PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3

Overview

Alternate Names: G protein-activated inward rectifier potassium channel 1; inward rectifier K+ channel KIR3.1; potassium inwardly-rectifying channel J3
Alternate Symbols: GIRK1; KGA; KIR3.1; Kir3.1
PharmGKB Accession Id: PA215

Details

Cytogenetic Location: chr2 : q24.1
GP mRNA Boundary†: chr2 : 155263339 - 155421260
GP Gene Boundary†: chr2 : 155253339 - 155424260
Strand: plus
Product Name: G protein-activated inward rectifier potassium channel 1, inward rectifier K+ channel KIR3.1, potassium inwardly-rectifying channel J3, potassium inwardly-rectifying channel, subfamily J, member 3
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
  •   
  • PD
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  • FA
  • GN
Publications, Pathways
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
amiodarone
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  • PD
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Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
arsenic trioxide
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
cisapride
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
disopyramide
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
dofetilide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
droperidol
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
flecainide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
halofantrine
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
haloperidol
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
ibutilide
  •   
  • PD
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  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
lidocaine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mesoridazine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
methadone
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mexiletine
  •   
  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pentamidine
  •   
  • PD
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Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pimozide
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
procainamide
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
propafenone
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
quinidine
  •   
  • PD
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  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
sotalol
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
sparfloxacin
  •   
  • PD
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  •   
Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
thioridazine
  •   
  • PD
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  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
tocainide
  •   
  • PD
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  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

LinkOuts

Entrez Gene ID:
3760
OMIM Accession:
601534
UCSC Genome Browser ID:
NM_002239
Ref Seq NM Accession:
NM_002239
Ref Seq NP Accession:
AAB42176
AAH22495
AAX93197
ABM83289
ABM86498
BAG57228
BAG57305
EAX11461
NP_002230
P48549
Q53R59
Ref Seq NT Accession:
AC_000045
AC_000134
NC_000002
NT_005403
NW_001838860
NW_921585
UniProtKB Accesssion:
IRK3_HUMAN (P48549)
Ensembl ID:
ENSG00000162989
GenAtlas ID:
KCNJ3
GeneCard ID:
KCNJ3
SOURCE ID:
KCNJ3
MutDB ID:
KCNJ3
PromoLign ID:
ortho_1137
HuGE ID:
KCNJ3
Comparative Toxicogenomics Acc ID:
3760
ModBase:
P48549

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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