Gene:

HTR2A

5-hydroxytryptamine (serotonin) receptor 2A

Overview

Details

Curated Annotations ()

1. rs6314 at chr13:46307035 in HTR2A
   In a study in a unipolar depressive population (n=166) this variant showed an association with remission and response following paroxetine therapy. HTR2A C1354T heterozygotes were significantly associated with improved response to paroxetine therapy. The SNP was also studied as a modifier of antidepressant response in a study in depressed patients (n=173) given a variety of antidepressant treatments with no association found, however another report found the HTR2A T1354 allele to be associated with response to fluoxetine.

   Variant Name:

   HTR2A: C1354T

   Related Drugs:

   fluoxetine, paroxetine

   Related Diseases:

   Depression

   Evidence:

   PMID:11311507
   PMID:15052272
   PMID:18253134
   

2. rs6314 at chr13:46307035 in HTR2A
   This variant in the gene encoding the serotonin 2A receptor has been associated with human episodic memory performance and with differences in brain volume in memory-related brain regions.

   Variant Name:

   HTR2A: His452Tyr

   Evidence:

   PMID:14699448
   PMID:15891581
   PMID:18602445
   

3. rs7997012 at chr13:46309986 in HTR2A
   In one study, subjects homozygous for allele A had a reduction in absolute risk of having no response to treatment with citalopram for major depressive disorder. The allele was found to be more frequent in white than in black subjects, and this is consistant with racial differences in response to antidepressant treatment.

   Related Drugs:

   citalopram

   Related Diseases:

   Depressive Disorder, Major

   Evidence:

   PMID:16642436
   

4. rs7997012 at chr13:46309986 in HTR2A
   Risk or phenotype-associated allele: A. Phenotype: Patients with the 5-HTR2A intron 2 (rs7997012) AA genotype suffered from more pronounced side effects compared to carriers of the GA or GG genotype. Study size: 124. Study population/ethnicity: Caucasian; Patients with psychiatric disorders. Significance metric(s): p = 0.018 and p = 0.002. Type of association: PD.

   Variant Name:

   5-HTR2A intron 2 variant

   Related Drugs:

   olanzapine

   Evidence:

   PMID:19636338
   

5. rs9316233 at chr13:46331356 in HTR2A
   A sudy of 760 adult patients with moderate-to-severe depression, treated with escitalopram found that individuals carrying two minor alleles of rs9316233 variant in the HTR2A gene achieved an improvement that was on average 3.1 MADRS points more than individuals carrying two common alleles during escitalopram treatment. This explains 1.1% of variance (P=0.0016) of the response to escitalopram.

   Related Drugs:

   escitalopram

   Related Diseases:

   Depression

   Evidence:

   PMID:19365399
   

6. rs6313 at chr13:46367941 in HTR2A
   T allele is associated with olanzapine-induced weight gain

   Variant Name:

   HTR2A:T102C; HTR2A:102C>T

   Related Drugs:

   olanzapine

   Related Diseases:

   Weight gain

   Evidence:

   PMID:19193342
   

7. rs6313 at chr13:46367941 in HTR2A
   Risk or phenotype-associated allele (s): T/T. Phenotype: Patients, with a diagnosis of probable Alzheimer's disease, carrying the TT genotype were the most delusional during the follow-up period of a study evaluating the association of HTR2A 102T/C polymorphism with psychotic symptom severity. Patients with delusion symptoms carrying the CT and TT genotypes were resistant to the treatment with antipsychotic drugs. Study size: 80. Study population/ethnicity: Caucasian

   Variant Name:

   HTR2A:T102C; HTR2A:102C>T

   Related Drugs:

   olanzapine, risperidone

   Related Diseases:

   Alzheimer Disease

   Evidence:

   PMID:19494443
   

8. rs6311 at chr13:46369479 in HTR2A
   Associated with anorexia and bulimia. The AA genotype was found to be a risk factor for tardive dyskinesia (TD).

