Overview
| Alternate Names: | adrenergic, alpha -1B-, receptor; alpha-1B-adrenergic receptor |
|---|---|
| Alternate Symbols: | ADRA1; ALPHA1BAR |
| PharmGKB Accession Id: | PA33 |
Details
| Cytogenetic Location: | chr5 : q33.3 |
|---|---|
| GP mRNA Boundary†: | chr5 : 159276318 - 159332595 |
| GP Gene Boundary†: | chr5 : 159266318 - 159335595 |
| Strand: | plus |
| Product Name: | alpha-1B-adrenergic receptor |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
Curated Annotations (
)
-
rs10515807
at chr5:159297576
in
ADRA1B
in a GWAS of subjects of African ancestry(African American plus African Caribbean), this SNP was found to be significantly associated with Asthma . This finding was not significantly replicated in 4 additional case-control studies of African Americans nor in tested family and case-control panels of UK and German subjects. Risk or phenotype-associated allele: T. Phenotype: increased risk for asthma. Study size/population/ethnicity: 1) 935 African American asthmatic cases and control subjects from the Baltimore-Washington area (2) 929 African Caribbean asthmatic subjects and their family members from Barbados . Significance metric(s): combined p = 3.57 x 10(-6); OR = 1.40(95% CI= 1.18-1.66). Type of association: CO; GN.- Related Diseases:
- Asthma
- Evidence:
-
PMID:19910028
Variant names are different names that have been used in the literature and other resources to
refer to the same variant.
Non-Curated Information
A list of non-curated publications that mention this gene along with other genes is available.
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
norepinephrine |
|
Publications |
|
|
prazosin |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this gene.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Asthma |
|
Publications, Variants |
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
- UniProtKB Accesssion:
- ADA1B_HUMAN (P35368)
- Ensembl ID:
- ENSG00000170214
- GenAtlas ID:
- ADRA1B
- GeneCard ID:
- ADRA1B
- SOURCE ID:
- ADRA1B
- MutDB ID:
- ADRA1B
- PromoLign ID:
- ortho_2258
- ALFRED ID:
- LO003217N
- HuGE ID:
- ADRA1B
- Comparative Toxicogenomics Acc ID:
- 147
- ModBase:
- P35368
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.