Publications |
|
|
Long QT Syndrome |
|
Publications |
LinkOuts
- Entrez Gene ID:
- 6330
- OMIM Accession:
- 608256
- 611819
- UCSC Genome Browser ID:
- NM_174934
- Ref Seq NM Accession:
- NM_001142348
- NM_001142349
- NM_174934
- NR_024527
- Ref Seq NP Accession:
- AAH35017
- AAN74584
- ACA06071
- BAG37123
- EAW67351
- EAW67352
- NP_001135820
- NP_001135821
- NP_777594
- Q8IWT1
- Ref Seq NT Accession:
- AC_000054
- AC_000143
- NC_000011
- NG_011710
- NT_033899
- NW_001838042
- NW_925173
- UniProtKB Accesssion:
- SCN4B_HUMAN (Q8IWT1)
- Ensembl ID:
- ENSG00000177098
- GenAtlas ID:
- SCN4B
- GeneCard ID:
- SCN4B
