PharmGKB: The Pharmacogenomics Knowledge Base

Gene:
KCNA5
potassium voltage-gated channel, shaker-related subfamily, member 5

Overview

Alternate Names: cardiac potassium channel; insulinoma and islet potassium channel; potassium channel 1; potassium channel protein; voltage-gated potassium channel; voltage-gated potassium channel protein Kv1.5
Alternate Symbols: ATFB7; HCK1; HK2; HPCN1; KV1.5; Kv1.5; MGC117058; MGC117059; PCN1
PharmGKB Accession Id: PA208

Details

Cytogenetic Location: chr12 : p13.32
GP mRNA Boundary†: chr12 : 5023346 - 5026210
GP Gene Boundary†: chr12 : 5013346 - 5029210
Strand: plus
Product Name: cardiac potassium channel, insulinoma and islet potassium channel, potassium channel 1, potassium channel protein, potassium voltage-gated channel, shaker-related subfamily, member 5, voltage-gated potassium channel, voltage-gated potassium channel protein Kv1.5
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

Curated Information

The following drugs are in curated knowledge about this gene.

  Drug Class Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
antiarrhythmics, class i and iii
  •   
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Beta blocking agents, selective
  • CO
  •   
  •   
  •   
  • GN
Publications
  Drug Relationship Evidence
Phenotype data available Genotype Data Available Literature annotations available Not annotated
warfarin
  • CO
  •   
  •   
  •   
  • GN
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

  Disease Relationship Evidence
No phenotype data No genotype data Literature annotations available Not annotated
Arrhythmias, Cardiac
  • CO
  •   
  •   
  •   
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Atrial Fibrillation
  • CO
  •   
  •   
  • FA
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Brugada syndrome
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Cardiomyopathy, Hypertrophic
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Coronary Artery Disease
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Coronary Disease
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Death, Sudden, Cardiac
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Heart Diseases
  • CO
  •   
  •   
  •   
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Long QT Syndrome
  • CO
  •   
  •   
  •   
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Myocardial Infarction
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Sudden Infant Death
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Thromboembolism
  • CO
  •   
  •   
  •   
  • GN
Publications
Phenotype data available Genotype Data Available Literature annotations available Not annotated
Torsades de Pointes
  • CO
  •   
  •   
  •   
  • GN
Publications
No phenotype data No genotype data Literature annotations available Not annotated
Ventricular Fibrillation
  • CO
  •   
  •   
  •   
  • GN
Publications

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Curated Phenotype Datasets

These datasets are sorted alphabetically by title.

  1. KCNA5 variants in vitro
    • Genotype data available
    • Phenotype data available
    • No literature annotations
    • Not annotated
    • FA
    Submitted by Dan Roden, MD involving KCNA5, and quinidine

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

  1. A chemogenomic approach to drug discovery: focus on cardiovascular diseases

Downloads

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LinkOuts

Entrez Gene ID:
3741
OMIM Accession:
176267
612240
Ref Seq NM Accession:
NM_002234
Ref Seq NP Accession:
AAA36422
AAA60146
AAA61276
AAH96357
AAH96358
AAH99665
AAH99666
EAW88830
NP_002225
P22460
Q9UDA4
Ref Seq NT Accession:
AC_000055
AC_000144
NC_000012
NT_009759
NW_001838049
NW_925295
UniProtKB Accesssion:
KCNA5_HUMAN (P22460)
Ensembl ID:
ENSG00000130037
HuGE ID:
KCNA5
Comparative Toxicogenomics Acc ID:
3741
ModBase:
P22460
IUPHAR Receptor ID:
Kv1.5 (542)

Common Searches

Non-Curated Publications

A list of non-curated publications that mention this gene is available.

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