Overview
| Alternate Names: | OTTHUMP00000058849; alpha-2-adrenergic receptor, platelet type; alpha-2A adrenoceptor; alpha-2A-adrenergic receptor; alpha-2AAR subtype C10; alpha2A adrenergic receptor |
|---|---|
| Alternate Symbols: | ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32 |
| PharmGKB Accession Id: | PA35 |
Details
| Cytogenetic Location: | chr10 : q25.2 |
|---|---|
| GP mRNA Boundary†: | chr10 : 112826911 - 112830560 |
| GP Gene Boundary†: | chr10 : 112816911 - 112833560 |
| Strand: | plus |
| Product Name: | OTTHUMP00000058849, alpha-2A-adrenergic receptor, alpha-2AAR subtype C10, alpha2A adrenergic receptor |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
Curated Annotations (
)
-
rs553668
at chr10:112829569
in
ADRA2A
Risk or phenotype-associated allele: A allele. Phenotype: There is increased risk of type 2 diabetes (OR = 1.42, p = 0.04, recessive effect) for carriers of the A allele. Among individuals with low body mass index (<24) or low C-peptide levels (<0.6), there is an increased disease risk in heterozygous subjects (OR = 1.31, p = 0.02, and OR = 1.28, p = 0.03, respectively, using an additive model). These associations were also significant after correcting for rs7903146 genotype in TCF7L2. Study size: 2830 cases and 3740 controls. Study population/ethnicity: Swedish diabetics and unrelated, ethnically-matched non-diabetic controls. Significance metric(s): OR >= 1.28, p <= 0.04. Type of association: CO; GN.- Related Diseases:
- Diabetes Mellitus, Type 2
- Evidence:
-
PMID:19965390
-
rs553668
at chr10:112829569
in
ADRA2A
Risk or phenotype-associated allele: A allele. Phenotype: Decreased fasting insulin (p = 0.0004) and impaired insulin secretion during intravenous glucose tolerance test in pancreatic islets isolated from subjects (p = 0.03). Study size: 4681. Study population/ethnicity: Replication study of Swedish control subjects. Significance metric(s): p <= 0.03. Type of association: FA; GN.- Related Diseases:
- Diabetes Mellitus, Type 2
- Evidence:
-
PMID:19965390
-
rs553668
at chr10:112829569
in
ADRA2A
Risk or phenotype-associated allele: A allele. Phenotype: ADRA2A transcript and protein overexpression in pancreatic islets (p < 0.05 for GG versus GA/AA, and for linear regression of expression versus number of risk alleles). Study size: 32. Study population/ethnicity: Human pancreatic islets isolated from Swedes. Significance metric(s): p < 0.05. Type of association: GN; FA.- Related Diseases:
- Diabetes Mellitus, Type 2
- Evidence:
-
PMID:19965390
-
rs602618
at chr10:112833075
in
ADRA2A
Risk or phenotype-associated allele: A allele. Phenotype: Decreased fasting insulin. Study size: 4681. Study population/ethnicity: Replication study of Swedish control subjects. Significance metric(s): p = 0.001. Type of association: FA; GN.- Related Diseases:
- Diabetes Mellitus, Type 2
- Evidence:
-
PMID:19965390
Variant names are different names that have been used in the literature and other resources to
refer to the same variant.
Non-Curated Information
A list of non-curated publications that mention this gene along with other genes is available.
PharmGKB Curated Pathways
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug Class | Relationship | Evidence | |
|---|---|---|---|
|
antidepressants |
|
Publications |
|
Beta Blocking Agents |
|
Publications |
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
|
clonidine |
|
Publications |
|
|
clozapine |
|
Publications |
|
|
methylphenidate |
|
Publications |
|
norepinephrine |
|
Publications |
|
|
olanzapine |
|
Publications |
|
|
sibutramine |
|
Publications |
|
|
yohimbine |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this gene.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Attention Deficit Disorder with Hyperactivity |
|
Publications |
|
|
Body Weight Changes |
|
Publications |
|
|
diabetes mellitus type 2 and obesity |
|
Publications |
|
|
Diabetes Mellitus, Type 2 |
|
Publications, Variants |
|
|
Hypertension |
|
Publications |
|
|
Obesity |
|
Publications |
|
|
Schizophrenia |
|
Publications |
|
|
Weight gain |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
Downloads
You must sign in before you can download data.
LinkOuts
- Entrez Gene ID:
- 150
- OMIM Accession:
- 104210
- UCSC Genome Browser ID:
- NM_000681
- Ref Seq NM Accession:
- NM_000681
- Ref Seq NP Accession:
- AAA51664
- AAA51665
- AAF91441
- AAG00447
- AAH35047
- AAH50414
- AAK01634
- AAK26743
- AAK51162
- AAZ73101
- ABB72683
- ABY87535
- CAH72817
- EAW49547
- NP_000672
- P08913
- Ref Seq NT Accession:
- AC_000053
- AC_000142
- NC_000010
- NT_030059
- NW_001838006
- NW_924884
- UniProtKB Accesssion:
- ADA2A_HUMAN (P08913)
- Ensembl ID:
- ENSG00000150594
- GenAtlas ID:
- ADRA2A
- GeneCard ID:
- ADRA2A
- SOURCE ID:
- ADRA2A
- MutDB ID:
- ADRA2A
- PromoLign ID:
- ortho_4190
- HuGE ID:
- ADRA2A
- Comparative Toxicogenomics Acc ID:
- 150
- ModBase:
- P08913
- IUPHAR Receptor ID:
- α2A-adrenoceptor (25)
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.