PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4

Overview

Alternate Names: OTTHUMP00000028922; hippocampal inward rectifier potassium channel; inward rectifier K+ channel Kir2.3; potassium inwardly-rectifying channel J4
Alternate Symbols: HIR; HIRK2; HRK1; IRK3; Kir2.3; MGC142066; MGC142068; hIRK2
PharmGKB Accession Id: PA30048

Details

Cytogenetic Location: chr22 : q13.1
GP mRNA Boundary†: chr22 : 37152278 - 37181149
GP Gene Boundary†: chr22 : 37149278 - 37191149
Strand: minus
Product Name: OTTHUMP00000028922, hippocampal inward rectifier potassium channel, inward rectifier K+ channel Kir2.3, potassium inwardly-rectifying channel J4, potassium inwardly-rectifying channel, subfamily J, member 4
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
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  • PD
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  • FA
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Publications, Pathways
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
amiodarone
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
arsenic trioxide
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
cisapride
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
disopyramide
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
dofetilide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
droperidol
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
flecainide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
halofantrine
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
haloperidol
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
ibutilide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
lidocaine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mesoridazine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
methadone
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mexiletine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pentamidine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pimozide
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
procainamide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
propafenone
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
quinidine
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
sotalol
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
sparfloxacin
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  • PD
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Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
thioridazine
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  • PD
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Pathways
No phenotype data No genotype data No literature annotations Not annotated
tocainide
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  • PD
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Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

LinkOuts

Entrez Gene ID:
3761
OMIM Accession:
600504
UCSC Genome Browser ID:
NM_004981
Ref Seq NM Accession:
NM_004981
NM_152868
Ref Seq NP Accession:
AAA19962
AAA66076
AAC60632
AAH32562
AAI13507
AAI13509
CAB09790
CAG30393
CAK54537
CAK54836
EAW60235
EAW60236
NP_004972
NP_690607
P48050
Q58F07
Ref Seq NT Accession:
AC_000065
AC_000154
NC_000022
NT_011520
NW_001838745
NW_927628
UniProtKB Accesssion:
IRK4_HUMAN (P48050)
Ensembl ID:
ENSG00000168135
GenAtlas ID:
KCNJ4
GeneCard ID:
KCNJ4
SOURCE ID:
KCNJ4
MutDB ID:
KCNJ4
PromoLign ID:
ortho_8069
HuGE ID:
KCNJ4
ModBase:
P48050

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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