PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
ABCB4
ATP-binding cassette, sub-family B (MDR/TAP), member 4

Overview

Alternate Names: ATP-binding cassette, subfamily B, member 4; Human membrane glycoprotein P (mdr3) mRNA, complete cds.; OTTHUMP00000025014; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein-3/multiple drug resistance-3; multidrug resistance protein 3; multiple drug resistance 3
Alternate Symbols: ABC21; ABCB4; GBD1; M23234.1; MDR2; MDR2/3; MDR3; PFIC-3; PGY3
PharmGKB Accession Id: PA268

Details

Cytogenetic Location: chr7 : q21.12
GP mRNA Boundary†: chr7 : 86869297 - 86947684
GP Gene Boundary†: chr7 : 86866297 - 86957684
Strand: minus
Product Name: ATP-binding cassette, subfamily B, member 4, ATP-binding cassette, subfamily B, member 4 isoform A, ATP-binding cassette, subfamily B, member 4 isoform B, ATP-binding cassette, subfamily B, member 4 isoform C, P glycoprotein 3/multiple drug resistance 3, multidrug resistance protein 3, multiple drug resistance 3
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

BioCarta Pathways†

† External pathways not curated by PharmGKB.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
vinca alkaloids and analogues
  •   
  •   
  • PK
  •   
  •   
Pathways
  Drug Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
azidothymidine
  •   
  • PD
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
doxorubicin
  •   
  •   
  •   
  • FA
  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
tacrine
  •   
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
vinblastine
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
vincristine
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
vindesine
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
vinorelbine
  •   
  •   
  • PK
  •   
  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Alzheimer Disease
  •   
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Cholestasis
  •   
  • PD
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Hodgkin Disease
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Lymphoma, Non-Hodgkin
  •   
  •   
  • PK
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
Multiple Myeloma
  •   
  •   
  • PK
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Precursor Cell Lymphoblastic Leukemia-Lymphoma
  •   
  •   
  • PK
  •   
  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. Effects of Pravastatin on Mouse Liver

Downloads

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LinkOuts

Entrez Gene ID:
5244
OMIM Accession:
147480
171060
600803
602347
UCSC Genome Browser ID:
NM_000443
Ref Seq NM Accession:
NM_000443
NM_018849
NM_018850
Ref Seq NP Accession:
AAA36207
AAD05023
AAH20618
AAH42531
ABJ53424
CAA29547
CAA84542
CAA84543
EAL24174
EAL24175
EAL24176
EAW76944
EAW76945
EAW76946
EAW76947
EAW76948
EAW76949
EAW76950
EAW76951
EAW76952
NP_000434
NP_061337
NP_061338
O43249
P21439
Q4G0Q4
Q6PJ81
Q75MQ5
Ref Seq NT Accession:
AC_000050
AC_000068
AC_000139
NC_000007
NG_007118
NT_007933
NT_079595
NW_001839064
NW_923574
UniProtKB Accesssion:
MDR3_HUMAN (P21439)
Ensembl ID:
ENSG00000005471
GenAtlas ID:
ABCB4
GeneCard ID:
ABCB4
SOURCE ID:
ABCB4
MutDB ID:
ABCB4
PromoLign ID:
ortho_3173
HuGE ID:
ABCB4
Comparative Toxicogenomics Acc ID:
5244
ModBase:
P21439

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
©2001-2010 PharmGKB.