Overview
| Alternate Names: | ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 2; ABCC2; ATP-binding cassette sub-family C (CFTR\/MRP) member 2; Human canalicular multispecific organic anion transporter (cMOAT) mRNA, complete cds.; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; MRP2; MULTISPECIFIC ORGANIC ANION TRANSPORTER, CANALICULAR; CMOAT; OTTHUMP00000020267; canalicular multispecific organic anion transporter |
|---|---|
| Alternate Symbols: | ABC30; CMOAT; DJS; KIAA1010; MRP2; U63970.1; cMRP |
| PharmGKB Accession Id: | PA116 |
Details
| Cytogenetic Location: | chr10 : q24.2 |
|---|---|
| GP mRNA Boundary†: | chr10 : 101532561 - 101601571 |
| GP Gene Boundary†: | chr10 : 101522561 - 101604571 |
| Strand: | plus |
| Product Name: | ATP-binding cassette, sub-family C (CFTR/MRP), member 2, canalicular multispecific organic anion transporter |
†
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped
onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries
by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for
potential regulatory regions.
Curated Annotations (
)
-
rs717620
at chr10:101532568
in
ABCC2,
NANOGP6
Shows decreased function in vitro, and is associated with several complications.- Variant Name:
- ABCC2:(-)24C>T
- Evidence:
-
PMID:17502832
-
rs717620
at chr10:101532568
in
ABCC2,
NANOGP6
Risk or phenotype-associated allele: 5'UTR (-)24C>T, mRNA 118C>T. Phenotype: In patients who received cyclosporine in addition to mycophenylate mofetil (MMF), there was a trend toward an association between the ABCC2 C-24T SNP and mycophenolic acid (MPA) AUC(0-12 h), but without any apparent additive effect: carriers of the CT genotype were associated with higher MPA AUC(0-12 h) compared with TT and CC homozygotes. Study size: 115. Study population/ethnicity: Caucasian cohort from the SOPHIE study cotreated with mycophenylate mofetil (MMF) and cyclosporine. Significance metric(s): p = 0.0087. Type of association: GN; PK- Variant Name:
- ABCC2: 5'UTR (-)24C>T, mRNA 118C>T
- Related Drugs:
- cyclosporine, mycophenolate mofetil, mycophenolic acid
- Related Diseases:
- Organ Transplantation
- Evidence:
-
PMID:19890249
-
rs2273697
at chr10:101553805
in
ABCC2
Common variant, mostly found to have no association, but there was one exception.- Variant Name:
- ABCC2:1249G>A
- Evidence:
-
PMID:17083032
-
rs2273697
at chr10:101553805
in
ABCC2
The A allele of this variant is associated in a gene dose dependent manner with the following phenotypes: 1) increased residual clearance of intravenous talinolol and 2) lower bioavailablilty of orally administered talinolol in healthy German subjects. However, this variant is not associated with alterations in intestinal ABCC2 mRNA or protein levels.- Variant Name:
- ABCC2:c.1249G>A, ABCC2:V417I
- Related Drugs:
- talinolol
- Evidence:
-
PMID:18334920
-
rs2273697
at chr10:101553805
in
ABCC2
Risk or phenotype-associated allele: A. Phenotype: This SNP showed a strong association with the neurological adverse drug reaction caused (ADR) by carbamazepine (P=0.005). The study results indicate that the c.1249A variant is an independent risk factor of carbamazepine CNS ADR. Study size: 146 patients with epilepsy who had been prescribed carbamazepine. Study population: Korean.- Variant Name:
- ABCC2: c.1249G>A; p.V417I
- Related Drugs:
- carbamazepine
- Evidence:
-
PMID:20216337
-
rs17222723
at chr10:101585986
in
ABCC2
Risk or phenotype-associated allele: A. Phenotype: This SNP was part of a haplotype associated with acute cardiotoxicity in response to doxorubicin. Study size: 1697. Study population/ethnicity: Participants of the German non-Hodgkin lymphoma study. Significance metric(s): OR = 2.3; 95% CI, 1.0 to 5.4. Type of association: PD; ADR; TOX.- Variant Name:
- ABCC2 rs8187694, MRP2 Val1188Glu
- Related Drugs:
- doxorubicin
- Related Diseases:
- Arrhythmias, Cardiac, Cardiomyopathies, Drug Toxicity, Lymphoma, Non-Hodgkin
- Evidence:
-
PMID:16330681
-
rs3740066
at chr10:101594197
in
ABCC2
In strong LD with the causative (-)24C>T.- Variant Name:
- ABCC2:3972C>T
- Evidence:
-
PMID:17502832
-
rs8187710
at chr10:101601284
in
ABCC2
Risk or phenotype-associated allele: A. Phenotype: This SNP in ABCC2 was associated with a higher accumulation of lopinavir in peripheral blood mononuclear cells of HIV-treated patients. Study size: 53. Type of association: GN.- Related Drugs:
