Overview
| Alternate Names: | ATP-binding cassette, sub-family C, member 1; Human multidrug resistance-associated protein (MRP) mRNA, complete cds.; LTC4 transporter; OTTHUMP00000045904; leukotriene C(4) transporter; multidrug resistance protein; multiple drug resistance protein 1; multiple drug resistance-associated protein |
|---|---|
| Alternate Symbols: | ABC29; ABCC; DKFZp686N04233; DKFZp781G125; GS-X; L05628.1; MRP; MRP1 |
| PharmGKB Accession Id: | PA244 |
Details
| Cytogenetic Location: | chr16 : p13.11 |
|---|---|
| GP mRNA Boundary†: | chr16 : 15950935 - 16143774 |
| GP Gene Boundary†: | chr16 : 15940935 - 16146774 |
| Strand: | plus |
| Product Name: | ATP-binding cassette, sub-family C, member 1, ATP-binding cassette, sub-family C, member 1 isoform 1, ATP-binding cassette, sub-family C, member 1 isoform 2, ATP-binding cassette, sub-family C, member 1 isoform 3, ATP-binding cassette, sub-family C, member 1 isoform 4, ATP-binding cassette, sub-family C, member 1 isoform 5, ATP-binding cassette, sub-family C, member 1 isoform 6, ATP-binding cassette, sub-family C, member 1 isoform 7, multidrug resistance protein, multiple drug resistance protein 1, multiple drug resistance-associated protein |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
Curated Annotations (
)
-
rs119774
at chr16:15994334
in
ABCC1
Associations were found between genotypes of SNPs in the ALOX5 (rs2115819) and MRP1 (rs119774) genes and changes in FEV(1) (p < 0.05) in asthma patients treated with montelukast.- Variant Name:
- MRP1 (rs119774)
- Related Drugs:
- montelukast
- Related Diseases:
- Asthma
- Evidence:
-
PMID:16293801
-
rs3784862
at chr16:16018392
in
ABCC1
SNP is associated with the onset of toxicity to methotrexate in patients with psoriasis.- Related Drugs:
- methotrexate
- Related Diseases:
- Psoriasis
- Evidence:
-
PMID:18256692
-
rs246240
at chr16:16026525
in
ABCC1
SNP is associated with the onset of toxicity to methotrexate in patients with psoriasis.- Related Drugs:
- methotrexate
- Related Diseases:
- Psoriasis
- Evidence:
-
PMID:18256692
-
rs246240
at chr16:16026525
in
ABCC1
SNP is associated with development of hepatic or gastrointestinal toxicity to methotrexate in patients with psoriasis.- Related Drugs:
- methotrexate
- Evidence:
-
PMID:18256692
-
rs35592
at chr16:16049324
in
ABCC1
SNP influences the efficacy of methotrexate in patients with psoriasis.- Related Drugs:
- methotrexate
- Evidence:
-
PMID:18256692
-
rs35621
at chr16:16076109
in
ABCC1
This SNP in intron 14 of the ABCC1 gene was significantly associated with a highly excessive forced expiratory volume in 1s (FEV1) decline in Doetinchem (n = 1152) and Vlagtwedde-Vlaardingen (n = 1390) cohorts.- Related Diseases:
- Pulmonary Disease, Chronic Obstructive
- Evidence:
-
PMID:19687781
-
rs45511401
at chr16:16080733
in
ABCC1
Risk or phenotype-associated allele: 2012GT (671Gly/Val) genotype. Phenotype: Carriers the heterozygous 2012GT (671Gly/Val) genotype had lower serum HDL cholesterol than the GG (671Gly/Gly) genotype carriers (p = 0.015). Study size: 136. Study population/ethnicity: Hypercholesterolemic individuals, treated with atorvastatin (10mg/day/4 weeks), evaluated for CAD risk factors at the Institute Dante Pazzanese of Cardiology and the Hospital of the Sao Paulo University in Sao Paulo City, Brazil. Significance metric(s): p = 0.015. Type of association: GN; PD; FA- Variant Name:
