Overview
| Alternate Names: | sodium channel beta-1 subunit; sodium channel, voltage-gated, type I, beta polypeptide |
|---|---|
| Alternate Symbols: | GEFSP1 |
| PharmGKB Accession Id: | PA302 |
Details
| Cytogenetic Location: | chr19 : q13.11 |
|---|---|
| GP mRNA Boundary†: | chr19 : 40213374 - 40223193 |
| GP Gene Boundary†: | chr19 : 40203374 - 40226193 |
| Strand: | plus |
| Product Name: | sodium channel, voltage-gated, type I, beta, sodium channel, voltage-gated, type I, beta isoform a, sodium channel, voltage-gated, type I, beta isoform b, sodium channel, voltage-gated, type I, beta polypeptide |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
PharmGKB Curated Pathways
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug Class | Relationship | Evidence | |
|---|---|---|---|
|
antiarrhythmics, class i and iii |
|
Publications |
|
|
Beta blocking agents, selective |
|
Publications |
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
|
carbamazepine |
|
Publications |
|
phenytoin |
|
Publications |
|
|
warfarin |
|
Publications |
Curated Information
The following diseases are in curated knowledge about this gene.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Arrhythmias, Cardiac |
|
Publications |
|
|
Atrial Fibrillation |
|
Publications |
|
|
Brugada syndrome |
|
Publications |
|
|
Cardiomyopathy, Hypertrophic |
|
Publications |
|
|
Coronary Artery Disease |
|
Publications |
|
|
Coronary Disease |
|
Publications |
|
|
Death, Sudden, Cardiac |
|
Publications |
|
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Epilepsy |
|
Publications |
|
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Heart Diseases |
|
Publications |
|
|
Long QT Syndrome |
|
Publications |
|
|
Myocardial Infarction |
|
Publications |
|
|
Sudden Infant Death |
|
Publications |
|
|
Thromboembolism |
|
Publications |
|
|
Torsades de Pointes |
|
Publications |
|
|
Ventricular Fibrillation |
|
Publications |
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
Downloads
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LinkOuts
- Ref Seq NT Accession:
- AC_000062
- AC_000151
- NC_000019
- NT_011109
- NW_001838494
- NW_927206
- UniProtKB Accesssion:
- SCN1B_HUMAN (Q07699)
- Ensembl ID:
- ENSG00000105711
- GenAtlas ID:
- SCN1B
- GeneCard ID:
- SCN1B