PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2

Overview

Alternate Names: cardiac inward rectifier potassium channel; inward rectifier K+ channel KIR2.1; inward rectifier potassium channel 2; potassium inwardly-rectifying channel J2
Alternate Symbols: HHBIRK1; HHIRK1; IRK1; KIR2.1; Kir2.1; LQT7; SQT3
PharmGKB Accession Id: PA214

Details

Cytogenetic Location: chr17 : q24.3
GP mRNA Boundary†: chr17 : 65677271 - 65687780
GP Gene Boundary†: chr17 : 65667271 - 65690780
Strand: plus
Product Name: cardiac inward rectifier potassium channel, inward rectifier K+ channel KIR2.1, inward rectifier potassium channel 2, potassium inwardly-rectifying channel J2, potassium inwardly-rectifying channel, subfamily J, member 2
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
  •   
  • PD
  •   
  • FA
  • GN
Publications, Pathways
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
amiodarone
  •   
  • PD
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  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
arsenic trioxide
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
cisapride
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
disopyramide
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
dofetilide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
droperidol
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
flecainide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
halofantrine
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
haloperidol
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
ibutilide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
lidocaine
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mesoridazine
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
methadone
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
mexiletine
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pentamidine
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
pimozide
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
procainamide
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
propafenone
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
quinidine
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available Genotype Data Available Literature annotations available Not annotated
sotalol
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data Literature annotations available Not annotated
sparfloxacin
  •   
  • PD
  •   
  •   
  •   
Pathways
Phenotype data available No genotype data Literature annotations available Not annotated
thioridazine
  •   
  • PD
  •   
  •   
  •   
Pathways
No phenotype data No genotype data No literature annotations Not annotated
tocainide
  •   
  • PD
  •   
  •   
  •   
Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. A chemogenomic approach to drug discovery: focus on cardiovascular diseases

LinkOuts

Entrez Gene ID:
3759
OMIM Accession:
170390
600681
609622
UCSC Genome Browser ID:
NM_000891
Ref Seq NM Accession:
NM_000891
Ref Seq NP Accession:
AAA64282
AAA91781
AAB50277
AAB88797
AAC39555
AAC50072
AAF73241
AAF73242
AAI52812
CAJ33689
EAW89092
NP_000882
P63252
Ref Seq NT Accession:
AC_000060
AC_000149
NC_000017
NG_008798
NT_010641
NW_001838454
NW_926918
UniProtKB Accesssion:
IRK2_HUMAN (P63252)
Ensembl ID:
ENSG00000123700
GenAtlas ID:
KCNJ2
GeneCard ID:
KCNJ2
SOURCE ID:
KCNJ2
MutDB ID:
KCNJ2
PromoLign ID:
ortho_6708
HuGE ID:
KCNJ2
Comparative Toxicogenomics Acc ID:
3759
ModBase:
P63252

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

The PharmGKB is financially supported by the NIH/ NIGMS and is managed at Stanford University (U01GM61374).
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