PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
FDPS
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)

Overview

Alternate Names: FPP synthetase; OTTHUMP00000015807; OTTHUMP00000015808; farnesyl diphosphate synthase
Alternate Symbols: FPPS; FPS
PharmGKB Accession Id: PA28075

Details

Cytogenetic Location: chr1 : q22
GP mRNA Boundary†: chr1 : 153545374 - 153557080
GP Gene Boundary†: chr1 : 153535374 - 153560080
Strand: plus
Product Name: farnesyl diphosphate synthase, farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Curated Annotations (Curated Annotation)

  1. rs2297480 at chr1:153546106 in FDPS, PKLR
    This variant impacted the response to long-term N-bisphosphonates treatment in a study of 234 Danish postmenopausal women. Patients with the homozygous CC genotype showed a decreased response of bone turnover markers to amino-bisphosphonate therapy.
    Related Drugs:
    alendronate, ibandronate, pamidronate, risedronate, zoledronate
    Related Diseases:
    Osteoporosis, Osteoporosis, Postmenopausal
    Evidence:
    PMID:18687167
Variant names are different names that have been used in the literature and other resources to refer to the same variant.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
alendronate
  • CO
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
ibandronate
  • CO
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
pamidronate
  • CO
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
risedronate
  • CO
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
zoledronate
  • CO
  •   
  •   
  •   
  • GN
Publications, Variants

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Hypercalcemia
  •   
  •   
  •   
  •   
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Osteogenesis Imperfecta
  •   
  •   
  •   
  •   
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Osteoporosis
  • CO
  •   
  •   
  •   
  • GN
Publications, Variants
No phenotype data No genotype data Literature annotations available Not annotated
Osteoporosis, Postmenopausal
  • CO
  •   
  •   
  •   
  • GN
Publications, Variants

LinkOuts

Entrez Gene ID:
2224
OMIM Accession:
134629
UCSC Genome Browser ID:
NM_002004
Ref Seq NM Accession:
NM_001135821
NM_001135822
NM_002004
Ref Seq NP Accession:
AAA35820
AAA52423
AAH10004
ABM84397
ABM86869
BAA03523
BAF83773
BAG51125
CAI12715
EAW53075
EAW53076
EAW53077
EAW53078
NP_001129293
NP_001129294
NP_001995
P14324
Ref Seq NT Accession:
AC_000044
AC_000133
NC_000001
NT_004487
NW_001838531
NW_925683
UniProtKB Accesssion:
FPPS_HUMAN (P14324)
Ensembl ID:
ENSG00000160752
GenAtlas ID:
FDPS
GeneCard ID:
FDPS
SOURCE ID:
FDPS
MutDB ID:
FDPS
PromoLign ID:
ortho_272
HuGE ID:
FDPS
Comparative Toxicogenomics Acc ID:
2224
ModBase:
P14324

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

PharmGKB® is a registered trademark of HHS and is financially supported by NIH/NIGMS. It is managed at Stanford University (GM61374).
©2001-2010 PharmGKB.