- lopinavir
- Related Diseases:
- HIV Infections
- Evidence:
-
PMID:19842932
-
rs8187710
at chr10:101601284
in
ABCC2
Risk or phenotype-associated allele: A. Phenotype: This SNP was part of a haplotype associated with acute cardiotoxicity in response to doxorubicin. Study size: 1697. Study population/ethnicity: Participants of the German non-Hodgkin lymphoma study. Significance metric(s): OR = 2.3; 95% CI, 1.0 to 5.4. Type of association: PD; ADR; TOX.- Variant Name:
- ABCC2 rs8187710, MRP2 Cys1515Tyr
- Related Drugs:
- doxorubicin
- Related Diseases:
- Arrhythmias, Cardiac, Cardiomyopathies, Drug Toxicity, Lymphoma, Non-Hodgkin
- Evidence:
-
PMID:16330681
Non-Curated Annotations (
)
-
rs2804402
at chr10:101531573
in
ABCC2,
NANOGP6
ABCC2*2 (−1019a>G) is associated with lower irinotecan clearance and with significant reduction in severe diarrhea in cancer patients.- Variant Name:
- ABCC2: ¿1019a>G
- Related Drugs:
- irinotecan
- Related Diseases:
- Diarrhea, Neoplasms
- Evidence:
-
PMID:19940846
-
rs717620
at chr10:101532568
in
ABCC2,
NANOGP6
The AUCs of irinotecan, SN-38, SN-38 glucuronide, and APC are influenced by rs3740066, rs2306283, rs35605, rs10276036, and rs717620 .- Variant Name:
- ABCC2: ¿24C>T
- Related Drugs:
- irinotecan, SN-38
- Evidence:
-
PMID:19940846
-
rs3740066
at chr10:101594197
in
ABCC2
The AUCs of irinotecan, SN-38, SN-38 glucuronide, and APC are influenced by rs3740066, rs2306283, rs35605, rs10276036, and rs717620 .- Variant Name:
- ABCC2: 3972C>T
- Related Drugs:
- irinotecan, SN-38
- Evidence:
-
PMID:19940846
Variant names are different names that have been used in the literature and other resources to
refer to the same variant.
Non-curated variant information is accumulated solely by computational methods and has not
been verified by the scientific staff at PharmGKB.
Curated Information
The following genes are in curated knowledge about this gene.
| Gene | Relationship | Evidence | |
|---|---|---|---|
|
NR1I2 |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other genes is available.
PharmGKB Curated Pathways
- Codeine and Morphine Pathway (PK)
- Doxorubicin (Cancer PD)
- Doxorubicin (PK)
- Irinotecan Pathway (Cancer)
- Irinotecan Pathway (liver)
- Methotrexate Pathway
- Platinum Aggregation Pathway
- Statin Pathway (Atorvastatin, Lovastatin and Simvastatin PK)
- Statin Pathway (PK)
- Statin Pathway (Pravastatin PK)
- Vinca Alkaloids Pathway (PK)
Curated Information
The following drugs are in curated knowledge about this gene.
| Drug Class | Relationship | Evidence | |
|---|---|---|---|
|
antineoplastic agents |
|
Publications |
|
|
Pyrimidine analogues |
|
Publications |
|
|
xenobiotics |
|
Publications |
Non-Curated Information
A list of non-curated publications that mention this gene along with other drugs is available.
Curated Information
The following diseases are in curated knowledge about this gene.
Non-Curated Information
A list of non-curated publications that mention this gene along with other diseases is available.
Curated Phenotype Datasets
These datasets are sorted alphabetically by title.
- RNA expression in metabolite and transport genes
- FA
Submitted by Howard McLeod, PharmD involving ABCB1, ABCC1, ABCC2, ABCC3, ABCC4, ABCG2, ATM, ATR, BAK1, BAX, BCL2, BCL2L1, CCNA2, CCND1, CDA, CDC2, CDC25C, CDC37, CDC45L, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CES1, CES2, CYP3A4, CYP3A5, DCK, DDB1, DHFR, DPYD, DPYS, DRG1, DTYMK, DUT, E2F1, ECGF1, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, ERCC6, FASLG, FDXR, FPGS, GGH, GSTM1, GSTP1, HMGB1, MAP4, MLH1, MPO, MSH2, MSH6, MTHFR, NFKB1, NME1, NME2, NT5C, PARP1, POLB, POLH, PTGS1, PTGS2, RAD9A, RB1, RRM1, RRM2, SOD1, TDP1, TK1, TOP1, TOP2A, TP53, TUBB, TYMS, UCK2, UGT1A1, UMPS, UNG, UPB1, UPP1, XPA, XPC, XRCC1, and Colonic Neoplasms
Additional Datasets
These datasets are minimally curated and are sorted alphabetically by title.
Downloads
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LinkOuts
- Ref Seq NT Accession:
- AC_000053
- AC_000142
- NC_000010
- NG_011798
- NT_030059
- NW_001838006
- NW_924884
- UniProtKB Accesssion:
- MRP2_HUMAN (Q92887)
- Ensembl ID:
- ENSG00000023839
- GenAtlas ID:
- ABCC2
- GeneCard ID:
- ABCC2
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.