PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5

Overview

Alternate Names: G protein-activated inward rectifier potassium channel 4; cardiac ATP-sensitive potassium channel; cardiac inward rectifier; heart KATP channel; inward rectifier K+ channel KIR3.4; potassium inwardly-rectifying channel J5
Alternate Symbols: CIR; GIRK4; KATP1; KIR3.4; Kir3.4
PharmGKB Accession Id: PA216

Details

Cytogenetic Location: chr11 : q24.3
GP mRNA Boundary†: chr11 : 128266523 - 128293174
GP Gene Boundary†: chr11 : 128256523 - 128296174
Strand: plus
Product Name: G protein-activated inward rectifier potassium channel 4, cardiac ATP-sensitive potassium channel, cardiac inward rectifier, heart KATP channel, inward rectifier K+ channel KIR3.4, potassium inwardly-rectifying channel J5, potassium inwardly-rectifying channel, subfamily J, member 5
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
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  • PD
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  • FA
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Publications, Pathways
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
amiodarone
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
arsenic trioxide
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
cisapride
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
disopyramide
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
dofetilide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
droperidol
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
flecainide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
halofantrine
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
haloperidol
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
ibutilide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
lidocaine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mesoridazine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
methadone
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mexiletine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pentamidine
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pimozide
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
procainamide
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
propafenone
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
quinidine
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
sotalol
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  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
sparfloxacin
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  • PD
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Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
thioridazine
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  • PD
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Pathways
No phenotype data No genotype data No literature annotations Not annotated
tocainide
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  • PD
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Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

LinkOuts

Entrez Gene ID:
3762
OMIM Accession:
600734
UCSC Genome Browser ID:
NM_000890
Ref Seq NM Accession:
NM_000890
Ref Seq NP Accession:
AAB07269
AAB53093
AAH69386
AAH69482
AAH69499
AAH69571
AAH74838
AAH74839
AAH96834
BAA08814
BAG35691
CAA58565
EAW67726
EAW67727
NP_000881
P48544
Q4QRJ2
Ref Seq NT Accession:
AC_000054
AC_000143
NC_000011
NT_033899
NW_001838044
NW_925173
UniProtKB Accesssion:
IRK5_HUMAN (P48544)
Ensembl ID:
ENSG00000120457
GenAtlas ID:
KCNJ5
GeneCard ID:
KCNJ5
SOURCE ID:
KCNJ5
MutDB ID:
KCNJ5
PromoLign ID:
ortho_4726
HuGE ID:
KCNJ5
Comparative Toxicogenomics Acc ID:
3762
ModBase:
P48544

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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