PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8

Overview

Alternate Names: ATP-sensitive inward rectifier potassium channel 8; inwardly rectifying potassium channel KIR6.1; potassium inwardly-rectifying channel J8
Alternate Symbols: KIR6.1; Kir6.1; uKATP-1
PharmGKB Accession Id: PA30050

Details

Cytogenetic Location: chr12 : p12.1
GP mRNA Boundary†: chr12 : 21809156 - 21819014
GP Gene Boundary†: chr12 : 21806156 - 21829014
Strand: minus
Product Name: ATP-sensitive inward rectifier potassium channel 8, inwardly rectifying potassium channel KIR6.1, potassium inwardly-rectifying channel J8, potassium inwardly-rectifying channel, subfamily J, member 8
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
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  • PD
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  • FA
  • GN
Publications, Pathways
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
amiodarone
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
arsenic trioxide
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
cisapride
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
disopyramide
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
dofetilide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
droperidol
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
flecainide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
halofantrine
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
haloperidol
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
ibutilide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
lidocaine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mesoridazine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
methadone
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mexiletine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pentamidine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pimozide
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
procainamide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
propafenone
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
quinidine
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
sotalol
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
sparfloxacin
  •   
  • PD
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  •   
Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
thioridazine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
tocainide
  •   
  • PD
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  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

LinkOuts

Entrez Gene ID:
3764
OMIM Accession:
600935
UCSC Genome Browser ID:
NM_004982
Ref Seq NM Accession:
NM_004982
Ref Seq NP Accession:
AAH00544
ABM82839
ABM86023
BAA08851
BAA08852
BAF84510
EAW96450
EAW96451
NP_004973
Q15842
Ref Seq NT Accession:
AC_000055
AC_000144
NC_000012
NT_009714
NW_001838052
NW_925328
UniProtKB Accesssion:
IRK8_HUMAN (Q15842)
Ensembl ID:
ENSG00000121361
GenAtlas ID:
KCNJ8
GeneCard ID:
KCNJ8
SOURCE ID:
KCNJ8
MutDB ID:
KCNJ8
PromoLign ID:
ortho_5206
HuGE ID:
KCNJ8
Comparative Toxicogenomics Acc ID:
3764
ModBase:
Q15842

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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