PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
POR
P450 (cytochrome) oxidoreductase

Overview

Alternate Names: Cytochrome P-450 reductase; NADPH-dependent cytochrome P450 reductase; cytochrome P450 reductase
Alternate Symbols: CPR; CYPOR; DKFZp686G04235; FLJ26468; P450R; POR
PharmGKB Accession Id: PA33532

Details

Cytogenetic Location: chr7 : q11.23
GP mRNA Boundary†: chr7 : 75421243 - 75454109
GP Gene Boundary†: chr7 : 75411243 - 75457109
Strand: plus
Product Name: Cytochrome P-450 reductase, H_RG122E10.1, NADPH-dependent cytochrome P450 reductase, P450 (cytochrome) oxidoreductase, WUGSC:H_RG122E10.1, cytochrome P450 reductase
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Curated Annotations (Curated Annotation)

  1. rs1057868 at chr7:75452942 in POR
    Risk or phenotype-associated allele: T. Phenotype: POR*28 TT genotype presents a 1.6-fold increase in CYP3A activity compared with POR*28C carriers. Study size: 251. Study population/ethnicity: Caucasian patients from two independent studies (182 patients treated with methadone and 69 patients with clozapine). Significance metric(s): (n = 182, P = 0.004); (n = 69, P = 0.04) . Type of association: GN.
    Evidence:
    PMID:19801957
Variant names are different names that have been used in the literature and other resources to refer to the same variant.

Curated Information

The following genes are in curated knowledge about this gene.

  Gene Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
CYP3A
  •   
  •   
  •   
  •   
  • GN
Publications
No phenotype data Genotype Data Available Literature annotations available Not annotated
CYP51A1
  •   
  •   
  •   
  •   
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

BioCarta Pathways†

† External pathways not curated by PharmGKB.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
vitamin d and analogues
  •   
  •   
  • PK
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
xenobiotics
  •   
  •   
  • PK
  • FA
  •   
Publications
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
etoposide
  •   
  •   
  •   
  • FA
  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
midazolam
  •   
  •   
  • PK
  • FA
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Williams Syndrome
  •   
  •   
  •   
  • FA
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Downloads

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LinkOuts

Entrez Gene ID:
5447
OMIM Accession:
124015
201750
UCSC Genome Browser ID:
NM_000941
Ref Seq NM Accession:
NM_000941
Ref Seq NP Accession:
AAB21814
AAD45961
AAG09798
AAH34277
ABF70199
BAB18572
BAD93111
BAF83218
BAG35442
BAG56734
BAG58850
BAG59240
BAG65317
CAH56151
EAW71777
EAW71778
EAW71779
EAW71780
NP_000932
P16435
Q59ED7
Q63HL4
Q9UDT3
Ref Seq NT Accession:
AC_000050
AC_000068
AC_000139
NC_000007
NG_008930
NT_007933
NT_079595
NW_001839047
NW_923484
UniProtKB Accesssion:
NCPR_HUMAN (P16435)
Ensembl ID:
ENSG00000127948
GenAtlas ID:
POR
GeneCard ID:
POR
SOURCE ID:
POR
MutDB ID:
POR
PromoLign ID:
ortho_3465
HuGE ID:
POR
Comparative Toxicogenomics Acc ID:
5447
ModBase:
P16435

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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