PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
ABCC8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8

Overview

Alternate Names: ATP-binding cassette, sub-family C, member 8; Sulfonylurea receptor; sulfonylurea receptor (hyperinsulinemia)
Alternate Symbols: ABC36; ABCC8; HHF1; HI; HRINS; MRP8; PHHI; SUR; SUR1; TNDM2
PharmGKB Accession Id: PA24395

Details

Cytogenetic Location: chr11 : p15.1
GP mRNA Boundary†: chr11 : 17371009 - 17455025
GP Gene Boundary†: chr11 : 17368009 - 17465025
Strand: minus
Product Name: ATP-binding cassette, sub-family C, member 8, sulfonylurea receptor (hyperinsulinemia)
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
sulfonamides, urea derivatives
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  • GN
Publications
  Drug Relationship Evidence
Phenotype data available No genotype data Literature annotations available Not annotated
cisplatin
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
diazoxide
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  •   
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  • FA
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Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
docetaxel
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  •   
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  • FA
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Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
gemcitabine
  •   
  •   
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
glibenclamide
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  • PD
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
gliclazide
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  • PD
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  •   
Publications
No phenotype data No genotype data Literature annotations available Not annotated
glimepiride
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  • PD
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
tolbutamide
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  • PD
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Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Carcinoma, Non-Small-Cell Lung
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  • FA
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Publications
No phenotype data No genotype data Literature annotations available Not annotated
Diabetes Mellitus
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  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Diabetes Mellitus, Type 2
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  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Diabetes, Permanent Neonatal (PNDM)
  • CO
  •   
  •   
  • FA
  • GN
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. A chemogenomic approach to drug discovery: focus on cardiovascular diseases
  2. Adaptations to Climate in Candidate Genes for Common Metabolic Disorders

Downloads

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LinkOuts

Entrez Gene ID:
6833
OMIM Accession:
125853
240800
256450
600509
606176
610374
UCSC Genome Browser ID:
NM_000352
Ref Seq NM Accession:
NM_000352
Ref Seq NP Accession:
AAA99227
AAB02278
AAB02417
AAB02418
AAB36699
AAB36700
AAC36724
AAI67829
BAD92321
BAH12616
EAW68436
EAW68437
NP_000343
Q09428
Q59GM5
Ref Seq NT Accession:
AC_000054
AC_000143
NC_000011
NG_008867
NT_009237
NW_001838022
NW_925006
UniProtKB Accesssion:
ABCC8_HUMAN (Q09428)
Ensembl ID:
ENSG00000006071
GenAtlas ID:
ABCC8
GeneCard ID:
ABCC8
SOURCE ID:
ABCC8
MutDB ID:
ABCC8
PromoLign ID:
ortho_4481
ALFRED ID:
LO002483R
HuGE ID:
ABCC8
Comparative Toxicogenomics Acc ID:
6833

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

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