Gene:
ABCB4
ATP-binding cassette, sub-family B (MDR/TAP), member 4

Overview

Alternate Names: ATP-binding cassette, subfamily B, member 4; Human membrane glycoprotein P (mdr3) mRNA, complete cds.; OTTHUMP00000025014; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein-3/multiple drug resistance-3; multidrug resistance protein 3; multiple drug resistance 3
Alternate Symbols: ABC21; ABCB4; GBD1; M23234.1; MDR2; MDR2/3; MDR3; PFIC-3; PGY3
PharmGKB Accession Id: PA268

Details

Cytogenetic Location: chr7 : q21.12
GP mRNA Boundary: chr7 : 86869297 - 86947684
GP Gene Boundary: chr7 : 86866297 - 86957684
Strand: minus
Product Name: ATP-binding cassette, subfamily B, member 4, ATP-binding cassette, subfamily B, member 4 isoform A, ATP-binding cassette, subfamily B, member 4 isoform B, ATP-binding cassette, subfamily B, member 4 isoform C, P glycoprotein 3/multiple drug resistance 3, multidrug resistance protein 3, multiple drug resistance 3
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

BioCarta Pathways

External pathways not curated by PharmGKB.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
vinca alkaloids and analogues
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  • PK
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Pathways
  Drug Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
azidothymidine
  •   
  • PD
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
doxorubicin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
tacrine
  •   
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
vinblastine
  •   
  •   
  • PK
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
vincristine
  •   
  •   
  • PK
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  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
vindesine
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  •   
  • PK
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
vinorelbine
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  •   
  • PK
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  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Alzheimer Disease
  •   
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Cholestasis
  •   
  • PD
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Hodgkin Disease
  •   
  •   
  • PK
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Lymphoma, Non-Hodgkin
  •   
  •   
  • PK
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Multiple Myeloma
  •   
  •   
  • PK
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Precursor Cell Lymphoblastic Leukemia-Lymphoma
  •   
  •   
  • PK
  •   
  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. Effects of Pravastatin on Mouse Liver

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LinkOuts

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
©2001-2010 PharmGKB.