   Variant Name:

   HTR2A:-1438G>A

   Evidence:

   PMID:17688403
   PMID:17804117
   

9. rs6311 at chr13:46369479 in HTR2A
   The A allele of -1438G/A is suggested to have increased promoter activity in functional in vitro studies. In silico analysis revealed that the -1438 A allele creates a consensus binding site for Th1/E47, a transcription factor implicated in the development of the nervous system. The SNP was also associated with Chronic fatigue syndrome together with rs 6313 and rs1923884.

   Variant Name:

   HTR2A: -1438G/A

   Related Diseases:

   Depression

   Evidence:

   PMID:15364038
   PMID:18079067
   

10. rs6311 at chr13:46369479 in HTR2A
    Risk or phenotype-associated allele: A Phenotype: Carriers of the A variant of HTR2A:(-1438)G>A had lower Autism Treatment Evaluation Checklist (ATEC) scores than GG homozygotes, indicating improved symptoms and response to risperidone. Study size: 45 Study population/ethnicity: Children with Autism receiving risperidone Significance metric(s): p = 0.019 Type of association: PD

    Variant Name:

    HTR2A c.-1438G>A, HTR2A:(-1438)G>A

    Related Drugs:

    risperidone

    Related Diseases:

    Autistic Disorder

    Evidence:

    PMID:19997080
    

Non-Curated Information

A list of non-curated publications that mention this gene along with other genes is available.

PharmGKB Curated Pathways

• Selective Serotonin Reuptake Inhibitors (SSRI) Pathway

Curated Information

The following drugs are in curated knowledge about this gene.

	Drug Class	Relationship	Evidence
	antidepressants	PD       GN	Publications
	antipsychotics	CO PD    FA GN	Publications
	Selective serotonin reuptake inhibitors	CO          GN	Publications

	Drug	Relationship	Evidence
	aripiprazole	PD	Publications
	citalopram	CO PD       GN	Publications, Pathways, Variants
	clozapine	CO PD       GN	Publications
	escitalopram	PD       GN	Publications, Variants
	fluoxetine	CO PD       GN	Publications, Pathways, Variants
	fluvoxamine	PD       GN	Publications
	nicotine	CO          GN	Publications
	olanzapine	CO PD       GN	Publications, Variants
	paroxetine	CO PD       GN	Publications, Pathways, Variants
	risperidone	PD       GN	Publications, Variants
	sertraline	PD       GN	Publications, Pathways

Non-Curated Information

A list of non-curated publications that mention this gene along with other drugs is available.

Curated Information

The following diseases are in curated knowledge about this gene.

	Disease	Relationship	Evidence
	Autism Spectrum Disorder	PD       GN	Publications
	Autistic Disorder	GN	Publications, Variants
	Bulimia	PD	Pathways
	Depression	CO PD       GN	Publications, Pathways, Variants
	Depressive Disorder	PD       GN	Publications
	Depressive Disorder, Major	CO          GN	Publications, Variants
	Obsessive-Compulsive Disorder	PD	Pathways
	Schizophrenia	CO PD       GN	Publications
	Sexual Dysfunctions, Psychological	CO          GN	Publications
	Tobacco Use Disorder	CO          GN	Publications
	Weight gain		Variants

Non-Curated Information

A list of non-curated publications that mention this gene along with other diseases is available.

Additional Datasets

These datasets are minimally curated and are sorted alphabetically by title.

1. A chemogenomic approach to drug discovery: focus on cardiovascular diseases
2. Genetic Variants in Selective Serotonin Reuptake Inhibitors (SSRIs) associated Adverse Events
3. Genetic Variants in Tricyclic Antidepressant associated Adverse Events
4. PMT06_05.xml

Downloads

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LinkOuts

Common Searches

• Comparative Genomics at UCSC
• Search BioCarta and KEGG Pathways at CGAP
• Search Reactome

Non-Curated Publications

A list of non-curated publications that mention this gene is available.