Overview
| Alternate Names: | OTTHUMP00000185030; OTTHUMP00000185033; OTTHUMP00000185037; PPAR gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferative activated receptor gamma; peroxisome proliferative activated receptor, gamma; peroxisome proliferator activated-receptor gamma; peroxisome proliferator-activated receptor gamma 1; ppar gamma2 |
|---|---|
| Alternate Symbols: | CIMT1; HUMPPARG; NR1C3; PPARG1; PPARG2; PPARgamma |
| PharmGKB Accession Id: | PA281 |
Details
| Cytogenetic Location: | chr3 : p25.2 |
|---|---|
| GP mRNA Boundary†: | chr3 : 12304359 - 12450843 |
| GP Gene Boundary†: | chr3 : 12294359 - 12453843 |
| Strand: | plus |
| Product Name: | PPAR gamma, peroxisome proliferative activated receptor gamma, peroxisome proliferative activated receptor gamma isoform 1, peroxisome proliferative activated receptor gamma isoform 2, peroxisome proliferator activated-receptor gamma, peroxisome proliferator-activated receptor gamma 1, ppar gamma2 |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
Curated Annotations (
)
-
rs1801282
at chr3:12368125
in
PPARG
In a large Finnish case-control GWAS, rs1801282 was found to be associated with susceptibility to Type 2 Diabetes.- Related Diseases:
- Diabetes Mellitus, Type 2
- Evidence:
-
PMID:17463248
-
rs1801282
at chr3:12368125
in
PPARG
Risk or phenotype-associated allele: G. Phenotype: For the Pro12Ala (rs1801282) SNP in the PPARG gene, an association was noted for the minor allele between psoriatic arthritis cases and controls (9.0% vs 13.8%, respectively; p = 0.017, OR 0.62, 95% CI 0.45-0.93). Study size: X. Study population/ethnicity: Caucasian- Variant Name:
- PPARG: Pro12Ala
- Related Diseases:
- Arthritis, Psoriatic
- Evidence:
-
PMID:16783862
Variant names are different names that have been used in the literature and other resources to
refer to the same variant.
Non-Curated Information
A list of non-curated publications that mention this gene along with other genes is available.
PharmGKB Curated Pathways
BioCarta Pathways†
- basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression - (BioCarta via Pathway Interaction Database)
- role of ppar-gamma coactivators in obesity and thermogenesis - (BioCarta via Pathway Interaction Database)
- visceral fat deposits and the metabolic syndrome - (BioCarta via Pathway Interaction Database)
PID Pathways†
- Calcineurin-regulated NFAT-dependent transcription in lymphocytes - (Pathway Interaction Database NCI-Nature Curated)
- Regulation of retinoblastoma protein - (Pathway Interaction Database NCI-Nature Curated)
- RXR and RAR heterodimerization with other nuclear receptor - (Pathway Interaction Database NCI-Nature Curated)
- Signaling events mediated by HDAC Class I - (Pathway Interaction Database NCI-Nature Curated)
†
External pathways not curated by PharmGKB.
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug Class | Relationship | Evidence | |
|---|---|---|---|
|
hmg coa reductase inhibitors |
|
Publications |
|
|
thiazolidinediones |
|
Publications |
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
|
aspirin |
|
Publications |
|
|
celecoxib |
|
Publications |
|
|
insulin-glargine |
|
Publications |
|
|
pioglitazone |
|
Publications |
|
|
rosiglitazone |
|
Publications |
|
|
torcetrapib |
|
Publications |
|
|
troglitazone |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this gene.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Acquired partial lipodystrophy |
|
Publications |
|
|
Arthritis, Psoriatic |
|
Variants |
|
|
Asthma |
|
Publications |
|
|
Cardiovascular Diseases |
|
Publications |
|
|
Diabetes Mellitus |
|
Publications |
|
|
diabetes mellitus type 2 and obesity |
|
Publications |
|
|
Diabetes Mellitus, Type 2 |
|
Publications, Variants |
|
|
Endometrial Neoplasms |
|
Publications |
|
|
Hypertension |
|
Publications |
|
|
Lipodystrophy |
|
Publications |
|
|
Liver Neoplasms |
|
Publications |
|
|
Obesity |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
Downloads
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LinkOuts
- Entrez Gene ID:
- 5468
- OMIM Accession:
- 125853
- 137800
- 151660
- 601487
- 601665
- 604367
- 609338
- UCSC Genome Browser ID:
- NM_005037
- Ref Seq NM Accession:
- NM_005037
- NM_015869
- NM_138711
- NM_138712
- Ref Seq NP Accession:
- AAB04028
- AAC51248
- AAH06811
- AAN38992
- AAP35945
- ABC97372
- ABM82034
- ABM85215
- BAA18949
- BAA23353
- BAA23354
- BAD20647
- BAD34540
- BAD97248
- BAF83270
- BAG70151
- BAG70300
- BAH02283
- CAA62152
- CAA62153
- CAD91388
- CAD91389
- CAG29019
- EAW64123
- EAW64124
- EAW64125
- NP_005028
- NP_056953
- NP_619725
- NP_619726
- P37231
- Q0QJH8
- Q4W448
- Q4W4C6
- Q4W4C7
- Q53EW1
- Q6L9M1
- Q86WD1
- Q9UEF6
- Ref Seq NT Accession:
- AC_000046
- AC_000135
- NC_000003
- NG_011749
- NT_022517
- NW_001838877
- NW_921651
- UniProtKB Accesssion:
- PPARG_HUMAN (P37231)
- Ensembl ID:
- ENSG00000132170
- GenAtlas ID:
- PPARG
- GeneCard ID:
- PPARG
- SOURCE ID:
- PPARG
- MutDB ID:
- PPARG
- PromoLign ID:
- ortho_1750
- ALFRED ID:
- LO000312G
- HuGE ID:
- PPARG
- Comparative Toxicogenomics Acc ID:
- 5468
- ModBase:
- Q15832
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.