Overview
| Alternate Names: | D(2C) dopamine receptor; seven transmembrane helix receptor |
|---|---|
| Alternate Symbols: | D4DR |
| PharmGKB Accession Id: | PA27480 |
Details
| Cytogenetic Location: | chr11 : p15.5 |
|---|---|
| GP mRNA Boundary†: | chr11 : 627305 - 630703 |
| GP Gene Boundary†: | chr11 : 617305 - 633703 |
| Strand: | plus |
| Product Name: | D(2C) dopamine receptor, dopamine receptor D4, see also Acc#: L12398, seven transmembrane helix receptor |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
Curated Annotations (
)
-
rs3758653
at chr11:626399
in
DRD4,
SCT
This variant along with 3 other SNPs near DRD4 (4 SNP haplotype: rs3758653; rs916457; rs762502; rs11246226) is associated with tardive dyskinesia in male schizophrenia patients.- Related Diseases:
- Schizophrenia, tardive dyskinesia
- Evidence:
-
PMID:19238168
-
rs916457
at chr11:627014
in
DRD4,
SCT
This variant along with 3 other SNPs near DRD4 (4 SNP haplotype: rs3758653; rs916457; rs762502; rs11246226) is associated with tardive dyskinesia in male schizophrenia patients.- Related Diseases:
- Schizophrenia, tardive dyskinesia
- Evidence:
-
PMID:19238168
-
rs762502
at chr11:630119
in
DRD4
This variant in exon 3 of DRD4 along with 3 other SNPs near DRD4 (4 SNP haplotype: rs3758653; rs916457; rs762502; rs11246226) is associated with tardive dyskinesia in male schizophrenia patients.- Variant Name:
- DRD4:Cys290Cys; T870C
- Related Diseases:
- Schizophrenia, tardive dyskinesia
- Evidence:
-
PMID:19238168
-
rs11246226
at chr11:631191
in
DRD4
This variant along with 3 other SNPs near DRD4 (4 SNP haplotype: rs3758653; rs916457; rs762502; rs11246226) is associated with tardive dyskinesia in male schizophrenia patients.- Related Diseases:
- Schizophrenia, tardive dyskinesia
- Evidence:
-
PMID:19238168
Variant names are different names that have been used in the literature and other resources to
refer to the same variant.
Non-Curated Information
A list of non-curated publications that mention this gene along with other genes is available.
PharmGKB Curated Pathways
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug Class | Relationship | Evidence | |
|---|---|---|---|
|
antipsychotics |
|
Publications |
|
|
thioxanthene derivatives |
|
Publications |
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
|
amisulpride |
|
Publications |
|
|
clozapine |
|
Publications |
|
|
fluspirilene |
|
Publications |
|
haloperidol |
|
Publications |
|
|
methylphenidate |
|
Publications |
|
|
nicotine |
|
Publications, Pathways |
|
|
olanzapine |
|
Publications |
|
|
perazine |
|
Publications |
|
|
quetiapine |
|
Publications |
|
|
risperidone |
|
Publications |
|
|
ziprasidone |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this gene.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Attention Deficit Disorder with Hyperactivity |
|
Publications |
|
|
Body Weight Changes |
|
Publications |
|
|
Personality Disorders |
|
Publications |
|
|
Psychotic Disorders |
|
Publications |
|
|
Schizophrenia |
|
Publications, Variants |
|
|
tardive dyskinesia |
|
Publications, Variants |
|
|
Tobacco Use Disorder |
|
Publications, Pathways |
Non-Curated Information
A list of non-curated publications that mention this gene along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
LinkOuts
- Entrez Gene ID:
- 1815
- OMIM Accession:
- 126452
- 143465
- 168600
- 601696
- UCSC Genome Browser ID:
- NM_000797
- Ref Seq NM Accession:
- NM_000797
- Ref Seq NP Accession:
- AAB33728
- AAB46802
- AAB46803
- AAB59386
- AAI72267
- AAL35159
- AAL35160
- AAL35161
- AAL35162
- AAL35163
- AAL35164
- AAL35165
- AAL35166
- AAL35167
- AAL35168
- AAL35169
- AAL35170
- AAL35171
- AAL35172
- AAL35173
- AAL35174
- AAL35175
- AAL35176
- AAL35177
- AAL35178
- AAL35179
- AAL35180
- AAL35181
- AAL35182
- AAL35183
- AAL35184
- AAL35185
- AAL35186
- AAL35187
- AAL35188
- AAL35189
- AAL35190
- AAL35191
- AAL35192
- AAL35193
- AAL35194
- AAL35195
- AAL35196
- AAL35197
- AAL35198
- AAL35199
- AAL35200
- AAL35201
- AAL35202
- AAL35203
- AAL35204
- AAL35205
- AAL35206
- AAL35207
- AAL35208
- AAL35209
- AAL35210
- AAL35211
- AAL35212
- AAL35213
- AAL58637
- AAN73253
- AAN73255
- AAN73256
- AAN73257
- AAN73258
- AAN73259
- AAN73260
- AAN73261
- AAN73262
- AAN73263
- AAN73264
- ABY87911
- BAC05985
- BAD00718
- BAD00719
- BAD00720
- EAX02369
- NP_000788
- P21917
- Q0MTB8
- Q16303
- Q76E76
- Q8IZB1
- Q8IZB2
- Q8IZB3
- Q8IZB4
- Q8IZB5
- Q8IZB6
- Q8IZB7
- Q8IZB8
- Q8IZC0
- Q8NGM5
- Q8WTQ0
- Q8WTQ5
- Q8WTR3
- Q8WTR5
- Q8WTR9
- Q8WTS5
- Q8WTS7
- Q8WTT3
- Q8WTT6
- Q8WTT7
- Q8WXL5
- Q8WXL6
- Q8WXL7
- Q8WXL8
- Q8WXL9
- Q8WXM0
- Q8WXM1
- Q8WXM3
- Q8WXM4
- Q8WXM5
- Q8WXM6
- Q8WXM7
- Q8WXM8
- Q8WXM9
- Q8WXN0
- Q8WXN1
- Q8WXN2
- Q8WXN3
- Q8WXN4
- Q8WXN5
- Q8WXN6
- Q8WXN7
- Q8WXN8
- Q8WXN9
- Q8WXP0
- Q8WXP1
- Q8WXP2
- Q8WXP3
- Q8WXP4
- Q8WXP5
- Q8WXP6
- Q8WXP7
- Q99586
- Q99587
- Ref Seq NT Accession:
- AC_000054
- AC_000143
- NC_000011
- NT_035113
- NW_001838016
- NW_924962
- UniProtKB Accesssion:
- DRD4_HUMAN (P21917)
- Ensembl ID:
- ENSG00000069696
- GenAtlas ID:
- DRD4
- GeneCard ID:
- DRD4
- SOURCE ID:
- DRD4
- MutDB ID:
- DRD4
- PromoLign ID:
- ortho_4616
- ALFRED ID:
- LO000227L
- HuGE ID:
- DRD4
- Comparative Toxicogenomics Acc ID:
- 1815
- ModBase:
- P21917
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.