PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
KCNK3
potassium channel, subfamily K, member 3

Overview

Alternate Names: Kcnk3 channel; TWIK-related acid-sensitive K+ channel; acid-sensitive potassium channel protein TASK; cardiac potassium channel; potassium channel, subfamily K, member 3 (TASK); potassium channel, subfamily K, member 3 (TASK-1); potassium inwardly-rectifying channel, subfamily K, member 3; two P domain potassium channel
Alternate Symbols: K2p3.1; OAT1; TASK; TASK-1; TBAK1
PharmGKB Accession Id: PA30060

Details

Cytogenetic Location: chr2 : p23.3
GP mRNA Boundary†: chr2 : 26769123 - 26806222
GP Gene Boundary†: chr2 : 26759123 - 26809222
Strand: plus
Product Name: Kcnk3 channel, TWIK-related acid-sensitive K+ channel, acid-sensitive potassium channel protein TASK, cardiac potassium channel, potassium channel, subfamily K, member 3, potassium channel, subfamily K, member 3 (TASK), potassium channel, subfamily K, member 3 (TASK-1), potassium inwardly-rectifying channel, subfamily K, member 3, two P domain potassium channel
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
  •   
  • PD
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  • FA
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Publications, Pathways
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
amiodarone
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
arsenic trioxide
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
cisapride
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  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
disopyramide
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
dofetilide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
droperidol
  •   
  • PD
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  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
flecainide
  •   
  • PD
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  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
halofantrine
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
haloperidol
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
ibutilide
  •   
  • PD
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  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
lidocaine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mesoridazine
  •   
  • PD
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  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
methadone
  •   
  • PD
  •   
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mexiletine
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
nicotine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pentamidine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pimozide
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
procainamide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
propafenone
  •   
  • PD
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  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
quinidine
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
sotalol
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
sparfloxacin
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
thioridazine
  •   
  • PD
  •   
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  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
tocainide
  •   
  • PD
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  •   
  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Tobacco Use Disorder
  •   
  • PD
  •   
  •   
  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

LinkOuts

Entrez Gene ID:
3777
OMIM Accession:
603220
UCSC Genome Browser ID:
NM_002246
Ref Seq NM Accession:
NM_002246
Ref Seq NP Accession:
AAC51777
AAG29340
AAI40702
AAY24312
EAX00678
EAX00679
NP_002237
O14649
Q53SU2
Ref Seq NT Accession:
AC_000045
AC_000134
NC_000002
NT_022184
NW_001838768
NW_927719
UniProtKB Accesssion:
KCNK3_HUMAN (O14649)
Ensembl ID:
ENSG00000171303
GenAtlas ID:
KCNK3
GeneCard ID:
KCNK3
SOURCE ID:
KCNK3
MutDB ID:
KCNK3
PromoLign ID:
ortho_1139
HuGE ID:
KCNK3
Comparative Toxicogenomics Acc ID:
3777
ModBase:
O14649

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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