Gene:
POR
P450 (cytochrome) oxidoreductase

Overview

Alternate Names: Cytochrome P-450 reductase; NADPH-dependent cytochrome P450 reductase; cytochrome P450 reductase
Alternate Symbols: CPR; CYPOR; DKFZp686G04235; FLJ26468; P450R; POR
PharmGKB Accession Id: PA33532

Details

Cytogenetic Location: chr7 : q11.23
GP mRNA Boundary: chr7 : 75421243 - 75454109
GP Gene Boundary: chr7 : 75411243 - 75457109
Strand: plus
Product Name: Cytochrome P-450 reductase, H_RG122E10.1, NADPH-dependent cytochrome P450 reductase, P450 (cytochrome) oxidoreductase, WUGSC:H_RG122E10.1, cytochrome P450 reductase
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Curated Annotations (Curated Annotation)

  1. rs1057868 at chr7:75452942 in POR
    Risk or phenotype-associated allele: T. Phenotype: POR*28 TT genotype presents a 1.6-fold increase in CYP3A activity compared with POR*28C carriers. Study size: 251. Study population/ethnicity: Caucasian patients from two independent studies (182 patients treated with methadone and 69 patients with clozapine). Significance metric(s): (n = 182, P = 0.004); (n = 69, P = 0.04) . Type of association: GN.
    Evidence:
    PMID:19801957
Variant names are different names that have been used in the literature and other resources to refer to the same variant.

Curated Information

The following genes are in curated knowledge about this gene.

  Gene Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
CYP3A
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  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
CYP3A4
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data Genotype Data Available Literature annotations available Not annotated
CYP51A1
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  •   
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  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Has annotations
NR1I2
  •   
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  • FA
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

BioCarta Pathways

External pathways not curated by PharmGKB.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
vitamin d and analogues
  •   
  •   
  • PK
  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
xenobiotics
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  • PK
  • FA
  •   
Publications
  Drug Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
7-deoxydoxorubicinone
  •   
  • PD
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  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
doxorubicin
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  • PD
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  •   
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
etoposide
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  • FA
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Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
midazolam
  •   
  •   
  • PK
  • FA
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Williams Syndrome
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  •   
  •   
  • FA
  •   
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Downloads

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LinkOuts

Ref Seq NT Accession:
AC_000050
AC_000068
AC_000139
NC_000007
NG_008930
NT_007933
NT_079595
NW_001839047
NW_923484
UniProtKB Accesssion:
NCPR_HUMAN (P16435)
Ensembl ID:
ENSG00000127948
GenAtlas ID:
POR
GeneCard ID:
POR
SOURCE ID:
POR
MutDB ID:
POR
PromoLign ID:
ortho_3465
HuGE ID:
POR
Comparative Toxicogenomics Acc ID:
5447
ModBase:
P16435

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

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