Overview
| Alternate Names: | OTTHUMP00000023165 |
|---|---|
| Alternate Symbols: | None |
| PharmGKB Accession Id: | PA236 |
Details
| Cytogenetic Location: | chrX : p11.3 |
|---|---|
| GP mRNA Boundary†: | chrX : 43400353 - 43491012 |
| GP Gene Boundary†: | chrX : 43390353 - 43494012 |
| Strand: | plus |
| Product Name: | monoamine oxidase A |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
Non-Curated Annotations (
)
-
rs3027409
at chrX:43491977
in
MAOA
GWAS results: Genome-wide and candidate gene association study of cigarette Smoking behaviors. (Initial Sample Size: 4,611 individuals (2,617 smokers); Replication Sample Size: NR); (Region: Xp11.3; Reported Gene(s): MAOA; Risk Allele: rs3027409-?); (p-value= 0.000007).This variant is associated with Smoking behaviors.- Related Diseases:
- Tobacco Use Disorder
- Evidence:
-
PMID:19247474
http://www.genome.gov/gwastudies/
Variant names are different names that have been used in the literature and other resources to
refer to the same variant.
Non-curated variant information is accumulated solely by computational methods and has not
been verified by the scientific staff at PharmGKB.
Non-Curated Information
A list of non-curated publications that mention this gene along with other genes is available.
PharmGKB Curated Pathways
Reactome Pathways†
- Enzymatic degradation of dopamine by COMT - (Reactome via Pathway Interaction Database)
- Enzymatic degradation of Dopamine by monoamine oxidase - (Reactome via Pathway Interaction Database)
- Metabolism of serotonin - (Reactome via Pathway Interaction Database)
- Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2 - (Reactome via Pathway Interaction Database)
- Norepinephrine Neurotransmitter Release Cycle - (Reactome via Pathway Interaction Database)
†
External pathways not curated by PharmGKB.
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug Class | Relationship | Evidence | |
|---|---|---|---|
|
antidepressants |
|
Publications |
|
|
antipsychotics |
|
Publications |
|
|
Monoamine oxidase A inhibitors |
|
Publications |
|
|
Selective serotonin reuptake inhibitors |
|
Publications |
| Drug | Relationship | Evidence | |
|---|---|---|---|
|
|
citalopram |
|
Publications, Pathways |
|
fluoxetine |
|
Publications, Pathways |
|
|
fluvoxamine |
|
Publications |
|
nicotine |
|
Publications |
|
|
paroxetine |
|
Publications, Pathways |
|
|
risperidone |
|
Publications |
|
|
sertraline |
|
Publications, Pathways |
Non-Curated Information
A list of non-curated publications that mention this gene along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this gene.
| Disease | Relationship | Evidence | |
|---|---|---|---|
|
|
Bipolar Disorder |
|
Publications |
|
|
Bulimia |
|
Pathways |
|
|
Depression |
|
Publications, Pathways |
|
|
Depressive Disorder |
|
Publications |
|
|
Depressive Disorder, Major |
|
Publications |
|
|
Dyskinesia, Drug-Induced |
|
Publications |
|
|
Dystonia |
|
Publications |
|
|
Hypokinesia |
|
Publications |
|
|
Muscle Rigidity |
|
Publications |
|
|
Obsessive-Compulsive Disorder |
|
Pathways |
|
|
Schizophrenia |
|
Publications |
|
|
Tobacco Use Disorder |
|
Publications |
|
|
Tremor |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other diseases is available.
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
Downloads
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LinkOuts
- Entrez Gene ID:
- 4128
- OMIM Accession:
- 300615
- 309850
- UCSC Genome Browser ID:
- NM_000240
- Ref Seq NM Accession:
- NM_000240
- Ref Seq NP Accession:
- AAA59547
- AAA59548
- AAA59549
- AAB46385
- AAD14113
- AAD14361
- AAH08064
- AAH44787
- AAP35297
- AAV34705
- AAV34711
- AAV34717
- AAV34720
- ABM81602
- ABM84783
- BAD97219
- BAF84458
- BAG57307
- CAI42421
- CAI42424
- CAI43216
- EAW59381
- EAW59382
- EAW59383
- NP_000231
- P21397
- Q49A63
- Q53EZ0
- Q5UL91
- Q5UL94
- Q5ULA3
- Q5ULA9
- Ref Seq NT Accession:
- AC_000066
- AC_000155
- NC_000023
- NG_008957
- NT_079573
- NW_001842361
- NW_927701
- UniProtKB Accesssion:
- AOFA_HUMAN (P21397)
- Ensembl ID:
- ENSG00000189221
- GenAtlas ID:
- MAOA
- GeneCard ID:
- MAOA
- SOURCE ID:
- MAOA
- MutDB ID:
- MAOA
- PromoLign ID:
- ortho_8377
- ALFRED ID:
- LO005929Z
- HuGE ID:
- MAOA
- Comparative Toxicogenomics Acc ID:
- 4128
- ModBase:
- P21397
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.