Overview
| Alternate Names: | (connexin; 43); OTTHUMP00000017111; connexin 43; gap junction 43 kDa heart protein; gap junction protein, alpha 1, 43kD; gap junction protein, alpha 1, 43kD (connexin 43); gap junction protein, alpha 1, 43kDa (connexin 43); gap junction protein, alpha-like; oculodentodigital dysplasia (syndactyly type III) |
|---|---|
| Alternate Symbols: | CX43; DFNB38; GJAL; ODD; ODDD; ODOD; SDTY3 |
| PharmGKB Accession Id: | PA28685 |
Details
| Cytogenetic Location: | chr6 : q22.31 |
|---|---|
| GP mRNA Boundary†: | chr6 : 121798487 - 121812571 |
| GP Gene Boundary†: | chr6 : 121788487 - 121815571 |
| Strand: | plus |
| Product Name: | connexin 43, gap junction protein, alpha-like, oculodentodigital dysplasia (syndactyly type III) |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
Non-Curated Information
A list of non-curated publications that mention this gene along with other genes is available.
PharmGKB Curated Pathways
BioCarta Pathways†
PID Pathways†
Reactome Pathways†
- c-src mediated regulation of Cx43 function and closure of gap junctions - (Reactome via Pathway Interaction Database)
- Gap junction assembly - (Reactome via Pathway Interaction Database)
- Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane - (Reactome via Pathway Interaction Database)
- Oligomerization of connexins into connexons - (Reactome via Pathway Interaction Database)
- Transport of connexins along the secretory pathway - (Reactome via Pathway Interaction Database)
†
External pathways not curated by PharmGKB.
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug Class | Relationship | Evidence | |
|---|---|---|---|
|
antiarrhythmics, class i and iii |
|
Publications |
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
cisplatin |
|
Publications |
|
mercaptopurine |
|
Publications |
|
|
methotrexate |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this gene.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Ovarian Neoplasms |
|
Publications |
|
|
Precursor Cell Lymphoblastic Leukemia-Lymphoma |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other diseases is available.
LinkOuts
- Entrez Gene ID:
- 2697
- OMIM Accession:
- 121014
- 164200
- 186100
- 241550
- 600309
- UCSC Genome Browser ID:
- NM_000165
- Ref Seq NM Accession:
- NM_000165
- Ref Seq NP Accession:
- AAA52131
- AAD37802
- AAH26329
- ABM84575
- ABM86537
- BAD97009
- BAG35246
- BAG57837
- BAG58393
- BAG60109
- BAG60112
- CAA37122
- CAG46461
- CAI20002
- EAW48178
- NP_000156
- P17302
- Q53FJ6
- Ref Seq NT Accession:
- AC_000049
- AC_000138
- NC_000006
- NG_008308
- NT_025741
- NW_001838990
- NW_923184
- UniProtKB Accesssion:
- CXA1_HUMAN (P17302)
- Ensembl ID:
- ENSG00000152661
- GenAtlas ID:
- GJA1
- GeneCard ID:
- GJA1
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.