PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B

Overview

Alternate Names: 5-hydroxytryptamine 3 receptor B subunit; serotonin-gated ion channel subunit
Alternate Symbols: 5-HT3B
PharmGKB Accession Id: PA29556

Details

Cytogenetic Location: chr11 : q23.2
GP mRNA Boundary†: chr11 : 113280799 - 113322493
GP Gene Boundary†: chr11 : 113270799 - 113325493
Strand: plus
Product Name: 5-hydroxytryptamine (serotonin) receptor 3B precursor, 5-hydroxytryptamine 3 receptor B subunit, serotonin-gated ion channel subunit
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Curated Annotations (Curated Annotation)

  1. rs45460698 at chr11:113280764 in HTR3B
    This study observed a significant underrepresentation of the 3 bp deletion -100_-102delAAG of the HTR3B gene promoter region in an extended sample of 162 bipolar affected patients compared to controls.
    Related Diseases:
    Psychophysiologic Disorders
    Evidence:
    PMID:15389765
  2. rs45460698 at chr11:113280764 in HTR3B
    A study in 242 cancer patients found that patients homozygous for the -100_-102delAAG deletion variant of the HTR3B promotor region experienced vomiting more frequently than all the other patients.
    Related Diseases:
    Nausea, Vomiting
    Evidence:
    PMID:12775740
  3. rs2276307 at chr11:113309097 in HTR3B
    This variant is found to be a risk marker for statin induced myalgia
    Related Drugs:
    atorvastatin, pravastatin, simvastatin
    Related Diseases:
    Myalgia unspecified
    Evidence:
    PMID:17600820
Variant names are different names that have been used in the literature and other resources to refer to the same variant.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antidepressants
  •   
  • PD
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
antineoplastic agents
  •   
  • PD
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
antipsychotics
  • CO
  • PD
  •   
  •   
  • GN
Publications
  Drug Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
atorvastatin
  • CO
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
citalopram
  •   
  • PD
  •   
  •   
  • GN
Publications
Phenotype data available No genotype data Literature annotations available Not annotated
fluoxetine
  •   
  • PD
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
fluvoxamine
  •   
  • PD
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
paroxetine
  •   
  • PD
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
pravastatin
  • CO
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
sertraline
  •   
  • PD
  •   
  •   
  • GN
Publications
Phenotype data available No genotype data Literature annotations available Not annotated
simvastatin
  • CO
  •   
  •   
  •   
  • GN
Publications, Variants

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Anorexia Nervosa
  •   
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Bipolar Disorder
  •   
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Colonic Diseases, Functional
  •   
  •   
  •   
  • FA
  • GN
Publications
Phenotype data available No genotype data Literature annotations available Not annotated
Depression
  •   
  • PD
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Depressive Disorder
  •   
  • PD
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Hypercholesterolemia
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Hyperlipidemias
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Muscular Diseases
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Myalgia unspecified
  • CO
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
Myositis
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Nausea
  •   
  • PD
  •   
  • FA
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
Postoperative Nausea and Vomiting
  •   
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Psychophysiologic Disorders
  •   
  •   
  •   
  •   
  •   
Variants
No phenotype data No genotype data Literature annotations available Not annotated
Rhabdomyolysis
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Schizophrenia
  • CO
  • PD
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Vomiting
  •   
  •   
  •   
  • FA
  • GN
Publications, Variants

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. Genetic Variants in Statin associated Adverse Events
  2. PMT06_047.xml
  3. PMT06_048.xml

LinkOuts

Entrez Gene ID:
9177
OMIM Accession:
604654
UCSC Genome Browser ID:
NM_006028
Ref Seq NM Accession:
NM_006028
Ref Seq NP Accession:
AAD12242
AAF03691
AAI41516
BAG36930
CAL25321
EAW67236
NP_006019
O95264
Ref Seq NT Accession:
AC_000054
AC_000143
NC_000011
NG_011483
NT_033899
NW_001838042
NW_925173
UniProtKB Accesssion:
5HT3B_HUMAN (O95264)
Ensembl ID:
ENSG00000149305
GenAtlas ID:
HTR3B
GeneCard ID:
HTR3B
SOURCE ID:
HTR3B
MutDB ID:
HTR3B
PromoLign ID:
ortho_4706
HuGE ID:
HTR3B
Comparative Toxicogenomics Acc ID:
9177
ModBase:
O95264
IUPHAR Receptor ID:
5-HT3B (374)

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

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