PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
FKBP1B
FK506 binding protein 1B, 12.6 kDa

Overview

Alternate Names: FK506 binding protein 1B (12.6 kD); FK506-binding protein 1-like; FK506-binding protein 12.6; FK506-binding protein 1B (12.6 kD); OTTHUMP00000116040; OTTHUMP00000116041; calstabin 2; immunophilin FKBP12.6; peptidyl-prolyl cis-trans isomerase; rotamase
Alternate Symbols: FKBP12.6; FKBP1L; FKBP9; OTK4; PKBP1L; PPIase
PharmGKB Accession Id: PA28154

Details

Cytogenetic Location: chr2 : p23.3
GP mRNA Boundary†: chr2 : 24126132 - 24140055
GP Gene Boundary†: chr2 : 24116132 - 24143055
Strand: plus
Product Name: FK506 binding protein 1B (12.6 kD), FK506-binding protein 1-like, FK506-binding protein 12.6, FK506-binding protein 1B, FK506-binding protein 1B isoform a, FK506-binding protein 1B isoform b, calstabin 2, immunophilin FKBP12.6, peptidyl-prolyl cis-trans isomerase, rotamase
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
  •   
  • PD
  •   
  • FA
  • GN
Publications, Pathways
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
amiodarone
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
arsenic trioxide
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
cisapride
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
disopyramide
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
dofetilide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
droperidol
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
flecainide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
halofantrine
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
haloperidol
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
ibutilide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
lidocaine
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mesoridazine
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
methadone
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mexiletine
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pentamidine
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pimozide
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
procainamide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
propafenone
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
quinidine
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
sotalol
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
sparfloxacin
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
thioridazine
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
tocainide
  •   
  • PD
  •   
  •   
  •   
Pathways

LinkOuts

Entrez Gene ID:
2281
OMIM Accession:
600620
UCSC Genome Browser ID:
NM_004116
Ref Seq NM Accession:
NM_004116
NM_054033
Ref Seq NP Accession:
AAB30684
AAB30685
AAC37581
AAH02614
AAK11191
AAY14663
BAA07232
BAE44300
EAX00768
EAX00769
EAX00770
NP_004107
NP_473374
P68106
Ref Seq NT Accession:
AC_000045
AC_000134
NC_000002
NT_022184
NW_001838768
NW_927719
UniProtKB Accesssion:
FKB1B_HUMAN (P68106)
Ensembl ID:
ENSG00000119782
GenAtlas ID:
FKBP1B
GeneCard ID:
FKBP1B
SOURCE ID:
FKBP1B
MutDB ID:
FKBP1B
PromoLign ID:
ortho_1033
HuGE ID:
FKBP1B
Comparative Toxicogenomics Acc ID:
2281
ModBase:
P68106

Common Searches

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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