- ABCC1:2012G>T, mRNA 2187G>T, Gly671Val
- Related Drugs:
- atorvastatin
- Related Diseases:
- Coronary Artery Disease, Hypercholesterolemia
- Evidence:
-
PMID:18851956
-
rs45511401
at chr16:16080733
in
ABCC1
system: membrane vessicles from HEK cells transfected with WT and variant; FA: transport of leukotriene C4, 17beta-estradiol 17beta-(D)-glucuronide, and estrone sulfate were the same for WT and variant- Variant Name:
- G671V
- Related Drugs:
- estradiol, estrone
- Evidence:
-
PMID:11721885
-
rs45511401
at chr16:16080733
in
ABCC1
Risk or phenotype-associated allele: T. Phenotype: This SNP was associated with acute cardiotoxicity in response to doxorubicin. Study size: 1697. Study population/ethnicity: Participants of the German non-Hodgkin lymphoma study. Significance metric(s): OR = 3.6; 95% CI, 1.6 to 8.4. Type of association: PD; ADR; TOX.- Variant Name:
- MRP1 Gly671Val; ABCC1 rs45511401
- Related Drugs:
- doxorubicin
- Related Diseases:
- Arrhythmias, Cardiac, Cardiomyopathies, Drug Toxicity, Lymphoma, Non-Hodgkin
- Evidence:
-
PMID:16330681
-
rs4148356
at chr16:16084776
in
ABCC1
system: membrane vessicles from HEK cells transfected with WT or variant; FA: variant had approx 50% decrease in transport of tritium labelled 17[beta]-estradiol-17[beta]-D-glucuronide and tritium labelled methotrexate- Variant Name:
- Arg723Gln
- Related Drugs:
- methotrexate
- Evidence:
-
PMID:16041243
-
rs35529209
at chr16:16112826
in
ABCC1
system: membrane vessicles from HEK cells transfected with WT or variant; FA: variant had approx 50% decrease in transport of tritium labelled 17[beta]-estradiol-17[beta]-D-glucuronide (17E2b-g) due to decrease in Km- Variant Name:
- Ala989Thr
- Related Drugs:
- estradiol
- Evidence:
-
PMID:16041243
-
rs2238476
at chr16:16121373
in
ABCC1
SNP influences the efficacy of methotrexate in patients with psoriasis.- Related Drugs:
- methotrexate
- Evidence:
-
PMID:18256692
-
rs28364006
at chr16:16135750
in
ABCC1
SNP influences the efficacy of methotrexate in patients with psoriasis.- Related Drugs:
- methotrexate
- Related Diseases:
- Psoriasis
- Evidence:
-
PMID:18256692
-
rs212093
at chr16:16145255
in
ABCC1
This SNP in the 3' region of the ABCC1 gene was significantly associated with a lower forced expiratory volume in 1s in Doetinchem (n = 1152) and Vlagtwedde-Vlaardingen (n = 1390) cohorts.- Related Diseases:
- Pulmonary Disease, Chronic Obstructive
- Evidence:
-
PMID:19687781
-
rs4148382
at chr16:16145995
in
ABCC1
This SNP in the 3' region of the ABCC1 gene was significantly associated with a higher forced expiratory volume in 1s in Doetinchem (n = 1152) and Vlagtwedde-Vlaardingen (n = 1390) cohorts.- Related Diseases:
- Pulmonary Disease, Chronic Obstructive
- Evidence:
-
PMID:19687781
Non-Curated Annotations (
)
-
rs3765129
at chr16:16057402
in
ABCC1
Approximately 50% of the variation in absolute neutrophil count nadir in cancer patients is explained by rs3765129, rs2306283 and UGT1a1*93.- Variant Name:
- ABCC1: IVS11 ¿48C>T
- Related Diseases:
- Neoplasms
- Evidence:
-
PMID:19940846
-
rs35605
at chr16:16069520
in
ABCC1
The AUCs of irinotecan, SN-38, SN-38 glucuronide, and APC are influenced by rs3740066, rs2306283, rs35605, rs10276036, and rs717620 .- Variant Name:
- ABCC1: 1684C>T
- Related Drugs:
- irinotecan, SN-38
- Evidence:
-
PMID:19940846
Variant names are different names that have been used in the literature and other resources to
refer to the same variant.
Non-curated variant information is accumulated solely by computational methods and has not
been verified by the scientific staff at PharmGKB.
Non-Curated Information
A list of non-curated publications that mention this gene along with other genes is available.
PharmGKB Curated Pathways
- Doxorubicin (Cancer PD)
- Doxorubicin (PK)
- Etoposide Pathway
- Irinotecan Pathway (liver)
- Methotrexate Pathway
- Taxane Pathway
- Vinca Alkaloids Pathway (PK)
BioCarta Pathways†
PID Pathways†
- S1P1 pathway - (Pathway Interaction Database NCI-Nature Curated)
- Sphingosine 1-phosphate (S1P) pathway - (Pathway Interaction Database NCI-Nature Curated)
Reactome Pathways†
†
External pathways not curated by PharmGKB.
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug Class | Relationship | Evidence | |
|---|---|---|---|
|
anthracyclines and related substances |
|
Publications |
|
|
antineoplastic agents |
|
Publications |
|
|
estrogens |
|
Publications |
|
|
Imidazothiazole derivatives |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this gene.
Non-Curated Information
A list of non-curated publications that mention this gene along with other diseases is available.
Curated Phenotype Datasets
These datasets are sorted alphabetically by title.
- Outcomes in Asthmatics taking montelukast
- CO
- PD
Submitted by John Lima, PharmD involving ABCC1, ALOX5, CYSLTR1, LTA4H, LTC4S, montelukast, and Asthma - RNA expression in metabolite and transport genes
- FA
Submitted by Howard McLeod, PharmD involving ABCB1, ABCC1, ABCC2, ABCC3, ABCC4, ABCG2, ATM, ATR, BAK1, BAX, BCL2, BCL2L1, CCNA2, CCND1, CDA, CDC2, CDC25C, CDC37, CDC45L, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CES1, CES2, CYP3A4, CYP3A5, DCK, DDB1, DHFR, DPYD, DPYS, DRG1, DTYMK, DUT, E2F1, ECGF1, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, FASLG, FDXR, FPGS, GGH, GSTM1, GSTP1, HMGB1, MAP4, MLH1, MPO, MSH2, MSH6, MTHFR, NFKB1, NME1, NME2, NT5C, PARP1, POLB, POLH, PTGS1, PTGS2, RAD9A, RB1, RRM1, RRM2, SOD1, TDP1, TK1, TOP1, TOP2A, TP53, TUBB, TYMS, UCK2, UGT1A1, UMPS, UNG, UPB1, UPP1, XPA, XPC, XRCC1, and Colonic Neoplasms
Downloads
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LinkOuts
- Entrez Gene ID:
- 4363
- OMIM Accession:
- 158343
- UCSC Genome Browser ID:
- NM_004996
- Ref Seq NM Accession:
- NM_004996
- NM_019862
- NM_019898
- NM_019899
- NM_019900
- NM_019901
- NM_019902
- Ref Seq NP Accession:
- AAB46616
- AAB83979
- AAB83980
- AAB83981
- AAB83982
- AAB83983
- AAC05808
- AAC15784
- AAH01636
- AAI56354
- AAI57106
- BAD92357
- CAH18691
- EAW53936
- EAW53937
- EAW53938
- EAW53939
- EAW53940
- EAW53941
- EAW53942
- EAW53943
- EAW53944
- EAW53945
- EAW53946
- EAW53947
- EAW53948
- EAW53949
- NP_004987
- NP_063915
- NP_063953
- NP_063954
- NP_063955
- NP_063956
- NP_063957
- P33527
- Q68CP7
- Q9BV39
- Q9UQ98
- Ref Seq NT Accession:
- AC_000059
- AC_000148
- NC_000016
- NT_010393
- NW_001838356
- NW_926051
- Ensembl ID:
- ENSG00000103222
- GenAtlas ID:
- ABCC1
- GeneCard ID:
- ABCC1
- SOURCE ID:
- ABCC1
- MutDB ID:
- ABCC1
- PromoLign ID:
- ortho_6116
- HuGE ID:
- ABCC1
- Comparative Toxicogenomics Acc ID:
- 4363
- ModBase:
- P33527
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.